4-Fluoroindole-2-carboxylic acid

Product Name: 4-Fluoroindole-2-carboxylic acid
CAS No.: 399-68-8
Chemical Name: 4-Fluoroindole-2-carboxylic acid
Synonyms: 4-FLUORO-1H-INDOLE-2-CARBOXYLIC ACID;4-FLUOROINDOLE-2-CARBOXYLIC ACID;INDOLE-2-CARBOXYLIC ACID, 4-FLUORO-;4-Fluoro-1H-indol-2-carboxylic acid;1H-Indole-2-carboxylic acid, 4-fluoro-
CBNumber: CB3115215
Molecular Formula: C9H6FNO2
Formula Weight: 179.15
MOL File: 399-68-8.mol

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4-Fluoroindole-2-carboxylic acid Property

Melting point:: 219-220 °C (decomp)
Boiling point:: 422.2±25.0 °C(Predicted)
Density: 1.510±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
form: powder
pka: 4.32±0.30(Predicted)
color: Pale yellow
CAS DataBase Reference: 399-68-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: F592238
Product name: 4-Fluoroindole-2-carboxylicacid
Packaging: 50mg
Price: $55
Updated: 2021/12/16

Matrix Scientific

Product number: 038775
Product name: 4-Fluoro-1H-indole-2-carboxylic acid
Packaging: 500mg
Price: $57
Updated: 2021/12/16

Apolloscientific

Product number: PC4875
Product name: 4-Fluoro-1H-indole-2-carboxylicacid
Packaging: 250mg
Price: $47
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H21-3-20
Product name: 4-Fluoro-1H-indole-2-carboxylic acid
Packaging: 250mg
Price: $52
Updated: 2021/12/16

Matrix Scientific

Product number: 038775
Product name: 4-Fluoro-1H-indole-2-carboxylic acid
Packaging: 1g
Price: $86
Updated: 2021/12/16

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4-Fluoroindole-2-carboxylic acid Chemical Properties,Usage,Production

Synthesis

7593-91-1

399-68-8

General procedure for the synthesis of 4-fluoroindole-2-carboxylic acid from the compound (CAS: 7593-91-1): 4.8 g (31 mmol) of compound 32 was dissolved in 60 mL of 4% NH4OH solution, which was subsequently added to a solution prepared from 52.45 g (188.7 mmol) of ferrous sulfate heptahydrate and 23 mL of concentrated NH4OH in 200 mL of water in a suspension of ferrous hydroxide. The reaction mixture was kept at boiling point for 5 minutes. Upon completion of the reaction, the resulting iron hydroxide precipitate was separated by filtration and washed repeatedly with dilute NH4OH and water. The filtrate was acidified with dilute HCl to a suitable pH and the precipitated solid was subsequently collected by filtration to afford 1.2 g (22% yield) of 4-fluoro-1H-indole-2-carboxylic acid (34) as a white solid. The resulting product could be used directly in the next step of the reaction without further purification.

References

[1] Journal of Medicinal Chemistry, 1988, vol. 31, # 5, p. 944 - 948
[2] Patent: US2014/66453, 2014, A1. Location in patent: Paragraph 0184-0185

4-Fluoroindole-2-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Fluoroindole-2-carboxylic acid Suppliers

China 101 Germany 2 India 2 Italy 1 Russia 1 Switzerland 1 Ukraine 2 United Kingdom 5 United States 13 Global 128

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View Lastest Price from 4-Fluoroindole-2-carboxylic acid manufacturers

Honest Joy Holdings Limited

Product: 2,4-Dihydroxybenzaldehyde oxime 399-68-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.5%
Supply Ability: 100 tons
Release date: 2022-02-20

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-Fluoroindole-2-carboxylic acid 399-68-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Career Henan Chemical Co

Product: 4-Fluoroindole-2-carboxylic acid 399-68-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-24

399-68-8, 4-Fluoroindole-2-carboxylic acidRelated Search:

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INDOLE-2-CARBOXYLIC ACID, 4-FLUORO-

4-FLUORO-1H-INDOLE-2-CARBOXYLIC ACID

4-FLUOROINDOLE-2-CARBOXYLIC ACID

1H-Indole-2-carboxylic acid, 4-fluoro-

4-Fluoro-1H-indol-2-carboxylic acid

399-68-8

C9H6NO2F

pharmacetical

Indole