4-Fluoroindole

Product Name: 4-Fluoroindole
CAS No.: 387-43-9
Chemical Name: 4-Fluoroindole
Synonyms: 4-FLUORO-1H-INDOLE;4-FLUORO-2-METHYLINDOLE;SKL278;4-FLUOROINDOLE;4-Fluoroindole>4-Fluoroindole98%;4-Fluoroindole,96%;4-Fluoroindole ,97%;4-FLUOROINDOLE(4FI);4 - fluorine indole
CBNumber: CB4326199
Molecular Formula: C8H6FN
Formula Weight: 135.14
MOL File: 387-43-9.mol

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4-Fluoroindole Property

Melting point:: 30-32 °C(lit.)
Boiling point:: 90 °C0.4 mm Hg(lit.)
Density: 1.1203 (estimate)
Flash point:: >110°
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: soluble in Methanol
form: Crystalline Powder
pka: 16.40±0.30(Predicted)
color: Yellow to tan
InChI: InChI=1S/C8H6FN/c9-7-2-1-3-8-6(7)4-5-10-8/h1-5,10H
InChIKey: ZWKIJOPJWWZLDI-UHFFFAOYSA-N
SMILES: N1C2=C(C(F)=CC=C2)C=C1
CAS DataBase Reference: 387-43-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 457396
Product name: 4-Fluoroindole
Purity: 97%
Packaging: 1g
Price: $40.7
Updated: 2025/07/31

TCI Chemical

Product number: F0556
Product name: 4-Fluoroindole
Purity: >98.0%(GC)
Packaging: 1g
Price: $54
Updated: 2025/07/31

TRC

Product number: F592263
Product name: 4-Fluoroindole
Packaging: 500mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: J92053
Product name: 4-Fluoroindole
Packaging: 5g
Price: $70
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H31-3-04
Product name: 4-Fluoro-1H-indole
Purity: 98%
Packaging: 5G
Price: $30
Updated: 2021/12/16

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4-Fluoroindole Chemical Properties,Usage,Production

Chemical Properties

Beige low melting solid

Uses

Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators 1 Reactant for preparation of antifungal agents 2 Reactant for preparation of Sodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors for the Management of Hyperglycemia in Diabetes 3 Reactant for preparation of Potent Selective Serotonin Reuptake Inhibitors 4 Reactant for preparation of Inhibitors of HIV-1 attachment 5 Reactant for preparation of monoamine reuptake inhibitors 6 Reactant for preparation of histone deacetylase (HDAC) inhibitors 7 Reactant for preparation of inhibitors of proliferation of human breast cancer cells.

Synthesis

344790-94-9

387-43-9

A suspension was prepared from 1-[2-(2-fluoro-6-nitrophenyl)vinyl]pyrrolidine (6 g, 25.42 mmol) in methanol (50 mL). To this suspension, Raney nickel (500 mg) was added and the hydrogenation reaction was carried out at atmospheric pressure at ambient temperature for 20 hours. After completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and the filtrate was collected. The filtrate was concentrated under vacuum to afford the target product 4-fluoro-1H-indole (2.05 g, 60% yield) as a brown liquid.

References

[1] Patent: WO2009/130481, 2009, A1. Location in patent: Page/Page column 149-150
[2] Patent: JP2016/204312, 2016, A. Location in patent: Paragraph 0026; 0071; 0076; 0079; 0085

4-Fluoroindole Preparation Products And Raw materials

Raw materials

2-Fluoro-6-nitrotoluene Ammonium hydroxide Diethyl oxalate Ferrous sulfate heptahydrate Potassium ethylate

Preparation Products

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4-Fluoroindole Suppliers

Americas 1 Canada 2 China 260 Europe 3 Germany 5 India 13 Italy 1 Japan 3 Slovakia 1 Switzerland 4 Ukraine 1 United Kingdom 21 United States 55 Global 370

Shanghai Harvest Chemical Industrial Co., Ltd.

Tel: 021-31038972,31038973 17321035817
Fax: +86-21-51385350
Email: sales@harvest-chem.com
Country: China
ProdList: 2816
Advantage: 64

Shanghai Junye chemical Co., Ltd

Tel: 021-021-50318666 18516602538
Fax: +86-21-61924293
Email: shlip@163.com
Country: China
ProdList: 58
Advantage: 58

Zhanhua Huibang Chemical Co., Ltd.

Tel: 13906149256
Email: 793211102@qq.com
Country: China
ProdList: 143
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Liaoning Tianhua Chemical Co., Ltd.

Tel: 0418-6530555 2855550
Fax: +86-418-6502885
Country: China
ProdList: 338
Advantage: 69

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

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View Lastest Price from 4-Fluoroindole manufacturers

LAURENT

Product: 4-Fluoroindole 387-43-9
Price: US $9142.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 300kg
Release date: 2025-11-20

LAURENT

Product: 4-Fluoroindole 387-43-9
Price: US $9142.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 300kg
Release date: 2025-11-20

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Fluoroindole 387-43-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20t
Release date: 2024-06-25

387-43-9, 4-Fluoroindole Related Search:

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4-FLUOROINDOLE(4FI)

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4-FLUORO-1H-INDOLE

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SKL278

TIANFU-CHEM - 4-Fluoroindole

4 - fluorine indole

387-43-9

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