6-ETHOXYCARBONYLINDOLE-2-CARBOXYLIC ACID ETHYL ESTER
- Product Name
- 6-ETHOXYCARBONYLINDOLE-2-CARBOXYLIC ACID ETHYL ESTER
- CAS No.
- 107516-75-6
- Chemical Name
- 6-ETHOXYCARBONYLINDOLE-2-CARBOXYLIC ACID ETHYL ESTER
- Synonyms
- Diethyl indole-2,6-dicarboxylate;Diethylindole-2,6-dicarboxylate,96%;Diethyl indole-2,6-dicarboxylate, 96%;1H-Indole-2,6-dicarboxylic acid diethyl ester;diethyl 1H-indole-2,6-dicarboxylate - [D81295];Indole-2,6-dicarboxylic acid diethyl ester, 96%;1H-Indole-2,6-dicarboxylic acid, 2,6-diethyl ester;6-ETHOXYCARBONYLINDOLE-2-CARBOXYLIC ACID ETHYL ESTER
- CBNumber
- CB3116515
- Molecular Formula
- C14H15NO4
- Formula Weight
- 261.27
- MOL File
- Mol file
6-ETHOXYCARBONYLINDOLE-2-CARBOXYLIC ACID ETHYL ESTER Property
- Melting point:
- 119-121℃
- Boiling point:
- 420.2±25.0 °C(Predicted)
- Density
- 1.240±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- pka
- 13.84±0.30(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D679378
- Product name
- Diethyl1H-Indole-2,6-dicarboxylate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 9518AF
- Product name
- Diethylindole-2,6-dicarboxylate
- Packaging
- 250mg
- Price
- $159
- Updated
- 2021/12/16
- Product number
- CHM0299098
- Product name
- 6-ETHOXYCARBONYLINDOLE-2-CARBOXYLIC ACID ETHYL ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.53
- Updated
- 2021/12/16
- Product number
- A261523
- Product name
- Diethyl1H-indole-2,6-dicarboxylate
- Purity
- 97%
- Packaging
- 100mg
- Price
- $25
- Updated
- 2021/12/16
- Product number
- A261523
- Product name
- Diethyl1H-indole-2,6-dicarboxylate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $36
- Updated
- 2021/12/16
6-ETHOXYCARBONYLINDOLE-2-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Uses
6-Ethoxycarbonylindole-2-carboxylic acid ethyl ester is utilized in medicinal chemistry for the design and development of new drugs.
Synthesis
861384-91-0
107516-75-6
Synthesis of diethyl 1H-indole-2,6-dicarboxylate (3): ethyl 4-(3-ethoxy-2,3-dioxopropyl)-3-nitrobenzoate (2) (8.5 g, 27.5 mmol) was suspended in acetic acid (75 mL) and heated to 75°C. After the solid was completely dissolved, water (56 mL) was slowly added, followed by activated zinc powder (17.9 g, 27.5 mmol). 27.5 mmol). The reaction temperature was maintained at 80°C with continuous stirring for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate (50 mL) and filtered through a diatomaceous earth pad. The filtrate was washed sequentially with water (2 x 100 mL), saturated sodium bicarbonate solution (2 x 100 mL) and brine (100 mL). The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to afford the yellow solid product 3 (6.0 g, 83% yield).1H NMR (500 MHz, DMSO-d6) δ 1.33 (m, 6H), 4.34 (m, 4H), 7.21 (s, 1H), 7.65 (d, J = 8.5 Hz, 1H), 7.75 (d, J = 8.5 Hz, 1H), 7.12 (s, 1H), 7.12 (s, 1H), 8.12 (s, 1H). 8.12 (s, 1H), 12.25 (s, 1H). Mass spectrum (MS) m/z (M-H): 259.9.
References
[1] Patent: WO2014/149164, 2014, A1. Location in patent: Paragraph 00802; 00826
[2] Organic and Biomolecular Chemistry, 2015, vol. 13, # 9, p. 2588 - 2599
[3] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 3, p. 938 - 941
[4] Patent: US2006/276453, 2006, A1. Location in patent: Page/Page column 32-33
[5] Patent: WO2011/71716, 2011, A1. Location in patent: Page/Page column 40-41
6-ETHOXYCARBONYLINDOLE-2-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
6-ETHOXYCARBONYLINDOLE-2-CARBOXYLIC ACID ETHYL ESTER Suppliers
- Tel
- 025-86918202 4000255188
- Fax
- 86-025-86918232
- sales@pharmablock.com
- Country
- China
- ProdList
- 5000
- Advantage
- 55
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 400-021-7337 2355568890
- Fax
- 0086-21-50182339
- sales@demochem.com
- Country
- China
- ProdList
- 2572
- Advantage
- 57
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 027- 51832457 94518350
- Fax
- E-Mail Inquiry
- Country
- China
- ProdList
- 746
- Advantage
- 62
- Tel
- 027-86697669 13986148687
- Fax
- 86-027-86697669
- sales@tcaschem.com
- Country
- China
- ProdList
- 3991
- Advantage
- 55
- Tel
- 400-6206333 13167063860
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- 422131432@qq.com
- Country
- China
- ProdList
- 9979
- Advantage
- 55
- Tel
- 025-57018978 18251899859
- Fax
- 025-57018008
- sales@chalf-pharm.com
- Country
- China
- ProdList
- 5674
- Advantage
- 50
- Tel
- 13764913901
- Fax
- -
- info@angtibio.com
- Country
- China
- ProdList
- 4985
- Advantage
- 55