6-Amino-3-methyluracil

Product Name: 6-Amino-3-methyluracil
CAS No.: 21236-97-5
Chemical Name: 6-Amino-3-methyluracil
Synonyms: Urapidil Impurity 73;3-Methyl-6-aMinouracil;6-Amino-3-methyluracil ,97%;6-Amino-3-methyluracil 95+%;6-Amino-3-methylpyrimidine-2,4(1H,3H);6-Amino-3-methyl-1H-pyrimidine-2,4-dione;Urapidil Impurity 15（6-Amino-3-methyluracil）;2,4(1H,3H)-Pyrimidinedione, 6-amino-3-methyl-;6-amino-3-methyldihydropyrimidine-2,4(1H,3H)-dione
CBNumber: CB31176013
Molecular Formula: C5H7N3O2
Formula Weight: 141.13
MOL File: 21236-97-5.mol

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6-Amino-3-methyluracil Property

Melting point:: 350-352°C
Density: 1.339±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly), Water
form: Solid
pka: 8.94±0.40(Predicted)
color: Off-White to Pale Yellow
InChI: InChI=1S/C5H7N3O2/c1-8-4(9)2-3(6)7-5(8)10/h2H,6H2,1H3,(H,7,10)
InChIKey: JGAVPFNFAUWIJY-UHFFFAOYSA-N
SMILES: C1(=O)NC(N)=CC(=O)N1C

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Safety

Risk Statements: 20/21/22
Safety Statements: 24/25-36/37
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: A618275
Product name: 6-Amino-3-methyluracil
Packaging: 250mg
Price: $140
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17538
Product name: 6-Amino-3-methyluracil
Packaging: 1g
Price: $160
Updated: 2021/12/16

AK Scientific

Product number: J53844
Product name: 6-Amino-3-methyluracil
Packaging: 5g
Price: $220
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17538
Product name: 6-Amino-3-methyluracil
Packaging: 250mg
Price: $80
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK452951
Product name: 6-Amino-3-methyluracil
Purity: 97%
Packaging: 1g
Price: $103
Updated: 2021/12/16

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6-Amino-3-methyluracil Chemical Properties,Usage,Production

Chemical Properties

Off-White to Yellow Solid

Synthesis

873-83-6

74-88-4

21236-97-5

4-Amino-2,6-dihydroxypyrimidine (5.18 g, 40.7 mmol) was suspended in hexamethyldisilazane (HMDS, 25 mL) and concentrated sulfuric acid (H2SO4, 0.1 mL) was added. The reaction mixture was heated to reflux for 3 h and subsequently concentrated under vacuum. The residue was dissolved in N,N-dimethylformamide (DMF, 30 mL), iodomethane (MeI, 8.5 mL, 136.5 mmol) was added and stirred continuously for 72 hours at room temperature. Upon completion of the reaction, the mixture was cooled to 0°C and sodium bicarbonate (NaHCO3) was slowly added to neutralize the reaction. Stirring was continued at 0°C until no further gas production was observed. The precipitate was collected by filtration, washed sequentially with methanol (MeOH) and water (H2O), and dried to afford 6-amino-3-methylpyrimidine-2,4(1H,3H)-dione (4.49 g, 78% yield) as a yellow solid, which could be used in the subsequent reaction without further purification. The Rf value of thin layer chromatography (TLC) was 0.23 (Expanding agent: ethyl acetate-methanol-ammonia, 7:2.7:0.3). Nuclear magnetic resonance hydrogen spectrum (1H NMR, 400 MHz, DMSO-d6) δ 10.36 (1H, single peak, NH), 6.16 (2H, single peak, NH2), 4.56 (1H, single peak, H-5), 3.04 (3H, single peak, NCH3). Nuclear magnetic resonance carbon spectrum (13C NMR, 100 MHz, DMSO-d6) δ 163.3 (C-4), 153.5 (C-6), 151.1 (C-2), 74.0 (C-5), 25.9 (NCH3). Melting point (MP): literature value 327°C, measured value 320-323°C.

References

[1] Journal of Agricultural and Food Chemistry, 2016, vol. 64, # 24, p. 5079 - 5084
[2] Patent: WO2017/99612, 2017, A1. Location in patent: Page/Page column 8; 28
[3] Patent: WO2014/143799, 2014, A2. Location in patent: Page/Page column 372
[4] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 5, p. 2001 - 2009

6-Amino-3-methyluracil Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Amino-3-methyluracil Suppliers

Canada 1 China 79 France 1 Germany 1 India 2 The Netherlands 1 United Kingdom 2 United States 16 Global 103

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View Lastest Price from 6-Amino-3-methyluracil manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Titanium dioxide 21236-97-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-07-05

Shaanxi Dideu Medichem Co. Ltd

Product: 6-Amino-3-methyluracil 21236-97-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-14

Career Henan Chemical Co

Product: 6-Amino-3-methyluracil 21236-97-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customzied
Release date: 2019-07-03

21236-97-5, 6-Amino-3-methyluracilRelated Search:

1-(3-AMinopropyl)-4-(2-Methoxyphenyl)piperazine 97% 6-[(3-chloropropyl)amino]-1,3-dimethyluracil 2,4(1H,3H)-Pyrimidinedione, 6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-3-methyl- 2,4(1H,3H)-Pyrimidinedione, 6-[(3-chloropropyl)amino]-3-methyl- Urapidil Impurity 25 6-Amino-1-methyluracil N1-(2-Methoxyphenyl)-1,2-ethanediamine 2,4(1H,3H)-Pyrimidinedione, 6-[(3-hydroxypropyl)amino]-3-methyl- 2,4(1H,3H)-Pyrimidinedione, 6-[[3-[4-(3-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl- N-Nitroso-1-(2-methoxyphenyl)-piperazine aminometradine 1,3,7-TRIMETHYLURIC ACID 6-AMINO-1,3-DIMETHYL-5-NITROSOURACIL 1,3-Dimethyluric acid TETRAMETHYLURIC ACID 1-METHYLURIC ACID 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil 6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

6-Amino-3-methyluracil ,97%

3-Methyl-6-aMinouracil

6-Amino-3-methyl-1H-pyrimidine-2,4-dione

6-Amino-3-methyluracil 95+%

2,4(1H,3H)-Pyrimidinedione, 6-amino-3-methyl-

6-Amino-3-methylpyrimidine-2,4(1H,3H)

6-amino-3-methyldihydropyrimidine-2,4(1H,3H)-dione

Urapidil Impurity 73

Urapidil Impurity 15（6-Amino-3-methyluracil）

21236-97-5

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Nucleotides and Nucleosides

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