6-Amino-3-methyluracil
- Product Name
- 6-Amino-3-methyluracil
- CAS No.
- 21236-97-5
- Chemical Name
- 6-Amino-3-methyluracil
- Synonyms
- Urapidil Impurity 73;3-Methyl-6-aMinouracil;6-Amino-3-methyluracil ,97%;6-Amino-3-methyluracil 95+%;6-Amino-3-methylpyrimidine-2,4(1H,3H);6-Amino-3-methyl-1H-pyrimidine-2,4-dione;Urapidil Impurity 15（6-Amino-3-methyluracil）;2,4(1H,3H)-Pyrimidinedione, 6-amino-3-methyl-;6-amino-3-methyldihydropyrimidine-2,4(1H,3H)-dione
- CBNumber
- CB31176013
- Molecular Formula
- C5H7N3O2
- Formula Weight
- 141.13
- MOL File
- 21236-97-5.mol
6-Amino-3-methyluracil Property
- Melting point:
- 350-352°C
- Density
- 1.339±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly), Water
- form
- Solid
- pka
- 8.94±0.40(Predicted)
- color
- Off-White to Pale Yellow
- InChI
- InChI=1S/C5H7N3O2/c1-8-4(9)2-3(6)7-5(8)10/h2H,6H2,1H3,(H,7,10)
- InChIKey
- JGAVPFNFAUWIJY-UHFFFAOYSA-N
- SMILES
- C1(=O)NC(N)=CC(=O)N1C
Safety
- Risk Statements
- 20/21/22
- Safety Statements
- 24/25-36/37
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A618275
- Product name
- 6-Amino-3-methyluracil
- Packaging
- 250mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- FA17538
- Product name
- 6-Amino-3-methyluracil
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- J53844
- Product name
- 6-Amino-3-methyluracil
- Packaging
- 5g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- FA17538
- Product name
- 6-Amino-3-methyluracil
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- JK452951
- Product name
- 6-Amino-3-methyluracil
- Purity
- 97%
- Packaging
- 1g
- Price
- $103
- Updated
- 2021/12/16
6-Amino-3-methyluracil Chemical Properties,Usage,Production
Chemical Properties
Off-White to Yellow Solid
Synthesis
873-83-6
74-88-4
21236-97-5
4-Amino-2,6-dihydroxypyrimidine (5.18 g, 40.7 mmol) was suspended in hexamethyldisilazane (HMDS, 25 mL) and concentrated sulfuric acid (H2SO4, 0.1 mL) was added. The reaction mixture was heated to reflux for 3 h and subsequently concentrated under vacuum. The residue was dissolved in N,N-dimethylformamide (DMF, 30 mL), iodomethane (MeI, 8.5 mL, 136.5 mmol) was added and stirred continuously for 72 hours at room temperature. Upon completion of the reaction, the mixture was cooled to 0°C and sodium bicarbonate (NaHCO3) was slowly added to neutralize the reaction. Stirring was continued at 0°C until no further gas production was observed. The precipitate was collected by filtration, washed sequentially with methanol (MeOH) and water (H2O), and dried to afford 6-amino-3-methylpyrimidine-2,4(1H,3H)-dione (4.49 g, 78% yield) as a yellow solid, which could be used in the subsequent reaction without further purification. The Rf value of thin layer chromatography (TLC) was 0.23 (Expanding agent: ethyl acetate-methanol-ammonia, 7:2.7:0.3). Nuclear magnetic resonance hydrogen spectrum (1H NMR, 400 MHz, DMSO-d6) δ 10.36 (1H, single peak, NH), 6.16 (2H, single peak, NH2), 4.56 (1H, single peak, H-5), 3.04 (3H, single peak, NCH3). Nuclear magnetic resonance carbon spectrum (13C NMR, 100 MHz, DMSO-d6) δ 163.3 (C-4), 153.5 (C-6), 151.1 (C-2), 74.0 (C-5), 25.9 (NCH3). Melting point (MP): literature value 327°C, measured value 320-323°C.
References
[1] Journal of Agricultural and Food Chemistry, 2016, vol. 64, # 24, p. 5079 - 5084
[2] Patent: WO2017/99612, 2017, A1. Location in patent: Page/Page column 8; 28
[3] Patent: WO2014/143799, 2014, A2. Location in patent: Page/Page column 372
[4] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 5, p. 2001 - 2009
6-Amino-3-methyluracil Preparation Products And Raw materials
Raw materials
Preparation Products
6-Amino-3-methyluracil Suppliers
- Tel
- --
- Fax
- --
- info@specs.net
- Country
- The Netherlands
- ProdList
- 6833
- Advantage
- 70
View Lastest Price from 6-Amino-3-methyluracil manufacturers
- Product
- Titanium dioxide 21236-97-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-07-05
- Product
- 6-Amino-3-methyluracil 21236-97-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-14
- Product
- 6-Amino-3-methyluracil 21236-97-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customzied
- Release date
- 2019-07-03