L-Pyroglutaminol
- Product Name
- L-Pyroglutaminol
- CAS No.
- 17342-08-4
- Chemical Name
- L-Pyroglutaminol
- Synonyms
- PYROGLUTAMINOL;(S)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE;PGLU-OL;ARBA-002;L-Pyr-OL;H-PYR-OL;EOS-61026;H-PGLU-OL;L-PYROGLUTAMINOL;(S)-PyroglutaMinol
- CBNumber
- CB3117668
- Molecular Formula
- C5H9NO2
- Formula Weight
- 115.13
- MOL File
- 17342-08-4.mol
L-Pyroglutaminol Property
- Melting point:
- 79-80 °C(lit.)
- Boiling point:
- 147-149°C 0,06mm
- alpha
- 30 º (C=2, ETOH)
- Density
- 1.1808 (rough estimate)
- refractive index
- 31 ° (C=5, EtOH)
- Flash point:
- 147-149°C/0.06m
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO, Ethanol, Methanol
- form
- Crystals or Crystalline Powder
- pka
- 14.35±0.10(Predicted)
- color
- White to light yellow
- optical activity
- [α]20/D +30°, c = 2 in ethanol
- Water Solubility
- Soluble in water.
- BRN
- 4657914
- CAS DataBase Reference
- 17342-08-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- F
- 3-10
- HS Code
- 29051990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 366366
- Product name
- (S)-5-(Hydroxymethyl)-2-pyrrolidinone
- Purity
- 97%
- Packaging
- 5g
- Price
- $483
- Updated
- 2023/06/20
- Product number
- H0867
- Product name
- (S)-5-(Hydroxymethyl)-2-pyrrolidinone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $30
- Updated
- 2025/07/31
- Product number
- H0867
- Product name
- (S)-5-(Hydroxymethyl)-2-pyrrolidinone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $83
- Updated
- 2025/07/31
- Product number
- P997525
- Product name
- (S)-Pyroglutaminol
- Packaging
- 5g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- CS-B0366
- Product name
- 2-Pyrrolidinone,5-(hydroxymethyl)-,(5S)-
- Purity
- >98.0%
- Packaging
- 100g
- Price
- $136
- Updated
- 2021/12/16
L-Pyroglutaminol Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystals or
Uses
(S)-Pyroglutaminol (cas# 17342-08-4) is a compound useful in organic synthesis.
Synthesis
7149-65-7
17342-08-4
General procedure for the synthesis of (S)-(+)-5-hydroxymethyl-2-pyrrolidinone from ethyl (S)-5-oxopyrrolidine-2-carboxylate: compound III was synthesized as follows: firstly, LiCl (18 mmol) was added to the reaction flask and dissolved in anhydrous tetrahydrofuran (15 ml). The temperature of the reaction system was controlled at -15 to -10°C. Subsequently, potassium borohydride (18 mmol) was added to the system and the reaction was stirred for 30 minutes. In another reaction flask, compound II (9 mmol) was dissolved in anhydrous tetrahydrofuran (20 ml) and cooled to -15 to -10 °C. Then, the previously prepared reaction solution was slowly added dropwise to this system. After the dropwise addition, the reaction was slowly warmed up to room temperature for 2 hours. The reaction process was monitored by TLC to confirm the complete reaction of the raw materials. Next, saturated ammonium chloride solution (5 ml) was added slowly dropwise to the reaction system and stirred for 30 minutes. The reaction mixture was extracted with ethyl acetate, the organic phases were combined and dried with anhydrous sodium sulfate. The dried organic phase was filtered and the filtrate was concentrated under reduced pressure to give compound III (8.55 mmol) in 95% yield.
References
[1] Patent: CN107304179, 2017, A. Location in patent: Paragraph 0033; 0036-0037; 0055; 0058;
[2] Tetrahedron Asymmetry, 2002, vol. 13, # 4, p. 437 - 445
[3] Tetrahedron, 1996, vol. 52, # 10, p. 3719 - 3740
[4] Patent: WO2015/181676, 2015, A1. Location in patent: Page/Page column 170-171
[5] Journal of Organic Chemistry, 1992, vol. 57, # 7, p. 2158 - 2160
L-Pyroglutaminol Preparation Products And Raw materials
Raw materials
Preparation Products
L-Pyroglutaminol Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from L-Pyroglutaminol manufacturers
- Product
- L-Pyr-Ol 17342-08-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-01-17
- Product
- L-Pyroglutaminol 17342-08-4
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2024-11-19
- Product
- L-Pyroglutaminol 17342-08-4
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2024-11-22