ChemicalBook > CAS DataBase List > L-Pyroglutaminol

L-Pyroglutaminol

Product Name
L-Pyroglutaminol
CAS No.
17342-08-4
Chemical Name
L-Pyroglutaminol
Synonyms
PYROGLUTAMINOL;(S)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE;PGLU-OL;ARBA-002;L-Pyr-OL;H-PYR-OL;EOS-61026;H-PGLU-OL;L-PYROGLUTAMINOL;(S)-PyroglutaMinol
CBNumber
CB3117668
Molecular Formula
C5H9NO2
Formula Weight
115.13
MOL File
17342-08-4.mol
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L-Pyroglutaminol Property

Melting point:
79-80 °C(lit.)
Boiling point:
147-149°C 0,06mm
alpha 
30 º (C=2, ETOH)
Density 
1.1808 (rough estimate)
refractive index 
31 ° (C=5, EtOH)
Flash point:
147-149°C/0.06m
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO, Ethanol, Methanol
form 
Crystals or Crystalline Powder
pka
14.35±0.10(Predicted)
color 
White to light yellow
optical activity
[α]20/D +30°, c = 2 in ethanol
Water Solubility 
Soluble in water.
BRN 
4657914
CAS DataBase Reference
17342-08-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
F 
3-10
HS Code 
29051990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
366366
Product name
(S)-5-(Hydroxymethyl)-2-pyrrolidinone
Purity
97%
Packaging
5g
Price
$483
Updated
2023/06/20
TCI Chemical
Product number
H0867
Product name
(S)-5-(Hydroxymethyl)-2-pyrrolidinone
Purity
>98.0%(GC)
Packaging
1g
Price
$30
Updated
2025/07/31
TCI Chemical
Product number
H0867
Product name
(S)-5-(Hydroxymethyl)-2-pyrrolidinone
Purity
>98.0%(GC)
Packaging
5g
Price
$83
Updated
2025/07/31
TRC
Product number
P997525
Product name
(S)-Pyroglutaminol
Packaging
5g
Price
$130
Updated
2021/12/16
ChemScene
Product number
CS-B0366
Product name
2-Pyrrolidinone,5-(hydroxymethyl)-,(5S)-
Purity
>98.0%
Packaging
100g
Price
$136
Updated
2021/12/16
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L-Pyroglutaminol Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystals or

Uses

(S)-Pyroglutaminol (cas# 17342-08-4) is a compound useful in organic synthesis.

Synthesis

7149-65-7

17342-08-4

General procedure for the synthesis of (S)-(+)-5-hydroxymethyl-2-pyrrolidinone from ethyl (S)-5-oxopyrrolidine-2-carboxylate: compound III was synthesized as follows: firstly, LiCl (18 mmol) was added to the reaction flask and dissolved in anhydrous tetrahydrofuran (15 ml). The temperature of the reaction system was controlled at -15 to -10°C. Subsequently, potassium borohydride (18 mmol) was added to the system and the reaction was stirred for 30 minutes. In another reaction flask, compound II (9 mmol) was dissolved in anhydrous tetrahydrofuran (20 ml) and cooled to -15 to -10 °C. Then, the previously prepared reaction solution was slowly added dropwise to this system. After the dropwise addition, the reaction was slowly warmed up to room temperature for 2 hours. The reaction process was monitored by TLC to confirm the complete reaction of the raw materials. Next, saturated ammonium chloride solution (5 ml) was added slowly dropwise to the reaction system and stirred for 30 minutes. The reaction mixture was extracted with ethyl acetate, the organic phases were combined and dried with anhydrous sodium sulfate. The dried organic phase was filtered and the filtrate was concentrated under reduced pressure to give compound III (8.55 mmol) in 95% yield.

References

[1] Patent: CN107304179, 2017, A. Location in patent: Paragraph 0033; 0036-0037; 0055; 0058;
[2] Tetrahedron Asymmetry, 2002, vol. 13, # 4, p. 437 - 445
[3] Tetrahedron, 1996, vol. 52, # 10, p. 3719 - 3740
[4] Patent: WO2015/181676, 2015, A1. Location in patent: Page/Page column 170-171
[5] Journal of Organic Chemistry, 1992, vol. 57, # 7, p. 2158 - 2160

L-Pyroglutaminol Preparation Products And Raw materials

Raw materials

Acetone L-Glutamic acid Sodium borohydride Ethyl acetate Sodium bicarbonate Dichloromethane Acetic acid Methanol Sodium hydroxide Isopropyl alcohol Thionyl chloride

Preparation Products

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View Lastest Price from L-Pyroglutaminol manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
L-Pyr-Ol 17342-08-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-01-17
Hebei Zhuanglai Chemical Trading Co Ltd
Product
L-Pyroglutaminol 17342-08-4
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-19
Hebei Zhuanglai Chemical Trading Co Ltd
Product
L-Pyroglutaminol 17342-08-4
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-22

17342-08-4, L-PyroglutaminolRelated Search:

Polyglutamic acid 2-Pyrrolidinone Dexketoprofen trometamol N-Vinyl-2-pyrrolidone L-Glutamic acid Polyvinylpyrrolidone GLDH Ketorolac tromethamine Fosfomycin tromethamine L-Pyroglutamic acid N-Methyl-2-pyrrolidone N-Methyl-2-pyrrolidone Sodium L-pyroglutamate Hydrogenated Cottonseed Oil METHYL-2-PYRROLIDONE Z-PYR-OH CALCIUM PIDOLATE Cyclopentene oxide

  • (S)-(+)-5-Hydroxymethyl-2-pyrrolidinone,97%
  • (S)-5-Hydroxy-2-pyrrolidine
  • (S)-PyroglutaMinol
  • S)-5-(HydroxyMethyl)-2-pyrrolidinone/L-PyroglutaMinol
  • (S)-(+)-5-HydroxyMethyl-2-pyrrolidinone, 97% 1GR
  • L-pyroglutaMinol,(S)-(+)-5-HydroxyMethyl-2-pyrrolidinone
  • (S)-2-(HydroxyMethyl)pyrrolidin-5-one
  • (S)-5-(HydroxyMethyl)-2-pyrrolidone
  • EOS-61026
  • ARBA-002
  • 2-Pyrrolidinone, 5-(hydroxyMethyl)-, (5S)-
  • (S)-5-(Hydroxymethyl)-2-pyrrolidinone,99%e.e.
  • (S)-(+)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE
  • (S)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE
  • TIMTEC-BB SBB004302
  • PYROGLUTAMINOL
  • PGLU-OL
  • L-Pyr-OL
  • L-PYROGLUTAMINOL
  • (+)-L-PYROGLUTAMOL
  • H-PYR-OL
  • H-PGLU-OL
  • (S)-5-Hydroxymethyl-Pyrrolidin-2-One
  • (S)-(+)-5-HYDROXYMETHYL-2-PYRROLIDINONE 97%
  • (5S)-5-(Hydroxymethyl)pyrrolidin-2-on
  • (S)-5-(Hydroxymethyl)-2-pyrrolidinone&gt
  • 5(S)-5-(Hydroxyl Methyl)Pyrrolidin-2-One Or L-Pyroglutaminol
  • L-Pyroglutaminol USP/EP/BP
  • 17342-08-4 L-Pyroglutaminol
  • (5S)-5-(Hydroxymethyl)-2-pyrrolidinone
  • (<i>S</i>)-5-(Hydroxymethyl)-2-pyrrolidinone
  • 17342-08-4
  • Pyrrolidines
  • Heterocyclic Building Blocks
  • Asymmetric Synthesis
  • ALCOHOL
  • Amides (Chiral)
  • Chiral Building Blocks
  • Heterocycles
  • Miscellaneous Reagents
  • Synthetic Organic Chemistry
  • Amides (Chiral)
  • Chiral Building Blocks
  • pharmacetical
  • Pyrrolidine series
  • Heterocyclic Compounds