Fiacitabine
- Product Name
- Fiacitabine
- CAS No.
- 69123-90-6
- Chemical Name
- Fiacitabine
- Synonyms
- FOAC;FIAC;NSC382097;NSC 382097;NSC -82097;Fiacitabine;NSC-382097;FIAC;FICA, NSC382097, FOAC;Fiacitabine (NSC-382097;NSC 382097; FIAC; FOAC;NSC382097; NSC -82097
- CBNumber
- CB31178749
- Molecular Formula
- C9H11FIN3O4
- Formula Weight
- 371.1
- MOL File
- 69123-90-6.mol
Fiacitabine Property
- Boiling point:
- 524.6±60.0 °C(Predicted)
- Density
- 2.44±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥ 37 mg/mL (99.70 mM)
- pka
- 12.84±0.70(Predicted)
- form
- Powder
N-Bromosuccinimide Price
- Product number
- API0009201
- Product name
- FIACITABINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.97
- Updated
- 2021/12/16
- Product number
- CS-0323
- Product name
- Fiacitabine
- Purity
- 98.93%
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
- Product number
- orb611704
- Product name
- Fiacitabine
- Packaging
- 10mg
- Price
- $615.4
- Updated
- 2021/12/16
- Product number
- API0009201
- Product name
- FIACITABINE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $798
- Updated
- 2021/12/16
- Product number
- CS-0323
- Product name
- Fiacitabine
- Purity
- 98.93%
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
Fiacitabine Chemical Properties,Usage,Production
Description
Fiacitabine is a pyrimidine nucleoside analog with activity against various herpesviruses. It is converted to its triphosphate form in vivo and inhibits viral DNA polymerase. It has been used in trials studying the treatment of HIV Infections and Cytomegalovirus Infections.
Uses
Fiacitabine is an antiviral compound and a selective inhibitior of DNA replication of herpes simplex virus(HSV).
Preparation
The preparation method for Fecitabine involves using 2-deoxy-2-fluoro-tribenzoyl-α-D-arabinofuranose as the raw material. The arabinofuranose is brominated with the hydrobromic acetic acid solution under normal room temperature conditions to obtain 2-deoxy-2-fluoro-tribenzoyl-α-D-brominated arabinofuranose. Next, cytosine is used as the raw material for iodination and is Bz-protected to obtain -(5-Iodo-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide, which serves as the final intermediate. After the reaction, deprotection is carried out to obtain Fecitabine with a total yield as high as 43%.?
Mode of action
Fiacitabine is an antimicrobial agent that inhibits microbial growth by binding to the ribosomal 30S subunit and blocking protein synthesis. It is a prodrug that is converted to 5-fluorocytosine (5FC) in the liver, where it inhibits the activity of the enzyme dihydropyrimidine dehydrogenase, thereby interfering with DNA replication.
Fiacitabine Preparation Products And Raw materials
Raw materials
Preparation Products
Fiacitabine Suppliers
- Tel
- 021-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6011
- Advantage
- 61
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- sales@capotchem.com
- Country
- China
- ProdList
- 18217
- Advantage
- 66
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10194
- Advantage
- 62
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7815
- Advantage
- 57
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9900
- Advantage
- 58
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9901
- Advantage
- 58
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7553
- Advantage
- 61
- Tel
- 0371-85513397
- info@granlen.com
- Country
- China
- ProdList
- 497
- Advantage
- 55
- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
- ProdList
- 4863
- Advantage
- 58
- Tel
- +86-21-5821 5861
- Fax
- +86-21-5106 2861
- sales@letopharm.com
- Country
- China
- ProdList
- 2384
- Advantage
- 58