ChemicalBook > CAS DataBase List > Fiacitabine

Fiacitabine

Product Name: Fiacitabine
CAS No.: 69123-90-6
Chemical Name: Fiacitabine
Synonyms: FOAC;FIAC;NSC382097;NSC 382097;NSC -82097;Fiacitabine;NSC-382097;FIAC;FICA, NSC382097, FOAC;Fiacitabine (NSC-382097;FOAC|||FIAC|||NSC 382097
CBNumber: CB31178749
Molecular Formula: C9H11FIN3O4
Formula Weight: 371.1
MOL File: 69123-90-6.mol

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Fiacitabine Property

Boiling point:: 524.6±60.0 °C(Predicted)
Density: 2.44±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: ≥ 37 mg/mL (99.70 mM)
pka: 12.84±0.70(Predicted)
form: Powder
color: White to off-white
InChI: InChI=1/C9H11FIN3O4/c10-5-6(16)4(2-15)18-8(5)14-1-3(11)7(12)13-9(14)17/h1,4-6,8,15-16H,2H2,(H2,12,13,17)/t4-,5+,6-,8-/s3
InChIKey: GIMSJJHKKXRFGV-BBGMGYHKNA-N
SMILES: [C@H]1(O[C@H](CO)[C@@H](O)[C@@H]1F)N1C=C(C(N)=NC1=O)I |&1:0,2,5,7,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0323
Product name: Fiacitabine
Purity: 98.93%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009201
Product name: FIACITABINE
Purity: 95.00%
Packaging: 5MG
Price: $505.97
Updated: 2021/12/16

ChemScene

Product number: CS-0323
Product name: Fiacitabine
Purity: 98.93%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611704
Product name: Fiacitabine
Packaging: 10mg
Price: $615.4
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009201
Product name: FIACITABINE
Purity: 95.00%
Packaging: 10MG
Price: $798
Updated: 2021/12/16

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Fiacitabine Chemical Properties,Usage,Production

Description

Fiacitabine is a pyrimidine nucleoside analog with activity against various herpesviruses. It is converted to its triphosphate form in vivo and inhibits viral DNA polymerase. It has been used in trials studying the treatment of HIV Infections and Cytomegalovirus Infections.

Uses

Fiacitabine is an antiviral compound and a selective inhibitior of DNA replication of herpes simplex virus(HSV).

Preparation

The preparation method for Fecitabine involves using 2-deoxy-2-fluoro-tribenzoyl-α-D-arabinofuranose as the raw material. The arabinofuranose is brominated with the hydrobromic acetic acid solution under normal room temperature conditions to obtain 2-deoxy-2-fluoro-tribenzoyl-α-D-brominated arabinofuranose. Next, cytosine is used as the raw material for iodination and is Bz-protected to obtain -(5-Iodo-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide, which serves as the final intermediate. After the reaction, deprotection is carried out to obtain Fecitabine with a total yield as high as 43%.?

IC 50

HSV-1; HSV-2

Mode of action

Fiacitabine is an antimicrobial agent that inhibits microbial growth by binding to the ribosomal 30S subunit and blocking protein synthesis. It is a prodrug that is converted to 5-fluorocytosine (5FC) in the liver, where it inhibits the activity of the enzyme dihydropyrimidine dehydrogenase, thereby interfering with DNA replication.

Fiacitabine Preparation Products And Raw materials

Raw materials

Preparation Products

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69123-90-6, FiacitabineRelated Search:

N,N-DIETHYLBENZAMIDE Aspartate aminotransferase 5-IODOCYTOSINE 5-Iodo-2'-deoxycytidine 5-Iodo-2-pyrimidone Fiacitabine

Fiacitabine

2(1H)-Pyrimidinone, 4-amino-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-

4-aMino-1-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodo-

FIAC

FOAC

NSC 382097

NSC382097

4-Amino-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidin-2-one

NSC-382097;FIAC

Fiacitabine (NSC-382097

1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine

5-Iodo-2'-deoxy-2'-fluoro-beta-D-arabinocytidine

NSC 382097; FIAC; FOAC;NSC382097; NSC -82097

NSC -82097

5-Iodo-2’-deoxy-2’-fluoro-beta-D-arabinocytidine, Fiacitabine

5-Iodo-2’-deoxy-2’-fluoro-β-D-arabinocytidine

FICA, NSC382097, FOAC

1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine

Fiacitabine,NSC-382097,NSC382097,Herpes simplex virus,HSV,inhibit,Inhibitor

5-Iodo-2’-deoxy-2’-fluoro-beta-D-arabino cytidine

FOAC|||FIAC|||NSC 382097

Fiacitabine, 10 mM in DMSO

69123-90-6

C9H11FIN3O4