5-Aziridino-2,4-dinitrobenzamide
- Product Name
- 5-Aziridino-2,4-dinitrobenzamide
- CAS No.
- 21919-05-1
- Chemical Name
- 5-Aziridino-2,4-dinitrobenzamide
- Synonyms
- CB-954;CB-1954;tretazicar;NSC 115829;CB 1954;CB-1954;Tretazicar (>Tretazicar (>94%);CB1954(TRETAZICAR);Tretazicar (CB 1954);5-Aziridino-2,4-dinitrobenzamide
- CBNumber
- CB31216241
- Molecular Formula
- C9H8N4O5
- Formula Weight
- 252.18
- MOL File
- 21919-05-1.mol
5-Aziridino-2,4-dinitrobenzamide Property
- Melting point:
- 173 °C
- Boiling point:
- 427.2±45.0 °C(Predicted)
- Density
- 1.671±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Acetonitrile (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- solid
- pka
- 14.23±0.50(Predicted)
- color
- Yellow to Dark Yellow
- InChIKey
- WOCXQMCIOTUMJV-UHFFFAOYSA-N
Safety
- WGK Germany
- 3
- HS Code
- 2933.99.7500
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C2235
- Product name
- CB 1954
- Purity
- solid
- Packaging
- 50mg
- Price
- $169.6
- Updated
- 2024/03/01
- Product number
- C3656
- Product name
- CB 1954
- Packaging
- 10MG
- Price
- $95
- Updated
- 2024/03/01
- Product number
- C3656
- Product name
- CB 1954
- Packaging
- 50MG
- Price
- $286
- Updated
- 2024/03/01
- Product number
- 21023
- Product name
- CB 1954
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21023
- Product name
- CB 1954
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
5-Aziridino-2,4-dinitrobenzamide Chemical Properties,Usage,Production
Description
CB-1954 is a prodrug that is enzymatically activated to generate an antitumor agent that forms DNA-DNA interstrand crosslinks. In rat Walker 256 carcinoma cells, CB-1954 is reduced by NAD(P)H:quinone oxidoreductase (NQO1) to the cytotoxic derivative 5-(aziridin-1-yl)-4-hydroxylamineo 2 nitrobenzamide, a bifunctional alkylating agent.
Uses
5-Aziridino-2,4-dinitrobenzamide is an anticancer prodrug used in gene therapy research and is known to be activated by NAD(P)H Quinone Oxidoreductase 2.
Uses
Tretazicar is an anticancer prodrug used in gene therapy research and is known to be activated by NAD(P)H Quinone Oxidoreductase 2.
Biochem/physiol Actions
CB 1954 is an anticancer prodrug used in gene therapy research; activated by NAD(P)H quinone oxidoreductase?2.
5-Aziridino-2,4-dinitrobenzamide Preparation Products And Raw materials
Raw materials
Preparation Products
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