ChemicalBook > CAS DataBase List > 5-Aziridino-2,4-dinitrobenzamide

5-Aziridino-2,4-dinitrobenzamide

Product Name
5-Aziridino-2,4-dinitrobenzamide
CAS No.
21919-05-1
Chemical Name
5-Aziridino-2,4-dinitrobenzamide
Synonyms
CB-954;CB-1954;tretazicar;NSC 115829;CB 1954;CB-1954;Tretazicar (>Tretazicar (>94%);CB1954(TRETAZICAR);Tretazicar (CB 1954);5-Aziridino-2,4-dinitrobenzamide
CBNumber
CB31216241
Molecular Formula
C9H8N4O5
Formula Weight
252.18
MOL File
21919-05-1.mol
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5-Aziridino-2,4-dinitrobenzamide Property

Melting point:
173 °C
Boiling point:
427.2±45.0 °C(Predicted)
Density 
1.671±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Acetonitrile (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
solid
pka
14.23±0.50(Predicted)
color 
Yellow to Dark Yellow
InChIKey
WOCXQMCIOTUMJV-UHFFFAOYSA-N
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Safety

WGK Germany 
3
HS Code 
2933.99.7500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C2235
Product name
CB 1954
Purity
solid
Packaging
50mg
Price
$169.6
Updated
2024/03/01
TCI Chemical
Product number
C3656
Product name
CB 1954
Packaging
10MG
Price
$95
Updated
2024/03/01
TCI Chemical
Product number
C3656
Product name
CB 1954
Packaging
50MG
Price
$286
Updated
2024/03/01
Cayman Chemical
Product number
21023
Product name
CB 1954
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21023
Product name
CB 1954
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
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5-Aziridino-2,4-dinitrobenzamide Chemical Properties,Usage,Production

Description

CB-1954 is a prodrug that is enzymatically activated to generate an antitumor agent that forms DNA-DNA interstrand crosslinks. In rat Walker 256 carcinoma cells, CB-1954 is reduced by NAD(P)H:quinone oxidoreductase (NQO1) to the cytotoxic derivative 5-(aziridin-1-yl)-4-hydroxylamineo 2 nitrobenzamide, a bifunctional alkylating agent.

Uses

5-Aziridino-2,4-dinitrobenzamide is an anticancer prodrug used in gene therapy research and is known to be activated by NAD(P)H Quinone Oxidoreductase 2.

Uses

Tretazicar is an anticancer prodrug used in gene therapy research and is known to be activated by NAD(P)H Quinone Oxidoreductase 2.

Biochem/physiol Actions

CB 1954 is an anticancer prodrug used in gene therapy research; activated by NAD(P)H quinone oxidoreductase?2.

5-Aziridino-2,4-dinitrobenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Aziridino-2,4-dinitrobenzamide Suppliers

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21919-05-1, 5-Aziridino-2,4-dinitrobenzamideRelated Search:

Silicon tetrahydride Azetidine N-PROPYLBENZENE Chlorantraniliprole Benzamide 4-Amino-3-nitro-6-methylaniline 2,4-Dinitrobenzaldehyde 2-AMINO-4-NITROBENZAMIDE 1-phenylaziridine 2,4,5-Triaminotoluene 5-Aziridino-2,4-dinitrobenzamide

  • CB 1954;CB-1954
  • 5-(1-aziridinyl)-2,4-dinitrobenzamide
  • NSC 115829
  • tretazicar
  • 5-(1-Aziridinyl)-2,4-dinitrobenzamide, 5-(Aziridin-1-yl)-2,4-dinitrobenzamide
  • 5-Aziridino-2,4-dinitrobenzamide
  • 2,4-Dinitro-5-(aziridine-1-yl)benzamide
  • CB-954
  • CB-1954
  • 5-(Aziridin-1-yl)-2,4-dinitrobenzamide
  • CB1954(TRETAZICAR)
  • Tretazicar (&gt
  • Benzamide, 5-(1-aziridinyl)-2,4-dinitro-
  • 2,4-Dinitro-5-ethyleneiminobenzamide
  • Tretazicar (>94%)
  • Tretazicar (CB 1954)
  • Tretazicar,NQO1,DNA Alkylator/Crosslinker,rat,bifunctional,Inhibitor,inhibit,agent,cross-link,256,line,4-hydroxylamine,Walker,CB 1954,DNA,CB-1954,tumour
  • 21919-05-1