ChemicalBook > CAS DataBase List > Tenidap

Tenidap

Product Name
Tenidap
CAS No.
120210-48-2
Chemical Name
Tenidap
Synonyms
TENIDAP;AKOS 91367;TENIDAP USP/EP/BP;CP66248,CP-66248-2;5-Chloro-2，3-dihydro-2-oxo-3-(2-thenoyl)-1H-indole-1-carboxamide;(Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylMethylene)-2-oxo-1H- indole-1-carboxaMide;(3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylMethylene)-2-oxo-1H-indole-1-carboxaMide;1H-Indole-1-carboxamide, 5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-, (3Z)-
CBNumber
CB3121977
Molecular Formula
C14H9ClN2O3S
Formula Weight
320.75
MOL File
120210-48-2.mol
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Tenidap Property

Melting point:
230° (dec)
Boiling point:
538.1±60.0 °C(Predicted)
Density 
1.648±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
DMSO: soluble1mg/mL, clear (warmed)
form 
powder
pka
4.50±1.00(Predicted)
color 
faint yellow to dark yellow
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0196
Product name
Tenidap
Purity
≥97% (HPLC)
Packaging
5mg
Price
$129
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0196
Product name
Tenidap
Purity
≥97% (HPLC)
Packaging
25mg
Price
$401
Updated
2024/03/01
Cayman Chemical
Product number
17413
Product name
Tenidap
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17413
Product name
Tenidap
Purity
≥98%
Packaging
5mg
Price
$70
Updated
2024/03/01
Cayman Chemical
Product number
17413
Product name
Tenidap
Purity
≥98%
Packaging
10mg
Price
$122
Updated
2024/03/01
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Tenidap Chemical Properties,Usage,Production

Uses

Anti-inflammatory (osteoarthritis and rheumatoid arthritis).

Uses

Tenidap is one of the nonsteroidal antiinflammatory drugs (NSAIDs). Tenidap is an NSAID that preferentially inhibits COX-1. Tenidap inhibits formation of pro-inflammatory arachidonic acid metabolites in isolated human peripheral polymorphonuclear leukocytes.

Definition

ChEBI: Tenidap is a member of indoles, a member of ureas, a member of thiophenes and an organochlorine compound. It has a role as a non-steroidal anti-inflammatory drug and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor.

Biological Activity

NSAID that preferentially inhibits COX-1 (IC 50 values are < 0.03, 1.2 and > 30 μ M for COX-1, COX-2 and 5-lipoxygenase respectively). Inhibits formation of pro-inflammatory arachidonic acid metabolites in isolated human peripheral polymorphonuclear leukocytes. Opener of inward rectifying hK IR 2.3 channel (EC 50 = 402 nM).

storage

Store at +4°C

Mode of action

Tenidap is an anti-inflammatory agent developed by Pfizer with a unique structure that is different and distinguishable from NSAIDs. The mechanism of action of tenidap is that it has dual inhibitory effects on lipoxygenase and dioxygenase, and has antagonism on interleukin-1 (IL-1).

Tenidap Preparation Products And Raw materials

Raw materials

Formyl chloride Chloral hydrate 4-Methylmorpholine Ethanol Methyl chloroformate Sodium bicarbonate Hydroxylamine hydrochloride 4-Chloroaniline

Preparation Products

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Tenidap Suppliers

China 48 Europe 3 Germany 2 India 1 United Kingdom 4 United States 13 Global 71
J & K SCIENTIFIC LTD.
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View Lastest Price from Tenidap manufacturers

Dideu Industries Group Limited
Product
TENIDAP 120210-48-2
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-06

120210-48-2, TenidapRelated Search:

Delgocitinib Coenzyme Q10 Metadoxine Feprazone Ibrutinib Diclofenac sodium

  • TENIDAP
  • AKOS 91367
  • 5-Chloro-2，3-dihydro-2-oxo-3-(2-thenoyl)-1H-indole-1-carboxamide
  • CP66248,CP-66248-2
  • (3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylMethylene)-2-oxo-1H-indole-1-carboxaMide
  • (Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylMethylene)-2-oxo-1H- indole-1-carboxaMide
  • 1H-Indole-1-carboxamide, 5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-, (3Z)-
  • TENIDAP USP/EP/BP
  • 120210-48-2
  • C14H9N2O3SCl