ChemicalBook > CAS DataBase List > Tenidap

Tenidap

Product Name: Tenidap
CAS No.: 120210-48-2
Chemical Name: Tenidap
Synonyms: TENIDAP;AKOS 91367;TENIDAP USP/EP/BP;CP66248,CP-66248-2;5-Chloro-2，3-dihydro-2-oxo-3-(2-thenoyl)-1H-indole-1-carboxamide;(Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylMethylene)-2-oxo-1H- indole-1-carboxaMide;(3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylMethylene)-2-oxo-1H-indole-1-carboxaMide;(3Z)-5-CHLORO-3-[HYDROXY(2-THIENYL)METHYLENE]-2-OXO-2,3-DIHYDRO-1H-INDOLE-1-CARBOXAMIDE;1H-Indole-1-carboxamide, 5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-, (3Z)-
CBNumber: CB3121977
Molecular Formula: C14H9ClN2O3S
Formula Weight: 320.75
MOL File: 120210-48-2.mol

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Tenidap Property

Melting point:: 230° (dec)
Boiling point:: 538.1±60.0 °C(Predicted)
Density: 1.648±0.06 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: DMSO: soluble1mg/mL, clear (warmed)
form: powder
pka: 4.50±1.00(Predicted)
color: faint yellow to dark yellow

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0196
Product name: Tenidap
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $129
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0196
Product name: Tenidap
Purity: ≥97% (HPLC)
Packaging: 25mg
Price: $401
Updated: 2024/03/01

Cayman Chemical

Product number: 17413
Product name: Tenidap
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17413
Product name: Tenidap
Purity: ≥98%
Packaging: 5mg
Price: $70
Updated: 2024/03/01

Cayman Chemical

Product number: 17413
Product name: Tenidap
Purity: ≥98%
Packaging: 10mg
Price: $122
Updated: 2024/03/01

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Tenidap Chemical Properties,Usage,Production

Chemical Properties

Fluffy and yellow crystals from acetic acid, melting point 230°C (decomposition). Tenidap Sodium (Tenidap Sodium): C14H8C1N2NaO3S.[119784-94-0]. Crystallized from methanol-isopropanol, melting point 237-238°C.

Uses

Anti-inflammatory (osteoarthritis and rheumatoid arthritis).

Uses

Tenidap is one of the nonsteroidal antiinflammatory drugs (NSAIDs). Tenidap is an NSAID that preferentially inhibits COX-1. Tenidap inhibits formation of pro-inflammatory arachidonic acid metabolites in isolated human peripheral polymorphonuclear leukocytes.

Definition

ChEBI: Tenidap is a member of indoles, a member of ureas, a member of thiophenes and an organochlorine compound. It has a role as a non-steroidal anti-inflammatory drug and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor.

Biological Activity

NSAID that preferentially inhibits COX-1 (IC 50 values are < 0.03, 1.2 and > 30 μ M for COX-1, COX-2 and 5-lipoxygenase respectively). Inhibits formation of pro-inflammatory arachidonic acid metabolites in isolated human peripheral polymorphonuclear leukocytes. Opener of inward rectifying hK IR 2.3 channel (EC 50 = 402 nM).

storage

Store at +4°C

Mode of action

Tenidap is an anti-inflammatory agent developed by Pfizer with a unique structure that is different and distinguishable from NSAIDs. The mechanism of action of tenidap is that it has dual inhibitory effects on lipoxygenase and dioxygenase, and has antagonism on interleukin-1 (IL-1).

Tenidap Preparation Products And Raw materials

Raw materials

Formyl chloride Chloral hydrate 4-Methylmorpholine Ethanol Methyl chloroformate Sodium bicarbonate Hydroxylamine hydrochloride 4-Chloroaniline

Preparation Products

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Tenidap Suppliers

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View Lastest Price from Tenidap manufacturers

Sinoway Industrial co., ltd.

Product: TENIDAP 120210-48-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99% up by hplc
Supply Ability: 20tons
Release date: 2025-05-08

Dideu Industries Group Limited

Product: TENIDAP 120210-48-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-06

120210-48-2, TenidapRelated Search:

Delgocitinib Coenzyme Q10 Metadoxine Feprazone Ibrutinib Diclofenac sodium

TENIDAP

AKOS 91367

5-Chloro-2，3-dihydro-2-oxo-3-(2-thenoyl)-1H-indole-1-carboxamide

CP66248,CP-66248-2

(3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylMethylene)-2-oxo-1H-indole-1-carboxaMide

(Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylMethylene)-2-oxo-1H- indole-1-carboxaMide

1H-Indole-1-carboxamide, 5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-, (3Z)-

TENIDAP USP/EP/BP

(3Z)-5-CHLORO-3-[HYDROXY(2-THIENYL)METHYLENE]-2-OXO-2,3-DIHYDRO-1H-INDOLE-1-CARBOXAMIDE

120210-48-2

C14H9N2O3SCl