Ibandronate sodium

Product Name: Ibandronate sodium
CAS No.: 138844-81-2
Chemical Name: Ibandronate sodium
Synonyms: Bondronat;Ibandronate sodium;IBANDRONATE USP/EP/BP;Sodium Ibandronate >IbandronicAcidSodiumSal;Ibandronic Acid Sodium Salt;Ibandronate sodiuM Bondronat;Ibandronate Sodium Anhydrous;Ibandronate sodium USP/EP/BP;(1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonic acid monosodium salt
CBNumber: CB31261504
Molecular Formula: C9H24NNaO7P2
Formula Weight: 343.23
MOL File: 138844-81-2.mol

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Ibandronate sodium Property

storage temp.: 2-8°C
solubility: H2O: >10mg/mL
form: solid
color: white
Merck: 14,4873
Stability:: Hygroscopic
InChIKey: LXLBEOAZMZAZND-UHFFFAOYSA-M

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Safety

WGK Germany: 3
RTECS: SZ8563300
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I5784
Product name: Ibandronate sodium salt
Purity: ≥97% (NMR), solid
Packaging: 10mg
Price: $47.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: I5784
Product name: Ibandronate sodium salt
Purity: ≥97% (NMR), solid
Packaging: 50mg
Price: $461
Updated: 2024/03/01

TCI Chemical

Product number: S0877
Product name: Sodium Ibandronate
Purity: >90.0%(T)
Packaging: 1g
Price: $244
Updated: 2024/03/01

TCI Chemical

Product number: S0877
Product name: Sodium Ibandronate
Purity: >90.0%(T)
Packaging: 5g
Price: $614
Updated: 2024/03/01

TRC

Product number: I120005
Product name: Ibandronate sodium salt
Packaging: 50mg
Price: $55
Updated: 2021/12/16

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Ibandronate sodium Chemical Properties,Usage,Production

Description

ibandronate sodium (BONIVA) is a nitrogen-containing bisphosphonate that inhibits osteoclast-mediated bone resorption. The chemical name for ibandronate sodium is 3-(N-methyl-N-pentyl) amino-1-hydroxypropane-1,1-diphosphonic acid, monosodium salt, monohydrate with the molecular formula C9H22NO7P2Na?H20 and a molecular weight of 359.24. Ibandronate sodium is a white-to off-white powder. It is freely soluble in water and practically insoluble in organic solvents.
BONIVA is available as a white, oblong, 2.5-mg film-coated tablet for daily oral administration or as a white, oblong, 150-mg film-coated tablet for once-monthly oral administration. One 2.5-mg film-coated tablet contains 2.813 mg ibandronate monosodium monohydrate, equivalent to 2.5 mg free acid. One 150-mg film-coated tablet contains 168.75 mg ibandronate monosodium monohydrate, equivalent to 150 mg free acid. BONIVA also contains the following inactive ingredients: lactose monohydrate, povidone, microcrystalline cellulose, crospovidone, purified stearic acid, colloidal silicon dioxide, and purified water. The tablet film coating contains hypromellose, titanium dioxide, talc, polyethylene glycol 6000, and purified water.

Uses

Ibandronate sodium salt has been used to study its effect on the proliferation and ultrastructure of Leishmania and Giardia by the generation of concentration curves. It has also been used to elucidate the route by which nitrogen-containing bisphosphonates (N-BPs) enter the cytosol and inhibit their molecular target.

Biochem/physiol Actions

Ibandronate sodium inhibits farnesyl diphosphate synthase (IC50 = 20 nM). Ibandronate sodium is also a bone resorption inhibitor. It has been investigated for in vitro anti-tumor effects, such as apoptosis induction, inhibitor of cell growth, inhibition of invasive behavior, and inhibition of angiogenesis and for its in vivo role in various cancers including breast and prostate cancers.

Pharmacokinetics

Its mechanism of action is identical to the other bisphosphonate agents. Administered daily (2.5 mg), ibandronate has been clinically shown to reduce the risk of vertebral fractures by 62%. If administered on an intermittent basis (20 mg), it reduces the risk of vertebral fractures by 50%. Ibandronate (2.5 mg daily), along with 500 mg of supplemental calcium, has been clinically shown to increase BMD in the hip (1.8%), femoral neck (2.0%), and lumbar spine (3.1%). The 150-mg formulation approved in March 2005 represents the first oral therapy for a chronic disease to be administered once monthly.

Clinical Use

Ibandronate sodium was approved in May 2003 for the treatment and prevention of osteoporosis in postmenopausal women.

Side effects

Adverse events as sociated with the injectable form ulation included arthralgia, back and abdominal pain, and hypertens ion. There is a risk of renal toxicity that is inversely related to the rate of administration of this formulation.

Metabolism

The oral bioavailability of this agent is extremely poor (0.6%) and is adversely affected by the presence of food, beverages other than water, and other medications, including calcium or vitamin D supplements and antacids. Because of the increased calcium content in mineral water, patients should not take this medication with this type of water. Drugs that inhibit gastric acid secretion (e.g., H2 antagonists and proton-pump inhibitors) actually promote ibandronate absorption. Like the others in this therapeutic class, ibandronate is not metabolized, and that which is not bound to the bone (40–50% of the absorbed dose) is eliminated renally unchanged. It does not inhibit the cytochrome P450 (CYP450) isozymes. This agent does not require any dosage adjustment for patients with hepatic impairment or mild to moderate renal impairment (creatinine clearance, >30 mL/min). Ibandronate should not be prescribed for patients with severe renal impairment (creatinine clearance, <30 mL/min).

Ibandronate sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ibandronate sodium manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Ibandronate 138844-81-2
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-05-14

Guangzhou PI PI BIOTECH INC

Product: Ibandronate Sodium 138844-81-2
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 90%+
Supply Ability: 10g
Release date: 2021-09-16

Dideu Industries Group Limited

Product: IBANDRONATE
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-28

138844-81-2, Ibandronate sodiumRelated Search:

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sodium [1-hydroxy-1-(hydroxy-oxido-phosphoryl)-3-(methyl-pentyl-amino) propyl]phosphonic acid

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(1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonic acid monosodium salt

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Ibandronate sodiumQ: What is Ibandronate sodium Q: What is the CAS Number of Ibandronate sodium Q: What is the storage condition of Ibandronate sodium Q: What are the applications of Ibandronate sodium

138844-81-2

C9H22NNaO7P2

anti-osteoporosis

API