ChemicalBook > CAS DataBase List > 1-Phenylcyclobutanecarboxylic acid

1-Phenylcyclobutanecarboxylic acid

Product Name: 1-Phenylcyclobutanecarboxylic acid
CAS No.: 37828-19-6
Chemical Name: 1-Phenylcyclobutanecarboxylic acid
Synonyms: 1-Phenylcyclobutanecarboxylic acid;Phenylcyclobutane-1-carboxylic acid;Cyclobutanecarboxylic acid, 1-phenyl-;2-phenyl-1-cyclobutanecarboxylic acid
CBNumber: CB31263487
Molecular Formula: C11H12O2
Formula Weight: 176.21
MOL File: 37828-19-6.mol

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1-Phenylcyclobutanecarboxylic acid Property

Melting point:: 100-102℃
Boiling point:: 323.9±21.0 °C(Predicted)
Density: 1.208±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder
pka: 4.39±0.20(Predicted)
color: White

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Safety

HS Code: 2916200090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: P336618
Product name: 1-PhenylcyclobutanecarboxylicAcid
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: J55188
Product name: 1-Phenylcyclobutanecarboxylicacid
Packaging: 1g
Price: $85
Updated: 2021/12/16

Apolloscientific

Product number: OR2270
Product name: 1-Phenylcyclobutane-1-carboxylicacid
Packaging: 1g
Price: $92
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2721-1-W3
Product name: Phenylcyclobutane-1-carboxylic acid
Packaging: 1g
Price: $101
Updated: 2021/12/16

Matrix Scientific

Product number: 082053
Product name: 1-Phenylcyclobutanecarboxylic acid
Purity: 97%
Packaging: 1g
Price: $230
Updated: 2021/12/16

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1-Phenylcyclobutanecarboxylic acid Chemical Properties,Usage,Production

Synthesis

14377-68-5

37828-19-6

Part A. 1-Phenyl-1-cyclobutanecarbonitrile (5.0 g, 31.83 mmol) and potassium hydroxide (85%, 6.29 g, 95.49 mmol, 3 eq.) were dissolved in ethylene glycol (10 mL) and the reaction was heated for 6 h at 185-190 °C under nitrogen protection. The completion of the reaction was monitored by LC-MS. The reaction mixture was cooled and diluted with the addition of water. The mixture was extracted with ether (3 x 10 mL). The aqueous layer was acidified with concentrated hydrochloric acid to pH < 2 and subsequently extracted with chloroform (2 x 10 mL). The chloroform layers were combined, washed sequentially with water and saturated saline, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 1-phenyl-1-cyclobutanecarboxylic acid (4.43 g, yield 79.2%). lC-MS (ESI+) m/z: 177.4 [M+H]+, retention time tR = 2.56 min (mobile phase: 10-90% acetonitrile/water, run time 6 min) .

References

[1] Chemische Berichte, 1984, vol. 117, # 11, p. 3303 - 3319
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 18, p. 7341 - 7348
[3] Patent: WO2003/99276, 2003, A1. Location in patent: Page 316-317
[4] Journal of Organometallic Chemistry, 1993, vol. 448, # 1-2, p. 9 - 14
[5] Pharmaceutical Chemistry Journal, 1980, vol. 14, # 2, p. 114 - 118

1-Phenylcyclobutanecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-Phenylcyclobutanecarboxylic acid manufacturers

Career Henan Chemical Co

Product: 1-Phenylcyclobutanecarboxylic acid 37828-19-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-25

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