1-Phenylcyclobutanecarboxylic acid
- Product Name
- 1-Phenylcyclobutanecarboxylic acid
- CAS No.
- 37828-19-6
- Chemical Name
- 1-Phenylcyclobutanecarboxylic acid
- Synonyms
- 1-Phenylcyclobutanecarboxylic acid;Phenylcyclobutane-1-carboxylic acid;Cyclobutanecarboxylic acid, 1-phenyl-;2-phenyl-1-cyclobutanecarboxylic acid
- CBNumber
- CB31263487
- Molecular Formula
- C11H12O2
- Formula Weight
- 176.21
- MOL File
- 37828-19-6.mol
1-Phenylcyclobutanecarboxylic acid Property
- Melting point:
- 100-102℃
- Boiling point:
- 323.9±21.0 °C(Predicted)
- Density
- 1.208±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder
- pka
- 4.39±0.20(Predicted)
- color
- White
Safety
- HS Code
- 2916200090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- P336618
- Product name
- 1-PhenylcyclobutanecarboxylicAcid
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- J55188
- Product name
- 1-Phenylcyclobutanecarboxylicacid
- Packaging
- 1g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- OR2270
- Product name
- 1-Phenylcyclobutane-1-carboxylicacid
- Packaging
- 1g
- Price
- $92
- Updated
- 2021/12/16
- Product number
- 2721-1-W3
- Product name
- Phenylcyclobutane-1-carboxylic acid
- Packaging
- 1g
- Price
- $101
- Updated
- 2021/12/16
- Product number
- 082053
- Product name
- 1-Phenylcyclobutanecarboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $230
- Updated
- 2021/12/16
1-Phenylcyclobutanecarboxylic acid Chemical Properties,Usage,Production
Synthesis
14377-68-5
37828-19-6
Part A. 1-Phenyl-1-cyclobutanecarbonitrile (5.0 g, 31.83 mmol) and potassium hydroxide (85%, 6.29 g, 95.49 mmol, 3 eq.) were dissolved in ethylene glycol (10 mL) and the reaction was heated for 6 h at 185-190 °C under nitrogen protection. The completion of the reaction was monitored by LC-MS. The reaction mixture was cooled and diluted with the addition of water. The mixture was extracted with ether (3 x 10 mL). The aqueous layer was acidified with concentrated hydrochloric acid to pH < 2 and subsequently extracted with chloroform (2 x 10 mL). The chloroform layers were combined, washed sequentially with water and saturated saline, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 1-phenyl-1-cyclobutanecarboxylic acid (4.43 g, yield 79.2%). lC-MS (ESI+) m/z: 177.4 [M+H]+, retention time tR = 2.56 min (mobile phase: 10-90% acetonitrile/water, run time 6 min) .
References
[1] Chemische Berichte, 1984, vol. 117, # 11, p. 3303 - 3319
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 18, p. 7341 - 7348
[3] Patent: WO2003/99276, 2003, A1. Location in patent: Page 316-317
[4] Journal of Organometallic Chemistry, 1993, vol. 448, # 1-2, p. 9 - 14
[5] Pharmaceutical Chemistry Journal, 1980, vol. 14, # 2, p. 114 - 118
1-Phenylcyclobutanecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1-Phenylcyclobutanecarboxylic acid Suppliers
- Tel
- --
- Fax
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- sales@ajchem.in
- Country
- India
- ProdList
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- Advantage
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View Lastest Price from 1-Phenylcyclobutanecarboxylic acid manufacturers
- Product
- 1-Phenylcyclobutanecarboxylic acid 37828-19-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-25