Adenanthin

ChemicalBook > CAS DataBase List > Adenanthin

Product Name: Adenanthin
CAS No.: 111917-59-0
Chemical Name: Adenanthin
Synonyms: Adenanthin;Actinodephnine Acuminatin Acuminatoside Adenanthin;Kaur-16-ene-6,15-dione, 1,7,11-tris(acetyloxy)-3-hydroxy-, (1α,3β,7β,11β)-;Kaur-16-ene-6,15-dione,1,7,11-tris(acetyloxy)-3-hydroxy-, (1a,3b,7b,11b)- (9CI)
CBNumber: CB31267733
Molecular Formula: C26H34O9
Formula Weight: 490.55
MOL File: 111917-59-0.mol

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Adenanthin Property

Boiling point:: 593.4±50.0 °C(Predicted)
Density: 1.29±0.1 g/cm3(Predicted)
pka: 14.13±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Arctom

Product number: CFN99215
Product name: Adenanthin
Packaging: 5mg
Price: $498
Updated: 2021/12/16

Crysdot

Product number: CD32002839
Product name: Adenanthin
Purity: 97%
Packaging: 5mg
Price: $930
Updated: 2021/12/16

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Adenanthin Chemical Properties,Usage,Production

Enzyme inhibitor

This diterpenoid (FW = 484.63 g/mol; CAS 111917-59-0) from the leaves of Rabdosia adenantha, induces differentiation of acute promyelocytic leukemia (APL) cells. Adenanthin targets the conserved cysteine thiols of peroxiredoxins I and II (or Prx I and Prx II), inhibiting their peroxidase activities and consequently increasing cellular hydrogen peroxide. The latter leads to the activation of Extracellular signal-Regulated Kinases (ERKs) and increased transcription of CCAAT/enhancer-binding protein β (or C/EBPs), further contributing to differentiation. Adenanthin induces APL-like cell differentiation, represses tumor growth in vivo and prolongs the survival of mouse APL models that are sensitive and resistant to retinoic acid.

Adenanthin Preparation Products And Raw materials

Raw materials

Preparation Products

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Adenanthin

Actinodephnine Acuminatin Acuminatoside Adenanthin

Kaur-16-ene-6,15-dione,1,7,11-tris(acetyloxy)-3-hydroxy-, (1a,3b,7b,11b)- (9CI)

Kaur-16-ene-6,15-dione, 1,7,11-tris(acetyloxy)-3-hydroxy-, (1α,3β,7β,11β)-

111917-59-0