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Adenanthin

Product Name
Adenanthin
CAS No.
111917-59-0
Chemical Name
Adenanthin
Synonyms
Adenanthin;Actinodephnine Acuminatin Acuminatoside Adenanthin;Kaur-16-ene-6,15-dione, 1,7,11-tris(acetyloxy)-3-hydroxy-, (1α,3β,7β,11β)-;Kaur-16-ene-6,15-dione,1,7,11-tris(acetyloxy)-3-hydroxy-, (1a,3b,7b,11b)- (9CI)
CBNumber
CB31267733
Molecular Formula
C26H34O9
Formula Weight
490.55
MOL File
111917-59-0.mol
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Adenanthin Property

Boiling point:
593.4±50.0 °C(Predicted)
Density 
1.29±0.1 g/cm3(Predicted)
pka
14.13±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Arctom
Product number
CFN99215
Product name
Adenanthin
Packaging
5mg
Price
$498
Updated
2021/12/16
Crysdot
Product number
CD32002839
Product name
Adenanthin
Purity
97%
Packaging
5mg
Price
$930
Updated
2021/12/16
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Adenanthin Chemical Properties,Usage,Production

Enzyme inhibitor

This diterpenoid (FW = 484.63 g/mol; CAS 111917-59-0) from the leaves of Rabdosia adenantha, induces differentiation of acute promyelocytic leukemia (APL) cells. Adenanthin targets the conserved cysteine thiols of peroxiredoxins I and II (or Prx I and Prx II), inhibiting their peroxidase activities and consequently increasing cellular hydrogen peroxide. The latter leads to the activation of Extracellular signal-Regulated Kinases (ERKs) and increased transcription of CCAAT/enhancer-binding protein β (or C/EBPs), further contributing to differentiation. Adenanthin induces APL-like cell differentiation, represses tumor growth in vivo and prolongs the survival of mouse APL models that are sensitive and resistant to retinoic acid.

Adenanthin Preparation Products And Raw materials

Raw materials

Preparation Products

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  • Adenanthin
  • Actinodephnine Acuminatin Acuminatoside Adenanthin
  • Kaur-16-ene-6,15-dione,1,7,11-tris(acetyloxy)-3-hydroxy-, (1a,3b,7b,11b)- (9CI)
  • Kaur-16-ene-6,15-dione, 1,7,11-tris(acetyloxy)-3-hydroxy-, (1α,3β,7β,11β)-
  • 111917-59-0