2-Cyano-3-chloropyridine
- Product Name
- 2-Cyano-3-chloropyridine
- CAS No.
- 38180-46-0
- Chemical Name
- 2-Cyano-3-chloropyridine
- Synonyms
- 3-Chloropicolinonitrile;oro-2-cyanopyridine;2-Cyano-3-chloropyri;3-CHLORO-2-CYANOPYRIDINE;2-CYANO-3-CHLOROPYRIDINE;3-Chloro-2-cyanopyridine >3-Chloro-2-cyanopyridine ,95%;3-CHLOROPYRIDINE-2-CARBONITRILE;3-CHLORO-2-PYRIDINECARBONITRILE;2-Pyridinecarbonitrile, 3-chloro-
- CBNumber
- CB3127818
- Molecular Formula
- C6H3ClN2
- Formula Weight
- 138.55
- MOL File
- 38180-46-0.mol
2-Cyano-3-chloropyridine Property
- Melting point:
- 81-83°C
- Boiling point:
- 100°C/3mmHg(lit.)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Methanol
- pka
- -2.60±0.10(Predicted)
- form
- Solid
- color
- Light Yellow
- InChI
- InChI=1S/C6H3ClN2/c7-5-2-1-3-9-6(5)4-8/h1-3H
- InChIKey
- YDPLFBIGFQFIDB-UHFFFAOYSA-N
- SMILES
- C1(C#N)=NC=CC=C1Cl
- CAS DataBase Reference
- 38180-46-0(CAS DataBase Reference)
Safety
- Hazard Codes
- T,Xi
- Risk Statements
- 25-36/37/38-20/21/22
- Safety Statements
- 45-36/37-22
- RIDADR
- 2811
- HazardClass
- 6.1
- HazardClass
- IRRITANT-HARMFUL
- PackingGroup
- Ⅲ
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H302Harmful if swallowed
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P309IF exposed or if you feel unwell:
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- C3022
- Product name
- 3-Chloro-2-cyanopyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $16
- Updated
- 2025/07/31
- Product number
- C3022
- Product name
- 3-Chloro-2-cyanopyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $42
- Updated
- 2025/07/31
- Product number
- C962500
- Product name
- 2-Cyano-3-chloropyridine
- Packaging
- 1g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- C8397-02
- Product name
- 2-Cyano-3-chloropyridine
- Packaging
- 250mg
- Price
- $425
- Updated
- 2021/12/16
- Product number
- C962500
- Product name
- 2-Cyano-3-chloropyridine
- Packaging
- 5g
- Price
- $880
- Updated
- 2021/12/16
2-Cyano-3-chloropyridine Chemical Properties,Usage,Production
Chemical Properties
Light Yellow Solid
Uses
2-Cyano-3-chloropyridine (cas# 38180-46-0) is a compound useful in organic synthesis.
Synthesis
7677-24-9
38180-46-0
3-Chloro-2-cyanopyridine (44A, 2.59 g, 20 mmol) was used as starting material and mixed with trimethylmethylsilyl cyanide (5.95 g, 60 mmol), triethylamine (Et3N, 4.05 g, 40 mmol), and acetonitrile (20 mL) in a 250 mL three-necked round-bottom flask. The reaction mixture was refluxed under nitrogen protection for 6 h. Complete consumption of raw materials was confirmed by HPLC analysis. Upon completion of the reaction, the cooled reaction mixture was concentrated under reduced pressure to give a brown semi-solid. The semi-solid was extracted by partitioning with 3N Na2CO3 aqueous solution and dichloromethane (CH2Cl2). The organic layer was washed sequentially with water and brine, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The resulting residue was purified by fast chromatography using 5% ether (Et2O)/dichloromethane (CH2Cl2) as eluent, and the target product 44B was finally obtained as a white crystalline solid (1.84 g, 67% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 7.37 (dd, J = 4.7, 8.4 Hz, 1H), 7.73 (dd, J = 1.4, 8.2 Hz, 1H), 8.47 (dd, J = 1.3, 4.6 Hz, 1H); LC/MS analysis showed m/z 139 [M + H]+.
References
[1] Patent: US2004/19063, 2004, A1
[2] Patent: US2004/181064, 2004, A1
2-Cyano-3-chloropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Cyano-3-chloropyridine manufacturers
- Product
- 2-Cyano-3-chloropyridine 38180-46-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-14
- Product
- 2-Cyano-3-chloropyridine 38180-46-0
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,50kg
- Release date
- 2020-01-18
- Product
- 2-Cyano-3-chloropyridine
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-02