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1-Methyl-1H-pyrazole-4-carbonitrile

Product Name
1-Methyl-1H-pyrazole-4-carbonitrile
CAS No.
66121-71-9
Chemical Name
1-Methyl-1H-pyrazole-4-carbonitrile
Synonyms
N-methyl-4-cyanopyrazole;1-Methyl-4-cyanopyrazole;4-Cyano-1-Methylpyrazole;1-Methyl-Pyrazole-4-carbonitrile;1-Methyl-1H-pyrazol-4-carbonitrile;1H-Pyrazole-4-carbonitrile,1-Methyl;1-METHYL-1H-PYRAZOLE-4-CARBONITRILE;1H-Pyrazole-4-carbonitrile,1-methyl-(9CI);1-methyl-1H-pyrazole-4-carbonitrile(SALTDATA: FREE)
CBNumber
CB31289470
Molecular Formula
C5H5N3
Formula Weight
107.11
MOL File
66121-71-9.mol
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1-Methyl-1H-pyrazole-4-carbonitrile Property

Melting point:
60 °C(Solv: cyclohexane (110-82-7))
Boiling point:
230.2±13.0 °C(Predicted)
Density 
1.12±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
-1.41±0.10(Predicted)
Appearance
White to light yellow Solid
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Safety

HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
B495213
Product name
1-Methyl-1H-pyrazole-4-carbonitrile
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
B495213
Product name
1-Methyl-1H-pyrazole-4-carbonitrile
Packaging
500mg
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
OR939081
Product name
1-Methyl-1H-pyrazole-4-carbonitrile
Purity
95%
Packaging
1g
Price
$125
Updated
2021/12/16
SynQuest Laboratories
Product number
3H37-1-94
Product name
1-Methyl-1H-pyrazole-4-carbonitrile
Purity
95%
Packaging
1g
Price
$200
Updated
2021/12/16
Apolloscientific
Product number
OR939081
Product name
1-Methyl-1H-pyrazole-4-carbonitrile
Purity
95%
Packaging
5g
Price
$335
Updated
2021/12/16
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1-Methyl-1H-pyrazole-4-carbonitrile Chemical Properties,Usage,Production

Synthesis

25016-11-9

66121-71-9

The general procedure for the synthesis of 1-methylpyrazole-4-carbonitrile using 1-methyl-1H-pyrazole-4-carboxaldehyde as starting material was as follows: 1-methyl-1H-pyrazole-4-carboxaldehyde (11.0 g, 0.1 mol), sodium bromate (6.0 g, 0.04 mol) and acetic acid (50 g, 0.83 mol) were mixed in a reaction flask at room temperature. Subsequently, 25% ammonia (12.5 g) and water (100 mL) were added to the mixture. The reaction mixture was heated to 90 °C and after the reaction was observed to be exothermic, the reaction temperature was maintained at 100 °C and the reflux reaction was carried out for 1 h (monitored by TLC until 1-methyl-1H-pyrazole-4-carbaldehyde was fully reacted). Upon completion of the reaction, the reaction solution was cooled to room temperature and poured into ice water for quenching and dilution. The reaction solution was adjusted to neutral with a suitable base solution and subsequently extracted with ethyl acetate and the organic phase was dried over anhydrous sodium sulfate. After concentration of the organic phase, the product was purified by distillation under reduced pressure and recrystallization. The final product was 1-methylpyrazole-4-carbonitrile (10.2 g, 95% yield), which was analyzed by HPLC with a purity of more than 99%.

References

[1] Patent: CN108707113, 2018, A. Location in patent: Paragraph 0017
[2] Russian Journal of General Chemistry, 2012, vol. 82, # 10, p. 1720 - 1723
[3] Zh. Obshch. Khim., 2012, vol. 82, # 10, p. 1716 - 1719,4

1-Methyl-1H-pyrazole-4-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Methyl-1H-pyrazole-4-carbonitrile Suppliers

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View Lastest Price from 1-Methyl-1H-pyrazole-4-carbonitrile manufacturers

Career Henan Chemical Co
Product
1H-Pyrazole-4-carbonitrile,1-methyl-(9CI) 66121-71-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-25

66121-71-9, 1-Methyl-1H-pyrazole-4-carbonitrileRelated Search:

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  • 1H-Pyrazole-4-carbonitrile,1-methyl-(9CI)
  • 1-methyl-1H-pyrazole-4-carbonitrile(SALTDATA: FREE)
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  • 1H-Pyrazole-4-carbonitrile,1-Methyl
  • 4-Cyano-1-Methylpyrazole
  • 1-Methyl-4-cyanopyrazole
  • 1-Methyl-1H-pyrazol-4-carbonitrile
  • 1-METHYL-1H-PYRAZOLE-4-CARBONITRILE
  • N-methyl-4-cyanopyrazole
  • 66121-71-9
  • NITRILE