ChemicalBook > CAS DataBase List > 1H-Indole-3-aceticacid,4-bromo-(9CI)
1H-Indole-3-aceticacid,4-bromo-(9CI)
- Product Name
- 1H-Indole-3-aceticacid,4-bromo-(9CI)
- CAS No.
- 89245-41-0
- Chemical Name
- 1H-Indole-3-aceticacid,4-bromo-(9CI)
- Synonyms
- 4-Bromoindole-3-acetic Acid;4-Bromo-3-indoleacetic acid;4-broMo-1H-indole-3-acetic acid;1H-Indole-3-acetic acid, 4-broMo-;(4-Bromo-1H-indol-3-yl)-acetic acid;2-(4-bromo-1H-indol-3-yl)acetic acid;1H-Indole-3-aceticacid,4-bromo-(9CI)
- CBNumber
- CB31297828
- Molecular Formula
- C10H8BrNO2
- Formula Weight
- 254.08
- MOL File
- 89245-41-0.mol
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1H-Indole-3-aceticacid,4-bromo-(9CI) Property
- Melting point:
- 185-187℃ (DEC.)
- Boiling point:
- 466.0±30.0 °C(Predicted)
- Density
- 1.746
- storage temp.
- 2-8°C
- pka
- 4.27±0.30(Predicted)
- Appearance
- Light yellow to yellow Solid
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- B688755
- Product name
- 2-(4-Bromo-1H-indol-3-yl)aceticAcid
- Packaging
- 100mg
- Price
- $55
- Updated
- 2021/12/16
TRC
- Product number
- B688755
- Product name
- 2-(4-Bromo-1H-indol-3-yl)aceticAcid
- Packaging
- 500mg
- Price
- $165
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB142866
- Product name
- 2-(4-Bromo-1H-indol-3-yl)acetic acid
- Packaging
- 250mg
- Price
- $62.5
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB142866
- Product name
- 2-(4-Bromo-1H-indol-3-yl)acetic acid
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
AK Scientific
- Product number
- W9217
- Product name
- 2-(4-bromo-1H-indol-3-yl)aceticacid
- Packaging
- 250mg
- Price
- $140
- Updated
- 2021/12/16
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1H-Indole-3-aceticacid,4-bromo-(9CI) Chemical Properties,Usage,Production
Synthesis
65018-18-0
89245-41-0
To a dry three-necked flask was added 98.0 kg of 4-bromoindole, 307.0 kg of aluminum trichloride and 500 L of methylene chloride, and 79.0 kg of acetyl chloride was added slowly and dropwise to the three-necked flask. The reaction mixture was heated to 40 °C and kept for 8 hours. Upon completion of the reaction, the mixture was poured into 800 L of ice water, the organic phase was separated and the solvent was recovered to give 1,3-diacetyl-4-bromoindole. Subsequently, 161 kg of morpholine and 40.0 kg of sulfur were added directly to the reaction system, heated to 120 °C and kept for 5 hours. After the rearrangement reaction was completed, 500 L of methanol was added, heated to dissolve, decolorized with activated carbon, filtered and cooled. To the filtrate, 300 L of 70% ethanol and 200 L of 15% sodium hydroxide solution were added and heated to reflux for 4 hours. After completion of the reaction, filter and recover the solvent under vacuum. To the residue, appropriate amount of water was added and the pH was adjusted to 1-2 with dilute hydrochloric acid to precipitate a solid. It was filtered, washed with water to neutral, and finally recrystallized with 60% ethanol to obtain 102.2 kg of 4-bromoindole-3-acetic acid in 85.2% yield.
References
[1] Patent: CN104311469, 2016, B. Location in patent: Paragraph 0070-0072
1H-Indole-3-aceticacid,4-bromo-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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89245-41-0, 1H-Indole-3-aceticacid,4-bromo-(9CI)Related Search:
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1H-Indole-3-aceticacid,4-bromo-(9CI)