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magnolin

Product Name
magnolin
CAS No.
31008-18-1
Chemical Name
magnolin
Synonyms
Maglin;Magnolin;magnolitin;Magnolin-RM;Medioresinol dimethyl ether;Benzene, bis(chloromethyl)dimethyl-;Magnolin, 98%, from Magnolia liliflora Desr.;1H,3H-Furo[3,4-c]furan, 1-(3,4-dimethoxyphenyl);tetrahydro-4-(3,4,5-trimethoxyphenyl)-,(1S,3aR,4S,6aR)-;(1S,3aR,4S,6aR)-1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyp...
CBNumber
CB31335188
Molecular Formula
C23H28O7
Formula Weight
416.46
MOL File
31008-18-1.mol
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magnolin Property

Melting point:
91.4-92.9 °C
Boiling point:
536.9±50.0 °C(Predicted)
Density 
1.178±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Solid
color 
White to Off-White
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Safety

Safety Statements 
24/25
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25123
Product name
Magnolin
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
25123
Product name
Magnolin
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
25123
Product name
Magnolin
Purity
≥98%
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
25123
Product name
Magnolin
Purity
≥98%
Packaging
25mg
Price
$533
Updated
2024/03/01
TRC
Product number
M110395
Product name
Magnolin
Packaging
250mg
Price
$505
Updated
2021/12/16
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magnolin Chemical Properties,Usage,Production

Description

Magnolin, a major component of Magnolia flos (Shin-Yi), inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC50s of 87 nM and 16.5 nM, respectively.

Uses

Magnolin is a lignan extract from Magnoliae Flos, displaying anti-asthma and anti-inflammatory activity.

in vitro

Magnolin is a natural compound abundantly found in Magnolia flos, which has been traditionally used in oriental medicine to treat headaches, nasal congestion and anti-inflammatory reactions. Magnolin targets the active pockets of ERK1 and ERK2, which are important signaling molecules in cancer cell metastasis. Magnolin inhibits NF-κB transactivation activity by suppressing the ERKs/RSK2 signaling pathway. Magnolin inhibits the production of tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) by inhibiting extracellular signal-regulated kinases (ERKs), which are key signaling molecules in the regulation of cell proliferation, transformation and cancer cell metastasis. JB6 Cl41 cell migration enhanced by EGF treatment is dramatically suppressed by Magnolin treatment in a dose-dependent manner. Magnolin inhibits ERK1/2/RSK2 signaling-mediated IκBα phosphorylation at Ser32, resulting in the inhibition of NF-κB activation and cell migration.

magnolin Preparation Products And Raw materials

Raw materials

Preparation Products

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magnolin Suppliers

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View Lastest Price from magnolin manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
magnolin 31008-18-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-07-29
Shanghai Standard Technology Co., Ltd.
Product
Magnolin 31008-18-1
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-10-12
Shanghai Standard Technology Co., Ltd.
Product
Magnolin 31008-18-1
Price
US $0.00/mg
Min. Order
5mg
Purity
Analytical Standard
Supply Ability
10 g
Release date
2019-10-12

31008-18-1, magnolinRelated Search:

Ammothamnine Verbascoside FORSYTHIN Rhamnosylvitexin AURANTIO-OBTUSIN ARTEMISININ Taxifolin Hydroxysafflor yellow A FARGESIN Nsc150443 MAGNOFLORINE IODIDE, (+)-(RG) (+)-MAGNOFLORINE IODIDE ENTERODIOL magnolin (+)-LARICIRESINOL (+)-PINORESINOL SECOISOLARICIRESINOL Terameprocol

  • 1H,3H-Furo[3,4-c]furan, 1-(3,4-dimethoxyphenyl)
  • Medioresinol dimethyl ether
  • tetrahydro-4-(3,4,5-trimethoxyphenyl)-,(1S,3aR,4S,6aR)-
  • Magnolin
  • Maglin
  • Magnolin, 98%, from Magnolia liliflora Desr.
  • (1S,3aR,4S,6aR)-1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan
  • 1H,3H-Furo[3,4-c]furan, 1-(3,4-dimethoxyphenyl)tetrahydro-4-(3,4,5-trimethoxyphenyl)-, (1S,3aR,4S,6aR)-
  • (3S,3aR,6S,6aR)-3-(3,4-dimethoxyphenyl)-6-(3,4,5-trimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan
  • (1S,3aR,4S,6aR)-1-(3,4-dimethoxyphenyl)-4-(3,4,5-trimethoxyp...
  • magnolitin
  • Magnolin-RM
  • Benzene, bis(chloromethyl)dimethyl-
  • 31008-18-1
  • Miscellaneous Natural Products