annonacin

Product Name: annonacin
CAS No.: 111035-65-5
Chemical Name: annonacin
Synonyms: annonacin;(+/-) Annonacin (Mixture of Isomers);(5S)-5-Methyl-3-[(2R,8R,13R)-2,8,13-trihydroxy-13-[[(2R)-tetrahydro-5α-[(R)-1-hydroxytridecyl]furan]-2β-yl]tridecyl]-2(5H)-furanone;2(5H)-Furanone, 5-methyl-3-[(2R,8R,13R)-2,8,13-trihydroxy-13-[(2R,5R)-tetrahydro-5-[(1R)-1-hydroxytridecyl]-2-furanyl]tridecyl]-, (5S)-
CBNumber: CB31344614
Molecular Formula: C35H64O7
Formula Weight: 596.88
MOL File: 111035-65-5.mol

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annonacin Property

Melting point:: 69-71 °C
Boiling point:: 756.2±55.0 °C(Predicted)
Density: 1.050±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 10 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml
form: A powder
pka: 14.45±0.20(Predicted)
color: White to off-white
InChIKey: XNODZYPOIPVPRF-CGWDHHCXSA-N
SMILES: O1[C@@H](C)C=C(C[C@H](O)CCCCC[C@@H](O)CCCC[C@@H](O)[C@H]2CC[C@H]([C@H](O)CCCCCCCCCCCC)O2)C1=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22415
Product name: Annonacin
Purity: ≥98%
Packaging: 500μg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 22415
Product name: Annonacin
Purity: ≥98%
Packaging: 1mg
Price: $243
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: PXT0005386
Product name: ANNONACIN
Purity: 95.00%
Packaging: 5MG
Price: $495.12
Updated: 2021/12/16

ChemScene

Product number: CS-0023456
Product name: Annonacin
Packaging: 5mg
Price: $850
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 17345
Product name: Annonacin
Packaging: 5mg
Price: $1650
Updated: 2021/12/16

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annonacin Chemical Properties,Usage,Production

Uses

(+/-) Annonacin is used as a modulation of cancer signaling pathway(s) in two -stage mouse skin tumorigenesis by annonacin. Its also used in the evaluation of nutritional characteristics and bioactive compounds of Annona muricata-yogurt and Annona muricata-frozen dessert.

in vivo

Annonacin (0-9 mg/kg; Subcutaneous osmotic pump; 3 days) increases tau phosphorylation in R406W^+/+ mice ^[3].
Annonacin (85 nM/100 μL; Topical application; Twice a week for 22 weeks) has anti-cancer effect in mouse model of skin tumor ^[4].

Animal Model:	R406W^+/+ transgenic mice^[3]
Dosage:	0, 6 and 9 mg/kg/day
Administration:	Subcutaneous osmotic pump; 3 days
Result:	Increased the number of neurons with phosphorylated tau in the somatodendritic compartment in several brain areas. Increased the levels of phosphorylated tau protein. Increased in total tau protein without increase in tau mRNA, but reduced proteasomal proteolytic activity. Increased the levels of different tau kinases. Significantly increased the ratio of p25/p35.

Animal Model:	DMBA (HY-W011845)/TPA treated female ICR mice aged 6-7 weeks old^[4]
Dosage:	85 nM/100 uL
Administration:	Topical application; Twice a week for 22 weeks
Result:	Significantly increased the tumor latency period and reduced the tumor incidence, tumor burden and tumor volume, respectively. Suppressed tumorigenesis manifested by significant reduction of hyperkeratosis, dermal papillae and number of keratin pearls on skin tissues. Showed no toxicity to the liver and kidneys.

annonacin Preparation Products And Raw materials

Raw materials

Preparation Products

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annonacin Suppliers

China 73 India 1 United States 10 USA 1 Global 85

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5645
Advantage: 65

Sichuan BioCrick Biotech Co., Ltd

Tel: 28-86-28-8543-3893 13260669172
Email: sales@biocrick.com
Country: China
ProdList: 5020
Advantage: 58

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8144
Advantage: 55

ALB Technology Limited

Tel: 702-983-3769
Fax: 702-983-3769
Email: sales@albtechnology.com
Country: United States
ProdList: 2993
Advantage: 55

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 6905
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

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View Lastest Price from annonacin manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: annonacin 111035-65-5
Price: US $1.00-4.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2025-05-14

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annonacin

(5S)-5-Methyl-3-[(2R,8R,13R)-2,8,13-trihydroxy-13-[[(2R)-tetrahydro-5α-[(R)-1-hydroxytridecyl]furan]-2β-yl]tridecyl]-2(5H)-furanone

2(5H)-Furanone, 5-methyl-3-[(2R,8R,13R)-2,8,13-trihydroxy-13-[(2R,5R)-tetrahydro-5-[(1R)-1-hydroxytridecyl]-2-furanyl]tridecyl]-, (5S)-

(+/-) Annonacin (Mixture of Isomers)

111035-65-5

Csub35subHsub64subOsub7sub