ChemicalBook > CAS DataBase List > [3-(Dimethylamino)propyl]triphenylphosphonium bromide hydrobromide

[3-(Dimethylamino)propyl]triphenylphosphonium bromide hydrobromide

Product Name: [3-(Dimethylamino)propyl]triphenylphosphonium bromide hydrobromide
CAS No.: 27710-82-3
Chemical Name: [3-(Dimethylamino)propyl]triphenylphosphonium bromide hydrobromide
Synonyms: (3-DIMETHYLAMINOPROPYL)TRIPHENYLPHOSPHONIUM BROMIDE HYDROBROMIDE;orOlopatadine;forOlopatadine;[3-(Dimethylamino)pr;Olopatadine Impurity 8 HBr;Olopatadine Impurity 13 HBr;Olatadine Impurity 17(hydrobromide);(3-DIMETHYLAMINOPROPYL)-TRIPHENYL-PHOSPH;triphenylphosphoniuM broMide hydrobroMide;[3-(DiMethylaMino)propyl]triphenylphosphoniuM broM
CBNumber: CB3135473
Molecular Formula: C23H28Br2NP
Formula Weight: 509.27
MOL File: 27710-82-3.mol

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[3-(Dimethylamino)propyl]triphenylphosphonium bromide hydrobromide Property

Melting point:: 283-285 °C
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: Off-White
Stability:: Hygroscopic
InChI: InChI=1S/C23H27NP.2BrH/c1-24(2)19-12-20-25(21-13-6-3-7-14-21,22-15-8-4-9-16-22)23-17-10-5-11-18-23;;/h3-11,13-18H,12,19-20H2,1-2H3;2*1H/q+1;;/p-1
InChIKey: NEQVFHFOWYYPBS-UHFFFAOYSA-M
SMILES: [P+](C1C=CC=CC=1)(C1C=CC=CC=1)(C1C=CC=CC=1)CCCN(C)C.[Br-].Br
CAS DataBase Reference: 27710-82-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 3-10

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H401Toxic to aquatic life

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: D495303
Product name: [3-(Dimethylamino)propyl]triphenylphosphoniumBromideHydrobromide
Packaging: 5g
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 097494
Product name: (3-(Dimethylamino)propyl)triphenyl-phosphonium bromide hydrobromide
Purity: 95+%
Packaging: 1g
Price: $87
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD147012
Product name: (3-Dimethylaminopropyl)triphenylphosphonium bromide hydrobromide
Packaging: 50g
Price: $105
Updated: 2021/12/16

AK Scientific

Product number: N760
Product name: [3-(Dimethylamino)propyl]triphenylphosphoniumbromidehydrobromide
Packaging: 10g
Price: $30
Updated: 2021/12/16

AK Scientific

Product number: J52092
Product name: [3-(Dimethylamino)propyl]triphenylphosphoniumbromidehydrobromide
Packaging: 25g
Price: $46
Updated: 2021/12/16

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[3-(Dimethylamino)propyl]triphenylphosphonium bromide hydrobromide Chemical Properties,Usage,Production

Uses

(3-(Dimethylamino)propyl)triphenylphosphonium bromide is used as a reactant for preparing chlorpheniramine analogs reverse chloroquine resistance in Plasmodium falciparum by inhibiting PfCRT.

Synthesis

3607-17-8

124-40-3

27710-82-3

To a suspension of (3-bromopropyl)triphenylphosphonium bromide (1.0 g, 2.1 mmol) in ethanol (5 mL) was slowly added 40% aqueous dimethylamine (3 mL) at room temperature. The reaction mixture was transferred to a sealed microwave reaction tube and heated at 100 °C with stirring for 30 min. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified by recrystallization in acetonitrile to afford [3-(dimethylamino)propyl]triphenylphosphonium bromide hydrobromide (0.90 g, 82% yield) as a white solid, which was used directly in the subsequent reaction.ESI MS m/z 348.3 (corresponding to Ph3PCH2CH2CH2CH2NMe2+ ions).

References

[1] Patent: WO2012/79017, 2012, A1. Location in patent: Page/Page column 68
[2] Patent: US2007/232814, 2007, A1. Location in patent: Page/Page column 24

[3-(Dimethylamino)propyl]triphenylphosphonium bromide hydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from [3-(Dimethylamino)propyl]triphenylphosphonium bromide hydrobromide manufacturers

Anhuyan (Hainan) Biotechnology Co., LTD

Product: [3-(Dimethylamino)propyl]triphenylphosphonium bromide hydrobromide 7710-82-3
Price: US $0.00-0.00/kg
Min. Order: 0.001kg
Purity: 99.99%
Supply Ability: 200000T
Release date: 2025-06-16

Hebei Chuanghai Biotechnology Co., Ltd

Product: [3-(Dimethylamino)propyl]triphenylphosphonium bromide hydrobromide 27710-82-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-21

Hebei Chuanghai Biotechnology Co., Ltd

Product: [3-(Dimethylamino)propyl]triphenylphosphonium bromide hydrobromide 27710-82-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-29

27710-82-3, [3-(Dimethylamino)propyl]triphenylphosphonium bromide hydrobromideRelated Search:

Scopolamine hydrobromide Sodium bromate Clidinium bromide Hydrogen bromide Propyl gallate (FORMYLMETHYLENE)TRIPHENYLPHOSPHORANE Propyl butyrate HYOSCINE N BUTYL BROMIDE BP Ethidium bromide DEXTROMETHORPHAN HYDROBROMIDE Methyl bromide Olopatadine 3-((Dimethylamino)propyl)triphenylphosphonium bromide (3-AMINOPROPYL)DIPHENYLPHOSPHINE [3-(Dimethylamino)propyl]triphenylphosphonium bromide hydrobromide Bromide

(3-DIMETHYLAMINOPROPYL)TRIPHENYLPHOSPHONIUM BROMIDE HYDROBROMIDE 98%

(3-DIMETHYLAMINOPROPYL)TRIPHENYLPHOSPHONIUM BROMIDE HBR

(3-DIMETHYLAMINOPROPYL)TRIPHENYLPHOSPHONIUM BROMIDE HYDROBROMIDE

[3-(Dimethylamino)pr

[3-(DiMethylaMino)propyl]triphenylphosphoniuM broM

triphenylphosphoniuM broMide hydrobroMide

(3-(DiMethylaMino)propyl)triphenylphosphoniuM broMide hydrobroMide puruM

(3-diMethylaMinopropyl)triphenylphospho-niuM broMo hydrobroMide

[3-(diMethylaMino)propyl]triphenylphosphaniuM hydrobroMide broMide

3-(4-bromo-2,3-diphenylphenyl)-N,N-dimethyl-1-propanamine hydrobromide

[3-(Dimethylamino)propyl]triphenylphosphonium bromide Hcl

orOlopatadine

PHOSPHONIUM, [3-(DIMETHYLAMINO)PROPYL]TRIPHENYL BROMIDE HYDROBROMIDE

(3-dimethylaminopropyl)triphenylphospho-nium brom.hydrobromi

PHOSPHONIUM,[3-(DIMETHYLAMINO)PROPYL]TRIPHENYL BROMIDE HBr

[3-(Dimethylamino)propyl]triphenyl bromide hydrobromide

(3-DIMETHYLAMINOPROPYL)-TRIPHENYL-PHOSPH

PHOSPHONIUM, [3-(DIMETHYLAMINO)PROPYL]TRIPHENYL BROMIDE HYDROBROMIDE (FOR OLOPATADINE)

[3-(Dimethylamino)propyl] triphenylphosphonium bromide hydrobromide ( For Olopatadine )

[3-(Dimethylamino)propyl]triphenylphosphonium bromide hydrobromide (Olopatadine)

forOlopatadine

3-(Dimethylamino)Propyl]Triphenylphosphonium Bromide Hydrobromide,>98%

[3-(Dimethylamino)propyl]triphenylphosphonium bromide hydrobromide ISO 9001：2015 REACH

[3-(Dimethylamino)propyl]triphenyl-bromide phosphonium hydrobromide

Olopatadine Impurity 8 HBr

(3-dimethylaminopropyl)triphenylphospho-nium bromo hydrobrom...

Hydrobromide (3-(dimethylamino)propyl)triphenylphosphonium bromide

3- (dimethylamino) propyl] triphenylphosphine bromide hydrobromide

Olatadine Impurity 17(hydrobromide)

Olopatadine Impurity 13 HBr

[3-(dimethylamino)propyl](triphenyl)phosphonium bromide hydrobromide (1:1:1)

27710-82-3

7710-82-3

C23H27NPBrHBr

CH32NCH2CH2CH2PC6H53BrHBr

C23H28Br2NP

C23H27BrPHBr

C23H27NPBrBrH

C-C Bond Formation

Synthetic Reagents

Wittig Reagents

Olefination

APIs Intermediate