ChemicalBook > CAS DataBase List > 2-Hydroxy-4-methylpyridine-3-carbonitrile

2-Hydroxy-4-methylpyridine-3-carbonitrile

Product Name: 2-Hydroxy-4-methylpyridine-3-carbonitrile
CAS No.: 93271-59-1
Chemical Name: 2-Hydroxy-4-methylpyridine-3-carbonitrile
Synonyms: 2-hydroxy-4-Methylnicotinonitrile;3-Cyano-4-methyl-2-pyridone;3-Cyano-2-hydroxy-4-methylpyridine;4-methyl-2-oxo-1H-pyridine-3-carbonitrile;2-Hydroxy-4-methylpyridine-3-carbonitrile;4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile;1,2-dihydro-4-Methyl-2-oxopyridine-3-carbonitrile;1,2-dihydro-4-Methyl-2-oxo-3-Pyridinecarbonitrile;3-Pyridinecarbonitrile,1,2-dihydro-4-Methyl-2-oxo-;4-methyl-2-oxo-1H-pyridine-3-carbonitrile - [M87955]
CBNumber: CB31457086
Molecular Formula: C7H6N2O
Formula Weight: 134.14
MOL File: 93271-59-1.mol

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2-Hydroxy-4-methylpyridine-3-carbonitrile Property

Melting point:: 234.7-236.1 °C
Boiling point:: 337.7±35.0 °C(Predicted)
Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
pka: 8.96±0.10(Predicted)
Appearance: Light yellow to yellow Solid
InChI: InChI=1S/C7H6N2O/c1-5-2-3-9-7(10)6(5)4-8/h2-3H,1H3,(H,9,10)
InChIKey: XSJRLWNOZDULKJ-UHFFFAOYSA-N
SMILES: C1(=O)NC=CC(C)=C1C#N

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C987913
Product name: 3-Cyano-4-methyl-2-pyridone
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C987913
Product name: 3-Cyano-4-methyl-2-pyridone
Packaging: 1g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD150345
Product name: 1,2-Dihydro-4-methyl-2-oxo-3-pyridinecarbonitrile
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD150345
Product name: 1,2-Dihydro-4-methyl-2-oxo-3-pyridinecarbonitrile
Packaging: 500mg
Price: $120
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD150345
Product name: 1,2-Dihydro-4-methyl-2-oxo-3-pyridinecarbonitrile
Packaging: 1g
Price: $180
Updated: 2021/12/16

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2-Hydroxy-4-methylpyridine-3-carbonitrile Chemical Properties,Usage,Production

Synthesis

5436-21-5

107-91-5

93271-59-1

Ammonium acetate (79.3 mg, 1.03 mmol) and acetic acid (0.6 mL) were added to anhydrous toluene (12.4 mL) as 4,4-dimethoxy-2-butanone (2.0 g, 15.13 mmol) and cyanoacetamide (1.6 g, 18.92 mmol) in an anhydrous toluene (12.4 mL) assembled in a Dean-Stark device and stirred and refluxed for 8 hr to remove the resulting water. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure, and the residual oily substance was cooled to room temperature and ethanol (7.0 mL) was added at 25 °C with stirring. Subsequently, 50% sulfuric acid (2.6 mL) was added slowly and the mixture was heated at 50 °C with stirring for 3 hours. After the reaction mixture was cooled to 5 °C, water (1.3 mL) was slowly added. The resulting brown solid was purified by crystallization in ethanol to give 2-hydroxy-3-cyano-4-methylpyridine (0.900 g, yield: 45%); melting point: 233-236 °C. 1H NMR (400 MHz, DMSO-d6): δ 12.58 (br s, 1H, NH), 8.04 (d, J = 7.4 Hz, 1H, H-6), 6.24 ( d, J = 7.4 Hz, 1H, H-5), 2.31 (s, 3H, CH3).

References

[1] European Journal of Medicinal Chemistry, 2018, vol. 154, p. 155 - 171

2-Hydroxy-4-methylpyridine-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Hydroxy-4-methylpyridine-3-carbonitrile manufacturers

Shanghai Rlavie Technology Co ltd

Product: 2-Hydroxy-4-methylpyridine-3-carbonitrile 93271-59-1
Price: US $0.00-0.00/kg
Min. Order: 0.0001kg
Purity: 98%min
Supply Ability: 100kgs/month
Release date: 2022-05-10

Dideu Industries Group Limited

Product: 2-Hydroxy-4-methylpyridine-3-carbonitrile 93271-59-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-26

Career Henan Chemical Co

Product: 2-Hydroxy-4-methylpyridine-3-carbonitrile 93271-59-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-25

93271-59-1, 2-Hydroxy-4-methylpyridine-3-carbonitrileRelated Search:

1-Ethyl-6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 1,4-Dimethyl-3-cyano-6-hydroxypyrid-2-one ETHYL 2-(6'-CYANO-5'-OXO-3',5'-DIHYDRO-2'H-SPIRO[[1,3]DIOXOLANE-2,1'-INDOLIZINE]-7'-YL)ACETATE 2-HYDROXY-4-METHOXYMETHYL-6-METHYLNICOTINONITRILE 3-Cyano-4,6-dimethyl-2-hydroxypyridine 3-Cyano-2,6-dihydroxy-4-methylpyridine 7'-METHYL-5'-OXO-3',5'-DIHYDRO-2'H-SPIRO[[1,3]DIOXOLANE-2,1'-INDOLIZINE]-6'-CARBONITRILE N-Butyl-3-cyano-6-hydroxy-4-methyl-2-pyridone QUINOXALIN-5-AMINE 2-HYDROXY-6-(2-THIENYL)-4-(TRIFLUOROMETHYL)NICOTINONITRILE 1-AMINO-4,6-DIMETHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBONITRILE 6-hydroxy-1-(3-methoxypropyl)-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 5-CHLORO-2-HYDROXY-4,6-DIMETHYLNICOTINONITRILE 5-Bromo-2-hydroxy-4,6-dimethyl-nicotinonitrile 2-HYDROXY-4,5,6-TRIMETHYLNICOTINONITRILE ETHYL 3-CYANO-2-HYDROXY-6-METHYLISONICOTINATE 7-METHYL-1,5-DIOXO-1,2,3,5-TETRAHYDRO-INDOLIZINE-6-CARBONITRILE METHYL 6-CYANO-1-HYDROXY-7-METHYL-5-OXO-3,5-DIHYDROINDOLIZINE-2-CARBOXYLATE

2-Hydroxy-4-methylpyridine-3-carbonitrile

3-Cyano-4-methyl-2-pyridone

4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

2-hydroxy-4-Methylnicotinonitrile

1,2-dihydro-4-Methyl-2-oxo-3-Pyridinecarbonitrile

1,2-dihydro-4-Methyl-2-oxopyridine-3-carbonitrile

3-Cyano-2-hydroxy-4-methylpyridine

3-Pyridinecarbonitrile,1,2-dihydro-4-Methyl-2-oxo-

4-methyl-2-oxo-1H-pyridine-3-carbonitrile

2-Hydroxy-4-methylpyridine-3-carbonitrile ISO 9001：2015 REACH

4-methyl-2-oxo-1H-pyridine-3-carbonitrile - [M87955]

93271-59-1

Pyridine