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2-Hydroxy-4-methylpyridine-3-carbonitrile

Product Name
2-Hydroxy-4-methylpyridine-3-carbonitrile
CAS No.
93271-59-1
Chemical Name
2-Hydroxy-4-methylpyridine-3-carbonitrile
Synonyms
2-hydroxy-4-Methylnicotinonitrile;3-Cyano-4-methyl-2-pyridone;3-Cyano-2-hydroxy-4-methylpyridine;4-methyl-2-oxo-1H-pyridine-3-carbonitrile;2-Hydroxy-4-methylpyridine-3-carbonitrile;4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile;1,2-dihydro-4-Methyl-2-oxopyridine-3-carbonitrile;1,2-dihydro-4-Methyl-2-oxo-3-Pyridinecarbonitrile;3-Pyridinecarbonitrile,1,2-dihydro-4-Methyl-2-oxo-;4-methyl-2-oxo-1H-pyridine-3-carbonitrile - [M87955]
CBNumber
CB31457086
Molecular Formula
C7H6N2O
Formula Weight
134.14
MOL File
93271-59-1.mol
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2-Hydroxy-4-methylpyridine-3-carbonitrile Property

Melting point:
234.7-236.1 °C
Boiling point:
337.7±35.0 °C(Predicted)
Density 
1.20±0.1 g/cm3(Predicted)
storage temp. 
Storage temp. 2-8°C
pka
8.96±0.10(Predicted)
Appearance
Light yellow to yellow Solid
InChI
InChI=1S/C7H6N2O/c1-5-2-3-9-7(10)6(5)4-8/h2-3H,1H3,(H,9,10)
InChIKey
XSJRLWNOZDULKJ-UHFFFAOYSA-N
SMILES
C1(=O)NC=CC(C)=C1C#N
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C987913
Product name
3-Cyano-4-methyl-2-pyridone
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
C987913
Product name
3-Cyano-4-methyl-2-pyridone
Packaging
1g
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD150345
Product name
1,2-Dihydro-4-methyl-2-oxo-3-pyridinecarbonitrile
Packaging
250mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD150345
Product name
1,2-Dihydro-4-methyl-2-oxo-3-pyridinecarbonitrile
Packaging
500mg
Price
$120
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD150345
Product name
1,2-Dihydro-4-methyl-2-oxo-3-pyridinecarbonitrile
Packaging
1g
Price
$180
Updated
2021/12/16
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2-Hydroxy-4-methylpyridine-3-carbonitrile Chemical Properties,Usage,Production

Synthesis

5436-21-5

107-91-5

93271-59-1

Ammonium acetate (79.3 mg, 1.03 mmol) and acetic acid (0.6 mL) were added to anhydrous toluene (12.4 mL) as 4,4-dimethoxy-2-butanone (2.0 g, 15.13 mmol) and cyanoacetamide (1.6 g, 18.92 mmol) in an anhydrous toluene (12.4 mL) assembled in a Dean-Stark device and stirred and refluxed for 8 hr to remove the resulting water. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure, and the residual oily substance was cooled to room temperature and ethanol (7.0 mL) was added at 25 °C with stirring. Subsequently, 50% sulfuric acid (2.6 mL) was added slowly and the mixture was heated at 50 °C with stirring for 3 hours. After the reaction mixture was cooled to 5 °C, water (1.3 mL) was slowly added. The resulting brown solid was purified by crystallization in ethanol to give 2-hydroxy-3-cyano-4-methylpyridine (0.900 g, yield: 45%); melting point: 233-236 °C. 1H NMR (400 MHz, DMSO-d6): δ 12.58 (br s, 1H, NH), 8.04 (d, J = 7.4 Hz, 1H, H-6), 6.24 ( d, J = 7.4 Hz, 1H, H-5), 2.31 (s, 3H, CH3).

References

[1] European Journal of Medicinal Chemistry, 2018, vol. 154, p. 155 - 171

2-Hydroxy-4-methylpyridine-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Hydroxy-4-methylpyridine-3-carbonitrile Suppliers

China 107 France 1 India 1 Ukraine 1 United Kingdom 2 United States 11 Global 123
Ambinter
Tel
--
Fax
--
Email
contact@ambinter.com
Country
France
ProdList
1648
Advantage
60
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View Lastest Price from 2-Hydroxy-4-methylpyridine-3-carbonitrile manufacturers

Shanghai Rlavie Technology Co ltd
Product
2-Hydroxy-4-methylpyridine-3-carbonitrile 93271-59-1
Price
US $0.00-0.00/kg
Min. Order
0.0001kg
Purity
98%min
Supply Ability
100kgs/month
Release date
2022-05-10
Dideu Industries Group Limited
Product
2-Hydroxy-4-methylpyridine-3-carbonitrile 93271-59-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-09-26
Career Henan Chemical Co
Product
2-Hydroxy-4-methylpyridine-3-carbonitrile 93271-59-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-12-25

93271-59-1, 2-Hydroxy-4-methylpyridine-3-carbonitrileRelated Search:

1-Ethyl-6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 1,4-Dimethyl-3-cyano-6-hydroxypyrid-2-one ETHYL 2-(6'-CYANO-5'-OXO-3',5'-DIHYDRO-2'H-SPIRO[[1,3]DIOXOLANE-2,1'-INDOLIZINE]-7'-YL)ACETATE 2-HYDROXY-4-METHOXYMETHYL-6-METHYLNICOTINONITRILE 3-Cyano-4,6-dimethyl-2-hydroxypyridine 3-Cyano-2,6-dihydroxy-4-methylpyridine 7'-METHYL-5'-OXO-3',5'-DIHYDRO-2'H-SPIRO[[1,3]DIOXOLANE-2,1'-INDOLIZINE]-6'-CARBONITRILE N-Butyl-3-cyano-6-hydroxy-4-methyl-2-pyridone QUINOXALIN-5-AMINE 2-HYDROXY-6-(2-THIENYL)-4-(TRIFLUOROMETHYL)NICOTINONITRILE 1-AMINO-4,6-DIMETHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBONITRILE 6-hydroxy-1-(3-methoxypropyl)-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 5-CHLORO-2-HYDROXY-4,6-DIMETHYLNICOTINONITRILE 5-Bromo-2-hydroxy-4,6-dimethyl-nicotinonitrile 2-HYDROXY-4,5,6-TRIMETHYLNICOTINONITRILE ETHYL 3-CYANO-2-HYDROXY-6-METHYLISONICOTINATE 7-METHYL-1,5-DIOXO-1,2,3,5-TETRAHYDRO-INDOLIZINE-6-CARBONITRILE METHYL 6-CYANO-1-HYDROXY-7-METHYL-5-OXO-3,5-DIHYDROINDOLIZINE-2-CARBOXYLATE

  • 2-Hydroxy-4-methylpyridine-3-carbonitrile
  • 3-Cyano-4-methyl-2-pyridone
  • 4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
  • 2-hydroxy-4-Methylnicotinonitrile
  • 1,2-dihydro-4-Methyl-2-oxo-3-Pyridinecarbonitrile
  • 1,2-dihydro-4-Methyl-2-oxopyridine-3-carbonitrile
  • 3-Cyano-2-hydroxy-4-methylpyridine
  • 3-Pyridinecarbonitrile,1,2-dihydro-4-Methyl-2-oxo-
  • 4-methyl-2-oxo-1H-pyridine-3-carbonitrile
  • 2-Hydroxy-4-methylpyridine-3-carbonitrile ISO 9001：2015 REACH
  • 4-methyl-2-oxo-1H-pyridine-3-carbonitrile - [M87955]
  • 93271-59-1
  • Pyridine