Brand Name(s) in US
ChemicalBook > CAS DataBase List > Ticarcillin disodium salt

Ticarcillin disodium salt

Brand Name(s) in US
Product Name
Ticarcillin disodium salt
CAS No.
4697-14-7
Chemical Name
Ticarcillin disodium salt
Synonyms
TICARCILLIN DISODIUM;Ticarcillin sodium;TICAR;Aerugipen;ticarpen;Ticillin;Ticalpenin;Neoanabactyl;Timentin sodium;Timentin, ?>99.0%
CBNumber
CB3147339
Molecular Formula
C15H17N2NaO6S2
Formula Weight
408.42
MOL File
4697-14-7.mol
More
Less

Ticarcillin disodium salt Property

Melting point:
>173°C (dec.)
storage temp. 
2-8°C
solubility 
H2O: soluble50mg/mL
form 
powder
color 
white to light yellow
Merck 
13,9505
Stability:
Moisture sensitive
InChIKey
ZBBCUBMBMZNEME-QBGWIPKPSA-L
CAS DataBase Reference
4697-14-7(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36/37/38-42-43-42/43
Safety Statements 
26-36/37
WGK Germany 
2
RTECS 
XM9410000
HS Code 
2941100000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T5639
Product name
Ticarcillin disodium salt
Purity
≥95%
Packaging
1g
Price
$224
Updated
2024/03/01
Alfa Aesar
Product number
J67144
Product name
Ticaracillin disodium salt, 50 mg/ml in distilled water
Purity
sterile-filtered
Packaging
1ml
Price
$63.5
Updated
2023/06/20
Alfa Aesar
Product number
J67144
Product name
Ticaracillin disodium salt, 50 mg/ml in distilled water
Purity
sterile-filtered
Packaging
5x1ml
Price
$134
Updated
2021/12/16
Cayman Chemical
Product number
26065
Product name
Ticarcillin (sodium salt)
Packaging
1g
Price
$51
Updated
2024/03/01
Cayman Chemical
Product number
26065
Product name
Ticarcillin (sodium salt)
Packaging
25g
Price
$758
Updated
2024/03/01
More
Less

Ticarcillin disodium salt Chemical Properties,Usage,Production

Brand Name(s) in US

Ticar, Ticillin

Description

Ticarcillin is a semisynthetic β-lactam antibiotic. It is active against P. aeruginosa, E. coli, P. mirabilis, P. rettgeri, and K. aerogenes (MICs = 4-125 μg/ml). Topical administration of ticarcillin (2.5 mg per eye) reduces P. aeruginosa colony count in rabbit eye. Formulations containing ticarcillin have been used in the treatment of a variety of bacterial infections.

Chemical Properties

Ticarcillin disodium salt is White Solid

Originator

Ticar,Beecham,US,1976

Uses

coccidiostat

Uses

The disodium salt of Ticarcillin, a carboxypenicillin belonging to the beta-lactam class of antibiotics. Ticarcillin is an injectable antibiotic used in the treatment of infections caused by gram-negative bacteria, particularly Pseudomonas aeruginosa.

Definition

ChEBI: Ticarcillin disodium is an organic sodium salt. It contains a ticarcillin(2-).

Manufacturing Process

A mixture of monobenzyl-3-thienylmalonate (1.38 g, 5 mmol) and thionyl chloride (2.5 ml) was warmed at 50°C to 55°C for 1 hour, then at 60°C to 65°C for 10 minutes. The excess of thionyl chloride was removed in vacuo at not more than 30°C, the last traces being removed by codistillation with dry benzene (1 ml) under high vacuum, leaving monobenzyl3-thienylmalonyl chloride as a yellow oil.
The acid chloride obtained as described above was dissolved in dry acetone (10 ml) and added in a steady stream to a stirred solution of 6- aminopenicillanic acid (1.08 g, 5 mmol) in a mixture of N sodium bicarbonate (15 ml) and acetone (5 ml). After the initial reaction the reaction mixture was stirred at room temperature for 45 minutes, then washed with ether (3 x 25 ml). Acidification of the aqueous solution with N hydrochloric acid (11 ml) to pH 2 and extraction with ether (3 x 15 ml) gave an ethereal extract which was decolorized with a mixture of activated charcoal and magnesium sulfate for 5 minutes.
The resulting pale yellow ethereal solution was shaken with sufficient N sodium bicarbonate (4 ml) to give an aqueous extract of pH 7 to 7.5. This extract was concentrated to syrup at low temperature and pressure, then isopropanol was added with stirring until the mixture contained about 10% water.
Crystallization was initiated, and completed at about 0°C overnight, to give the sodium salt of α-(benzyloxycarbonyl)-3-thienylmethylpenicillin as white crystals in 50% weight yield. This product was estimated by colorimetric assay with hydroxylamine to contain 91% of the anhydrous sodium salt. A solution of the sodium salt of α-(benzyloxycarbonyl)-3- thienylmethylpenicillin (2.13 g, 4.3 mmol) in water (30 ml) was added to a suspension of 5% palladium on calcium carbonate (10.65 g) in water (32 ml) which had been prehydrogenated for 1 hour.
The mixture was then hydrogenated at just above atmospheric pressure for 1 1/2 hours and filtered through a Dicalite bed. The clear filtrate was evaporated at low temperature and pressure, and the residue dried in vacuo over phosphorus pentoxide, to give 1.64 g of the salt of α-(3- thienyl)methylpenicillin as a white solid. Colorimetric assay with hydroxylamine showed this salt to contain 94% of the anhydrous penicillin. Paper chromatography showed complete reduction of the benzyl group.

Therapeutic Function

Antibiotic

General Description

Ticarcillin was synthesized by Beecham Research Laboratories in 1971. The phenyl residue of carbenicillin was replaced by the 3-thienyl moiety. Ticarcillin shows almost the same activity as carbenicillin against gram-positive bacteria and a twofold higher activity against gram-negative bacteria. Its in vivo activity against Pseudomonas aeruginosa infections in mice is fourfold higher than that of sulbenicillin. Ticarcillin is used to treat sepsis, urinary tract infections, and serious Pseudomonas aeruginosa, Escherichia coli, Proteus, and Enterobacter infections in leukemic and other cancer patients.

Ticarcillin disodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Ticarcillin disodium salt Suppliers

Hubei widely chemical technology Co., Ltd.
Tel
027-83991130 18627774460
Fax
027-83991130
Email
1718093273@QQ.COM
Country
China
ProdList
1879
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52693
Advantage
58
Jiangxi ravel Biotechnology Co.,Ltd
Tel
185-0276-2003 18502762003;
Email
435918333@qq.com
Country
China
ProdList
2312
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19179
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
More
Less

View Lastest Price from Ticarcillin disodium salt manufacturers

Apeloa production Co.,Limited
Product
Ticarcillin disodium salt 4697-14-7
Price
US $1.00/g
Min. Order
1g
Purity
0.98
Supply Ability
1000
Release date
2024-05-29
Shaanxi Dideu Medichem Co. Ltd
Product
Ticarcillin disodium salt 4697-14-7
Price
US $1.00-22.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100000KG
Release date
2024-08-07
Shaanxi Haibo Biotechnology Co., Ltd
Product
Ticarcillin Disodium salt 4697-14-7
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-09-04

4697-14-7, Ticarcillin disodium saltRelated Search:


  • (2S,5S,6R)-6-[[(2R)-CARBOXY-3-THIENYLACETYL]AMINO]-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3,2,0]HEPT
  • (2S,5R,6R)-6-[[(2R)-CARBOXY-3-THIENYLACETYL]AMINO]-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID DISODIUM SALT
  • TICAR
  • TICARCILLIN DISODIUM
  • Ticarcillin Sodium/Potassium Clavulanate (15:1)
  • Disodium (2S,5R,6R)-6-[[(2RS)-2-carboxylato-2-(thiophen-3-yl)acetyl] amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
  • Ticarcillin disodium salt, Antibiotic for Culture Media Use Only
  • Ticarcillin (sodium salt)
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[[2-carboxy-2-(3-thienyl)acetyl]amino]-3,3-dimethyl-7-oxo-, sodium salt(1:2), (2S,5R,6R)-
  • Timentin, ?>99.0%
  • 3-thiophenemalonamicacid,n-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicylo(3
  • ticarpen
  • TICARCILLIN IMPURITY A(2S,5R,6R)-3,3-DIMETHYL-7-OXO-6-[[(THIOPHEN-3-YL)ACETYL]-AMINO]-4-THIA-1- AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID (DECARBOXYTICARCILLIN) EPT(CRM STANDARD)
  • TicarcillinDisodiumC15H14N2Na2O6S2
  • Ticarcillin sodium
  • Timentin sodium
  • CSL Ticillin , Tarcil
  • SmithKline Beecham Sodium Ticarcillin
  • [2S-[2α,5α,6β(S^<*>^)]]-6-[(Carboxy-3-thienylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1- azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt
  • Aerugipen
  • Neoanabactyl
  • Ticalpenin
  • Ticarcillin disodium salt/Potassium clavulanate mixture (15:1)
  • Ticarcillin disodium salt,(2S,5R,6R)-6-[[(2R)-Carboxy-3-thienylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt
  • Ticillin Disodium Salt
  • TiMentin (Ticarcillin/Clavunate,15:1)
  • Ticarcillin monosodium CRS
  • Ticarcillin disodium salt USP/EP/BP
  • TimentiTimentin n
  • Ticarcillin 13C3 disodium salt
  • Ticarcillin disodium salt ≥95%
  • (2s,5r,6r)-6-[[(2r)-carboxy-3-thienylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt
  • Ticillin
  • Ticarcillin Disodium Salt extrapure, 85%, Endotoxin (BET) 0.05EU/mg
  • Ticarcillin sodium, Ticarcillin disodium salt
  • (2S,5R,6R)-6-[[2-carboxy-2-(3-thienyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt (1:2)
  • (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[[(thiophen-3-yl)acetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (decarboxyticarcillin)
  • Disodium (2S,5R,6R)-6-(2-carboxylato-2-(thiophen-3-yl)acetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
  • 4697-14-7
  • C15H14N2O6S22Na
  • C15H14N2Na2O6S2
  • C15H14N2O6S2Na2
  • Antibiotics T-Z
  • Antibiotics A to Z
  • Antibiotics
  • BioChemical
  • BAYCOX
  • antibiotic
  • 4697-14-7