Clinafloxacin hydrochloride

Product Name: Clinafloxacin hydrochloride
CAS No.: 105956-99-8
Chemical Name: Clinafloxacin hydrochloride
Synonyms: M 1091;KR 11095;ClinafoxacinHCl;CLINAFLOXACIN HCL;Clinafloxacinhydrochloride;CLINANFLOXACIN HYDROCHLORIDE;HYDROGEN CLINAFLOXACIN CHLORIDE;Clinafloxacin hydrochloride USP/EP/BP;Clinafloxacin hydrochloride (PD127391);7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid hydrochloride
CBNumber: CB3148235
Molecular Formula: C17H18Cl2FN3O3
Formula Weight: 402.25
MOL File: 105956-99-8.mol

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Clinafloxacin hydrochloride Property

Melting point:: 162-168°C
storage temp.: Refrigerator
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly, Heated)
form: Solid
color: Pale Yellow to Light Yellow
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16923
Product name: Clinafloxacin (hydrochloride)
Purity: ≥95%
Packaging: 100mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 16923
Product name: Clinafloxacin (hydrochloride)
Purity: ≥95%
Packaging: 1g
Price: $456
Updated: 2024/03/01

Cayman Chemical

Product number: 16923
Product name: Clinafloxacin (hydrochloride)
Purity: ≥95%
Packaging: 250mg
Price: $184
Updated: 2024/03/01

Cayman Chemical

Product number: 16923
Product name: Clinafloxacin (hydrochloride)
Purity: ≥95%
Packaging: 500mg
Price: $292
Updated: 2024/03/01

TRC

Product number: C579000
Product name: ClinafloxacinHydrochloride
Packaging: 500mg
Price: $340
Updated: 2021/12/16

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Clinafloxacin hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

antibacterial

Uses

A new fluoroquinolone antimicrobial agent as a potent intraphagocytic bactericidal agent for both gram-positive and gram-negative bacteria.

Biological Activity

clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both dna gyrase and topoisomerase iv dually in streptococcus pneumonia. clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections.in selected volunteer subjects and patients, after the administration of oral and intravenous doses of racemic drug, the clinafloxacin showed a broad-spectrum antibiotic of the quinolone carboxylic acid category. the absorption of the clinafloxacin enantiomer was rapid after oral 400 mg dose and 400 mg intravenous dose of racemic drug [1]. clinafloxacin showed high activity against s. pneumoniae 7785 with the mic value of 0.125 μg/ml. clinafloxacin showed potent broad-spectrum in vitro activity against gram-positive, gram-negative, and anaerobic pathogens [2]. clinafloxacin has been identified as the most active fluoroquinolone against s. pneumoniae compared to grepafloxacin, levofloxacin, ofloxacin, sparfloxacin, and trovafloxacin and is currently being evaluated as an antipneumococcal agent [3].

References

[1]. humphrey g h, shapiro m a, randinitis e j, et al. pharmacokinetics of clinafloxacin enantiomers in humans[j]. the journal of clinical pharmacology, 1999, 39(11): 1143-1150.
[2]. pan x s, fisher l m. dna gyrase and topoisomerase iv are dual targets of clinafloxacin action in streptococcus pneumoniae[j]. antimicrobial agents and chemotherapy, 1998, 42(11): 2810-2816.
[3]. jorgensen j h, weigel l m, swenson j m, et al. activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant streptococcus pneumoniae[j]. antimicrobial agents and chemotherapy, 2000, 44(11): 2962-2968.

Clinafloxacin hydrochloride Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from Clinafloxacin hydrochloride manufacturers

Dideu Industries Group Limited

Product: Clinafloxacin hydrochloride 105956-99-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-19

Career Henan Chemical Co

Product: Clinafloxacin hydrochloride 105956-99-8
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100KG
Release date: 2018-08-20

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CLINAFLOXACIN HCL

CLINANFLOXACIN HYDROCHLORIDE

Clinafloxacinhydrochloride

7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride

7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-keto-quinoline-3-carboxylic acid hydrochloride

7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid hydrochloride

7-(3-azanylpyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-quinoline-3-carboxylic acid hydrochloride

7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride

3-Quinolinecarboxylic acid, 7-(3-aMino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, Monohydrochloride (9CI)

KR 11095

M 1091

ClinafoxacinHCl

HYDROGEN CLINAFLOXACIN CHLORIDE

Clinafloxacin hydrochloride USP/EP/BP

Clinafloxacin hydrochloride (PD127391)

3-Quinolinecarboxylic acid, 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, hydrochloride (1:1)

7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-Quinolinecarboxylic acid hydrochloride (1:1)

105956-99-8

C17H17ClFN3O3HCl

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