2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE
- Product Name
- 2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE
- CAS No.
- 17874-76-9
- Chemical Name
- 2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE
- Synonyms
- 6-(METHOXYCARBONYL)NICOTINIC ACID;6-Methoxycarbonylpyridine-3-carboxylicaci;(Methoxycarbonyl)pyridine-3-carboxylic acid;2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE;2-Methylhydrogenpyridin-2,5-dicarboxylic acid;2,5-Pyridinedicarboxylic acid, 2-methyl ester;6-(Methoxycarbonyl)pyridine-3-carboxylic acid;5-Carboxy-2-(methoxycarbonyl)pyridine, 6-(Methoxycarbonyl)pyridine-3-carboxylic acid
- CBNumber
- CB31486826
- Molecular Formula
- C8H7NO4
- Formula Weight
- 181.15
- MOL File
- 17874-76-9.mol
2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE Property
- Melting point:
- 161.5 °C(Solv: methanol (67-56-1))
- Boiling point:
- 383.8±27.0 °C(Predicted)
- Density
- 1.361±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Solid
- pka
- 3.04±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M330708
- Product name
- 6-(Methoxycarbonyl)nicotinicAcid
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- OR300619
- Product name
- 6-(Methoxycarbonyl)nicotinicacid
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- V3866
- Product name
- 2-Methylhydrogenpyridine-2,5-dicarboxylate
- Packaging
- 1g
- Price
- $184
- Updated
- 2021/12/16
- Product number
- 083396
- Product name
- 6-(Methoxycarbonyl)nicotinic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $247
- Updated
- 2021/12/16
- Product number
- OR300619
- Product name
- 6-(Methoxycarbonyl)nicotinicacid
- Packaging
- 5g
- Price
- $290
- Updated
- 2021/12/16
2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE Chemical Properties,Usage,Production
Synthesis
67-56-1
100-26-5
17874-76-9
The general procedure for the synthesis of 6-(methoxycarbonyl)nicotinic acid from methanol and 2,5-dipyridinecarboxylic acid is as follows: with reference to the literature method 66, a selective esterification reaction was first carried out on 2,5-pyridinedicarboxylic acid (58). 58 was dissolved in methanol, a catalytic amount of sulfuric acid was added and the reaction was refluxed for 2 hours. Upon completion of the reaction, the monomethyl ester product (59) was purified by recrystallization from water in 42% yield. Subsequently, the monomethyl ester 59 was converted to the corresponding acyl chloride (60) by reflux reaction with an excess of thionyl chloride. Finally, the acylation of compound 35 was completed using the reflux reaction of the chloride 60 with an excess of aluminum trichloride in dichloromethane (DCM) (Scheme 10).
References
[1] Patent: WO2011/103321, 2011, A1. Location in patent: Page/Page column 23
[2] Patent: US2006/293319, 2006, A1. Location in patent: Page/Page column 47
[3] Patent: WO2007/70173, 2007, A2. Location in patent: Page/Page column 145-146
[4] European Journal of Inorganic Chemistry, 2010, # 13, p. 1913 - 1928
[5] Patent: WO2012/121973, 2012, A1. Location in patent: Page/Page column 89
2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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