ChemicalBook > CAS DataBase List > 2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE

2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE

Product Name
2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE
CAS No.
17874-76-9
Chemical Name
2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE
Synonyms
6-(METHOXYCARBONYL)NICOTINIC ACID;6-Methoxycarbonylpyridine-3-carboxylicaci;(Methoxycarbonyl)pyridine-3-carboxylic acid;2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE;2-Methylhydrogenpyridin-2,5-dicarboxylic acid;2,5-Pyridinedicarboxylic acid, 2-methyl ester;6-(Methoxycarbonyl)pyridine-3-carboxylic acid;5-Carboxy-2-(methoxycarbonyl)pyridine, 6-(Methoxycarbonyl)pyridine-3-carboxylic acid
CBNumber
CB31486826
Molecular Formula
C8H7NO4
Formula Weight
181.15
MOL File
17874-76-9.mol
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2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE Property

Melting point:
161.5 °C(Solv: methanol (67-56-1))
Boiling point:
383.8±27.0 °C(Predicted)
Density 
1.361±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
form 
Solid
pka
3.04±0.10(Predicted)
Appearance
White to off-white Solid
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M330708
Product name
6-(Methoxycarbonyl)nicotinicAcid
Packaging
500mg
Price
$200
Updated
2021/12/16
Matrix Scientific
Product number
083396
Product name
6-(Methoxycarbonyl)nicotinic acid
Purity
97%
Packaging
1g
Price
$247
Updated
2021/12/16
AK Scientific
Product number
V3866
Product name
2-Methylhydrogenpyridine-2,5-dicarboxylate
Packaging
5g
Price
$451
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0097620
Product name
6-(METHOXYCARBONYL)NICOTINIC ACID
Purity
95.00%
Packaging
1G
Price
$721.57
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0097620
Product name
6-(METHOXYCARBONYL)NICOTINIC ACID
Purity
95.00%
Packaging
2.5G
Price
$983.88
Updated
2021/12/16
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2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE Chemical Properties,Usage,Production

Synthesis

67-56-1

100-26-5

17874-76-9

The general procedure for the synthesis of 6-(methoxycarbonyl)nicotinic acid from methanol and 2,5-dipyridinecarboxylic acid is as follows: with reference to the literature method 66, a selective esterification reaction was first carried out on 2,5-pyridinedicarboxylic acid (58). 58 was dissolved in methanol, a catalytic amount of sulfuric acid was added and the reaction was refluxed for 2 hours. Upon completion of the reaction, the monomethyl ester product (59) was purified by recrystallization from water in 42% yield. Subsequently, the monomethyl ester 59 was converted to the corresponding acyl chloride (60) by reflux reaction with an excess of thionyl chloride. Finally, the acylation of compound 35 was completed using the reflux reaction of the chloride 60 with an excess of aluminum trichloride in dichloromethane (DCM) (Scheme 10).

References

[1] Patent: WO2011/103321, 2011, A1. Location in patent: Page/Page column 23
[2] Patent: US2006/293319, 2006, A1. Location in patent: Page/Page column 47
[3] Patent: WO2007/70173, 2007, A2. Location in patent: Page/Page column 145-146
[4] European Journal of Inorganic Chemistry, 2010, # 13, p. 1913 - 1928
[5] Patent: WO2012/121973, 2012, A1. Location in patent: Page/Page column 89

2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE Suppliers

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17874-76-9, 2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATERelated Search:

Quinolinic acid 2,5-PYRIDINEDICARBOXYLIC ACID DI-N-PROPYL ESTER 6-(Ethoxycarbonyl)nicotinic acid DIMETHYL 3-AMINOPYRIDINE-2,5-DICARBOXYLATE 2,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER 2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE 2,5-PYRIDINEDICARBOXYLIC ACID, 6-METHYL-, 2,5-DIETHYL ESTER DIMETHYL PYRIDINE-2,5-DICARBOXYLATE

  • 2-METHYL HYDROGEN PYRIDINE-2,5-DICARBOXYLATE
  • 6-(METHOXYCARBONYL)NICOTINIC ACID
  • (Methoxycarbonyl)pyridine-3-carboxylic acid
  • 5-Carboxy-2-(methoxycarbonyl)pyridine, 6-(Methoxycarbonyl)pyridine-3-carboxylic acid
  • 6-(Methoxycarbonyl)pyridine-3-carboxylic acid
  • 2,5-Pyridinedicarboxylic acid, 2-methyl ester
  • 6-Methoxycarbonylpyridine-3-carboxylicaci
  • 2-Methylhydrogenpyridin-2,5-dicarboxylic acid
  • 17874-76-9
  • Esters
  • Pyridines