ChemicalBook > CAS DataBase List > 6-CHLORO-1,2,3,4-TETRAHYDROQUINOLINE

6-CHLORO-1,2,3,4-TETRAHYDROQUINOLINE

Product Name
6-CHLORO-1,2,3,4-TETRAHYDROQUINOLINE
CAS No.
49716-18-9
Chemical Name
6-CHLORO-1,2,3,4-TETRAHYDROQUINOLINE
Synonyms
6-CHLORO-1,2,3,4-TETRAHYDROQUINOLINE;Quinoline, 6-chloro-1,2,3,4-tetrahydro-
CBNumber
CB31497987
Molecular Formula
C9H10ClN
Formula Weight
167.64
MOL File
49716-18-9.mol
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6-CHLORO-1,2,3,4-TETRAHYDROQUINOLINE Property

Melting point:
41 °C
Boiling point:
125-127 °C(Press: 3 Torr)
Density 
1.162±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
4.43±0.20(Predicted)
Appearance
Light brown to brown Solid
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Safety

HazardClass 
IRRITANT
HS Code 
2933499090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
C428783
Product name
6-Chloro-1,2,3,4-tetrahydroquinoline
Packaging
250mg
Price
$125
Updated
2021/12/16
Matrix Scientific
Product number
058217
Product name
6-Chloro-1,2,3,4-tetrahydroquinoline
Purity
>95%
Packaging
1g
Price
$139
Updated
2021/12/16
Ark Pharm
Product number
P000213479
Product name
6-Chloro-1,2,3,4-tetrahydroquinoline
Purity
95+%
Packaging
100mg
Price
$48
Updated
2021/12/16
Ark Pharm
Product number
P000213479
Product name
6-Chloro-1,2,3,4-tetrahydroquinoline
Purity
95+%
Packaging
250mg
Price
$73
Updated
2021/12/16
Matrix Scientific
Product number
058217
Product name
6-Chloro-1,2,3,4-tetrahydroquinoline
Purity
>95%
Packaging
500mg
Price
$91
Updated
2021/12/16
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6-CHLORO-1,2,3,4-TETRAHYDROQUINOLINE Chemical Properties,Usage,Production

Uses

6-Chloro-1,2,3,4-tetrahydroquinoline (cas# 49716-18-9) is a compound useful in organic synthesis.

Synthesis Reference(s)

Tetrahedron Letters, 28, p. 77, 1987 DOI: 10.1016/S0040-4039(00)95653-3

Synthesis

612-57-7

49716-18-9

GENERAL STEPS: PdNPore (2.7 mg, 5 mol%) was dissolved in acetonitrile (5 mL) and 6-chloroquinoline (81.8 mg, 0.5 mmol) was added. The reaction mixture was placed in a magnetic stirrer at 30 °C for 16 h under hydrogen atmosphere (5 bar). After completion of the reaction, it was purified by column chromatography (silica gel, 200-300 mesh, ethyl acetate as eluent) to afford 6-chloro-1,2,3,4-tetrahydroquinoline (69.57 mg, 83% yield).

References

[1] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 17, p. 7956 - 7967
[2] Angewandte Chemie - International Edition, 2016, vol. 55, # 50, p. 15656 - 15661
[3] Angew. Chem., 2016, vol. 128, # 50, p. 15885 - 15890,6
[4] Organic Letters, 2013, vol. 15, # 7, p. 1484 - 1487
[5] Chemical Communications, 2013, vol. 49, # 63, p. 7052 - 7054

6-CHLORO-1,2,3,4-TETRAHYDROQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-CHLORO-1,2,3,4-TETRAHYDROQUINOLINE Suppliers

China 89 India 1 Ukraine 1 United States 5 Global 96
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
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Shijiazhuang Lickon PharmaTech Co., Ltd.
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Bide Pharmatech Ltd.
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49716-18-9, 6-CHLORO-1,2,3,4-TETRAHYDROQUINOLINERelated Search:

7-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE 8-chloro-1,2,3,4-tetrahydroquinoline 8-Methyl-1,2,3,4-tetrahydroquinoline 7-Fluoro-1,2,3,4-tetrahydroquinoline 6-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE 7-Methoxy-1,2,3,4-tetrahydroquinoline 8-METHOXY-1,2,3,4-TETRAHYDROQUINOLINE 6-Isopropyl-1,2,3,4-tetrahydroquinoline 6-(tert-butyl)-1,2,3,4-tetrahydroquinoline 6-Chloro-1,2,3,4-tetrahydroisoquinoline 7-Chloro-1,2,3,4-tetrahydroquinoline 8-bromo-1,2,3,4-tetrahydroquinoline 6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE 7-BroMo-2,3-dihydroquinolin-4(1H)-one 8-FLUORO-1,2,3,4-TETRAHYDROQUINOLINE 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE 6-CHLORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE 6,7-dichloro-1,2,3,4-tetrahydroquinoline

  • 6-CHLORO-1,2,3,4-TETRAHYDROQUINOLINE
  • Quinoline, 6-chloro-1,2,3,4-tetrahydro-
  • 49716-18-9