2,4-Dichloro-8-methoxyquinazoline

Product Name: 2,4-Dichloro-8-methoxyquinazoline
CAS No.: 61948-60-5
Chemical Name: 2,4-Dichloro-8-methoxyquinazoline
Synonyms: 2,4-Dichloro-8-methoxyquizoline;2,4-Dichloro-8-methoxyquinazoline;8-Methoxy-2,4-dichloroquinazoline;Quinazoline, 2,4-dichloro-8-methoxy-
CBNumber: CB31504498
Molecular Formula: C9H6Cl2N2O
Formula Weight: 229.06
MOL File: 61948-60-5.mol

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2,4-Dichloro-8-methoxyquinazoline Property

Melting point:: 157-159 °C
Boiling point:: 315.9±24.0 °C(Predicted)
Density: 1.450
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -0.84±0.30(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D434290
Product name: 2,4-Dichloro-8-methoxyquinazoline
Packaging: 1g
Price: $275
Updated: 2021/12/16

TRC

Product number: D434290
Product name: 2,4-Dichloro-8-methoxyquinazoline
Packaging: 500mg
Price: $165
Updated: 2021/12/16

AK Scientific

Product number: W7401
Product name: 2,4-Dichloro-8-methoxyquinazoline
Packaging: 5g
Price: $837
Updated: 2021/12/16

AK Scientific

Product number: W7401
Product name: 2,4-Dichloro-8-methoxyquinazoline
Packaging: 250mg
Price: $126
Updated: 2021/12/16

Ambeed

Product number: A218658
Product name: 2,4-Dichloro-8-methoxyquinazoline
Purity: 97%
Packaging: 1g
Price: $152
Updated: 2021/12/16

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2,4-Dichloro-8-methoxyquinazoline Chemical Properties,Usage,Production

Chemical Properties

White flocculent solid

Uses

2,4-Dichloro-8-methoxyquinazoline has been used as a reactant for the preparation of p97 ATPase inhibitors.

Synthesis

62484-14-4

61948-60-5

General procedure for the synthesis of 2,4-dichloro-8-methoxyquinazoline from 8-methoxyquinazoline-2,4(1H,3H)-dione: 8-methoxyquinazoline-2,4-diol (5.5 g, 28.6 mmol) prepared in step 1 was mixed with phosphorochloridic acid chloride (25 ml) and the reaction was stirred under reflux conditions overnight. After completion of the reaction, the mixture was cooled to room temperature, slowly poured into ice water and the pH was adjusted to 7-8 with sodium hydroxide solution.Subsequently, the aqueous layer was extracted with dichloromethane, the organic layers were combined and dried with anhydrous magnesium sulfate. After the solvent was removed by concentration under reduced pressure, the residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=5/1) to afford the target product 2,4-dichloro-8-methoxyquinazoline (2.1 g) as a white solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.83 (d, 1H), 7.65 (t, 1H), 7.34 (d, 1H), 4.09 (s, 3H).

References

[1] Patent: WO2016/200840, 2016, A1. Location in patent: Page/Page column 433
[2] Patent: WO2014/101113, 2014, A1. Location in patent: Paragraph 0165
[3] Patent: WO2014/101120, 2014, A1. Location in patent: Paragraph 0124
[4] Patent: WO2014/105666, 2014, A1. Location in patent: Paragraph 0116
[5] Patent: WO2014/101373, 2014, A1. Location in patent: Page/Page column 43; 44

2,4-Dichloro-8-methoxyquinazoline Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-Dichloro-8-methoxyquinazoline Suppliers

China 103 Germany 2 India 1 United States 9 Global 115

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View Lastest Price from 2,4-Dichloro-8-methoxyquinazoline manufacturers

Career Henan Chemical Co

Product: 2,4-Dichloro-8-methoxyquinazoline 61948-60-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-30

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2,4-Dichloro-8-methoxyquinazoline

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8-Methoxy-2,4-dichloroquinazoline

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61948-60-5

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