ChemicalBook > CAS DataBase List > Ammothamnine

Ammothamnine

Product Name
Ammothamnine
CAS No.
16837-52-8
Chemical Name
Ammothamnine
Synonyms
OXYMATRINE;Kurainone;cis-matrine;ammothamnine;MATRINE OXIDE;OXYMATRINE(P);Oxymatrine-RM;Oxymatrine,(S);Pachycarpidine;Oxymatrine CRS
CBNumber
CB3150469
Molecular Formula
C15H24N2O2
Formula Weight
264.36
MOL File
16837-52-8.mol
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Ammothamnine Property

Melting point:
208℃
storage temp. 
Inert atmosphere,2-8°C
solubility 
methanol: soluble10mg/mL, clear, colorless
pka
4.87±0.20(Predicted)
form 
powder
color 
white to off-white
Stability:
Hygroscopic
InChI
InChI=1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15?,17+/m0/s1
InChIKey
XVPBINOPNYFXID-LHDUFFHYSA-N
SMILES
[N@@+]12([O-])CCC[C@]3([H])C1[C@@]([H])([C@@]1([H])CCCC(=O)N1C3)CCC2
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Safety

Hazard Codes 
Xn
Risk Statements 
22-20/22
Safety Statements 
24/25
WGK Germany 
3
RTECS 
OQ1770000
HS Code 
29399990
Hazardous Substances Data
16837-52-8(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0002015
Product name
Oxymatrine
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
15 mg
Price
$155
Updated
2025/07/31
Sigma-Aldrich
Product number
PHL89748
Product name
Oxymatrine
Purity
phyproof? Reference Substance
Packaging
25MG
Price
$305
Updated
2025/07/31
Sigma-Aldrich
Product number
Y0002015
Product name
Oxymatrine
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
Y0002015
Price
$150
Updated
2023/06/20
TCI Chemical
Product number
O0465
Product name
Oxymatrine
Packaging
5G
Price
$57
Updated
2025/07/31
Cayman Chemical
Product number
14915
Product name
Oxymatrine
Purity
≥98%
Packaging
50mg
Price
$49
Updated
2024/03/01
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Ammothamnine Chemical Properties,Usage,Production

Description

An alkaloid from Sophora angustifolia var. flavescens S. and Z., the bas'e crystal_x0002_lizes as the monohydrate having the lower melting point given above. It is dextrorotatory with [α]19D + 47.7° (EtOH) and yields crystalline salts and derivatives: hydrobromide, m.p. 21SoC; aurichloride, m.p. 207°C (dec.); perchlorate, m.p. 240°C (dec.); picrate, m.p. 21SoC and the methochloride aurichloride, m.p. 18SoC (dec.). Ochiai and Ito have shown that it is formed by the action of hydrogen peroxide on Matrine (q.v.), indicating that its structure is matrine-N-oxide.

Description

Oxymatrine is a natural alkaloid isolated from the root of S. flavescens, an herb used in traditional Chinese herbal medicine. It has antiviral properties, inhibiting the replication of hepatitis B alone and in combination with lamivudine. Oxymatrine also prevents fibrosis in a number of organs including liver, at least in part by interfering with TGF-β signaling. This compound also induces apoptosis in certain cancer cells and ameliorates inflammation by impairing the translocation of nuclear factors-κB.

Chemical Properties

Colorless lumpy crystals, easily soluble in chloroform, methanol, insoluble in petroleum ether, acetone, derived from Yam bean root, bitter ginseng.

Uses

Oxymatrine is a an anti-tumor agent triggering apoptosis in human leukemia cells.

Uses

antifungal, hepatoprotectant

Definition

ChEBI: Ammothamnine is an alkaloid and a tertiary amine oxide.

References

Kondo et al., Arch. Pharm., 275,493 (1937)
Ochiai, Ito., Ber., 81,938 (1938)

Ammothamnine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ammothamnine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Ammothamnine(Oxymatrine) 16837-52-8
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20T
Release date
2025-08-30
Hebei Chuanghai Biotechnology Co., Ltd
Product
Ammothamnine 16837-52-8
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-29
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Oxymatrine 16837-52-8
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-24

16837-52-8, AmmothamnineRelated Search:

Iron oxide NITRIC OXIDE Zinc oxide Magnesium oxide SophoraAlkaloidsTannate Propylene oxide Matrine ETHYLENE OXIDE 13,14-Didehydromatridin-15-one Oxyresveratrol oxypaeoniflora OXYPEUCEDANIN Oxyepiberberine oxysophoridine OXYSOPHOCARPINE (Diethoxymethyl)diphenylphosphine oxide Rotundine Quercetin dihydrate

  • OXYMATRINE
  • 1-oxide,(1-beta)-matridin-15-on
  • 1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, dodecahydro-, 4-oxide, (4R,7aS,13aR,13bR,13cS)-
  • Ammothamnine Oxymatrine
  • Oxymatrine, 98%, from Sophora flavescens Aiton
  • (4R,7aS,13aR,13bR,13cS)-dodecahydro-4-oxide-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one
  • Oxymatrine 16837-52-8
  • matrine,1-oxide
  • matrine1beta-oxide
  • ammothamnine
  • (6AS,11AR,11BR,11CS)-3A-OXY-DODECAHYDRO-3A,7A-DIAZA-BENZO[DE]ANTHRACEN-8-ONE
  • matrine n-oxide
  • MATRINE OXIDE
  • Kurainone
  • OXYMATRINE, 98.0% BY HPLC
  • Oxymatrine std.
  • OXYMATRINE(P)
  • Matridin-15-one,1-oxide, (1β)-
  • Oxymatrine，Matrine N-oxide，Ammothamnine
  • Matrine N-oxide. Ammothamnine. Pachycarpidine
  • Oxymatrine,(S)
  • Dodecahydro-1,8-dihydroxy-7,14-methano-4H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocin-4-one
  • OxyMatrine(Matrine N-oxide)
  • Pachycarpidine
  • cis-matrine
  • Oxymatrine CRS
  • Oxymatrine Standard
  • Ammothamnine USP/EP/BP
  • (1R,2R,9S,13S,17S)-13-Oxido-7-aza-13-azoniatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one
  • (4S,41S,7aS,13aR,13bR)-10-Oxododecahydro-1H,5H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridine 4(41H)-oxide
  • oxymatrine?pesticide
  • Oxymatrine Marine
  • Oxysophoridine|||Matrine N-oxide
  • Oxymatrine 100 μg/ml Acetonitrile
  • Oxymatrine-RM
  • Oxymatrine in Acetonitrile
  • Oxymatrine, 10 mM in DMSO
  • Oxymatrine Min 98%
  • (+)-Oxymatrine
  • 16837-52-8
  • 6837-52-8
  • C15H24N2O2
  • Pyrazoles
  • Inhibitors
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Plant extracts
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • Plant extract
  • Alkaloids
  • Natural Plant Extract
  • Pharmaceutical material and intermeidates
  • 16837-52-8