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METHYL 1H-PYRAZOLE-4-CARBOXYLATE

Product Name
METHYL 1H-PYRAZOLE-4-CARBOXYLATE
CAS No.
51105-90-9
Chemical Name
METHYL 1H-PYRAZOLE-4-CARBOXYLATE
Synonyms
Methyl 4-pyrazolecarboxylate;Pyrazole-4-methyl carboxylate;Methyl pyrazole-4-carboxylate;Methyl4-1H-pyrazolecarboxylate;4-(Methoxycarbonyl)-1H-pyrazole;Methyl 1H-pyrazol-4-carboxylate;METHYL 1H-PYRAZOLE-4-CARBOXYLATE;Methyl 1H-pyrazole-4-carboxylate 97%;PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER;1H-Pyrazol-4-carboxylic acid methyl ester
CBNumber
CB3151097
Molecular Formula
C5H6N2O2
Formula Weight
126.11
MOL File
51105-90-9.mol
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METHYL 1H-PYRAZOLE-4-CARBOXYLATE Property

Melting point:
145-146℃
Boiling point:
271℃
Density 
1.275
Flash point:
118℃
storage temp. 
Inert atmosphere,Room Temperature
form 
solid
pka
11.59±0.50(Predicted)
color 
Faint yellow
InChI
InChI=1S/C5H6N2O2/c1-9-5(8)4-2-6-7-3-4/h2-3H,1H3,(H,6,7)
InChIKey
VFTZKSMAJVLWOV-UHFFFAOYSA-N
SMILES
N1C=C(C(OC)=O)C=N1
CAS DataBase Reference
51105-90-9
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Safety

HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M328290
Product name
Methyl1H-Pyrazole-4-carboxylate
Packaging
1g
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
OR30826
Product name
Methyl1H-pyrazole-4-carboxylate
Purity
97%
Packaging
250mg
Price
$15
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-1-70
Product name
Methyl 1H-pyrazole-4-carboxylate
Packaging
250mg
Price
$16
Updated
2021/12/16
Apolloscientific
Product number
OR30826
Product name
Methyl1H-pyrazole-4-carboxylate
Purity
97%
Packaging
1g
Price
$28
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-1-70
Product name
Methyl 1H-pyrazole-4-carboxylate
Packaging
1g
Price
$31
Updated
2021/12/16
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METHYL 1H-PYRAZOLE-4-CARBOXYLATE Chemical Properties,Usage,Production

Uses

Methyl 1H-Pyrazole-4-carboxylate is used to prepare aminomethylpiperidines as β3-agonists. It is also a possbile inhibitor of liver alcohol dehydrogenase.

Synthesis

67-56-1

37718-11-9

51105-90-9

A) Synthesis of methyl 1H-pyrazole-4-carboxylate: 1H-pyrazole-4-carboxylic acid (4.00 g) was dissolved in 4M HCl/methanol solution (150 mL) and the reaction was stirred overnight at room temperature. After completion of the reaction, the solvent was removed by rotary evaporation at room temperature. The product was dried under reduced pressure to give the title compound 1H-pyrazole-4-carboxylic acid methyl ester (5.0 g, white solid). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 3.72 (3H, s, -OCH3), 8.09 (2H, s, pyrazole ring-H), 11.62 (1H, s, -NH).

References

[1] Patent: WO2017/68089, 2017, A2. Location in patent: Page/Page column 297; 298
[2] Patent: EP2848618, 2015, A1. Location in patent: Paragraph 0842
[3] Patent: WO2018/31877, 2018, A1. Location in patent: Paragraph 00194

METHYL 1H-PYRAZOLE-4-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 1H-PYRAZOLE-4-CARBOXYLATE Suppliers

China 96 India 3 United Kingdom 4 United States 10 Global 113
Nanjing Chemcn Pharmaceutical Co., Ltd.
Tel
18114022054; 18114022054
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+86-25-58857385
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3317707757@qq.com
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China
ProdList
301
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55
Dalian lichuang Chemical Co., Ltd
Tel
0411-0411-00000000 13644282108
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3500508746@qq.com
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China
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2896
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55
PharmaBlock Sciences (Nanjing),Inc.
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025-86918202 4000255188
Fax
86-025-86918232
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sales@pharmablock.com
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China
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5000
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55
Energy Chemical
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021-021-58432009 400-005-6266
Fax
021-58436166
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sales8178@energy-chemical.com
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China
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Beijing Ouhe Technology Co., Ltd
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010-010-82967028 13522913783
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+86-10-82967029
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2355560935@qq.com
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China
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12000
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956
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0573-85285100
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isenchem@163.com
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China
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66
Adamas Reagent, Ltd.
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400-6009262 16621234537
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021-64823266
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chenyj@titansci.com
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China
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Accela ChemBio Co.,Ltd.
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021-50795510 4000665055
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021-50795055
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sales@accelachem.com
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China
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11035
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64
Nanjing Chemlin Chemical Co., Ltd
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025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
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China
ProdList
15883
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64
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
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66
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View Lastest Price from METHYL 1H-PYRAZOLE-4-CARBOXYLATE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
METHYL 1H-PYRAZOLE-4-CARBOXYLATE 51105-90-9
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-24
Shaanxi Dideu Medichem Co. Ltd
Product
Methyl 1H-pyrazole-4-carboxylate 51105-90-9
Price
US $1.00-1.00/KG
Min. Order
1KG
Purity
99%+
Supply Ability
100 tons
Release date
2019-12-26
Shaanxi Dideu Medichem Co. Ltd
Product
Methyl 1H-pyrazole-4-carboxylate 51105-90-9
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%+
Supply Ability
100 tons
Release date
2020-01-15

51105-90-9, METHYL 1H-PYRAZOLE-4-CARBOXYLATERelated Search:

3,5-PYRAZOLEDICARBOXYLIC ACID MONOHYDRATE Pyrazole-3-carboxamide ETHYL 5-AMINO-1-METHYLPYRAZOLE-4-CARBOXYLATE 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE ETHYL 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 2-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE ETHYL 3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE Ethyl pyrazole-4-carboxylate 5-AMINO-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER ETHYL 1-METHYL-5-(1H-PYRROL-1-YL)-1H-PYRAZOLE-4-CARBOXYLATE PYRAZOLE-4-CARBOXYLIC ACID, 3-AMINO-1-METHYL-, ETHYL ESTER METHYL 5-METHYL-1-PHENYLPYRAZOLE-4-CARBOXYLATE ETHYL 1-(4-CHLOROPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 1-(2,4-DIFLUOROPHENYL)-5-METHYLPYRAZOLE-4-CARBOXYLATE METHYL 5-ISOXAZOL-5-YL-3-METHYL-1H-PYRAZOLE-4-CARBOXYLATE METHYL 3-METHYL-5-(5-METHYLISOXAZOL-3-YL)-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 1-(2,3,3-TRICHLOROACRYLOYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE ETHYL 1-(6-CHLOROPYRIDAZIN-3-YL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLATE

  • PYRAZOLE-4-CARBOXYLIC ACID METHYL ESTER
  • Methyl4-1H-pyrazolecarboxylate
  • Methyl 4-pyrazolecarboxylate
  • METHYL 1H-PYRAZOLE-4-CARBOXYLATE
  • Methyl pyrazole-4-carboxylate
  • 1H-Pyrazole-4-carboxylic acid methyl ester
  • 4-(Methoxycarbonyl)-1H-pyrazole
  • Methyl 1H-pyrazole-4-carboxylate 97%
  • 1H-Pyrazole-4-carboxylic acid, methyl ester (9CI, ACI)
  • 1H-Pyrazol-4-carboxylic acid methyl ester
  • Pyrazole-4-methyl carboxylate
  • Methyl 1H-pyrazol-4-carboxylate
  • 51105-90-9