4-Iodo-2-methoxypyridine-3-carboxaldehyde

Product Name: 4-Iodo-2-methoxypyridine-3-carboxaldehyde
CAS No.: 158669-26-2
Chemical Name: 4-Iodo-2-methoxypyridine-3-carboxaldehyde
Synonyms: 4-IODO-2-METHOXYNICOTINALDEHYDE;4-iodo-2-methoxypyridine-3-carbaldehyde;4-Iodo-2-Methoxypyridine-3-carboaldehyde;4-iodo-2-methoxypyridine-3-carboxadehyde;4-IODO-2-METHOXYPYRIDINE-3-CARBOXALDEHYDE;4-Iodo-2-methoxy-3-pyridinecarboxaldehyde;2-Methoxy-4-iodo-3-pyridinecarboxyaldehyde;4-Iodo-2-methoxypyridine-3-carboxyaldehyde;3-Pyridinecarboxaldehyde, 4-iodo-2-methoxy-;4-Iodo-2-methoxypyridine-3-carboxaldehyde,95%
CBNumber: CB3153824
Molecular Formula: C7H6INO2
Formula Weight: 263.03
MOL File: 158669-26-2.mol

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4-Iodo-2-methoxypyridine-3-carboxaldehyde Property

Boiling point:: 328.3±42.0 °C(Predicted)
Density: 1.873±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 0.21±0.18(Predicted)
form: Solid
Appearance: Light yellow to yellow Solid
Sensitive: Light Sensitive
InChI: InChI=1S/C7H6INO2/c1-11-7-5(4-10)6(8)2-3-9-7/h2-4H,1H3
InChIKey: GNBKAOHTTIVAMT-UHFFFAOYSA-N
SMILES: C1(OC)=NC=CC(I)=C1C=O
CAS DataBase Reference: 158669-26-2(CAS DataBase Reference)

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: I708570
Product name: 4-Iodo-2-methoxy-3-pyridinecarboxaldehyde
Packaging: 1g
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: N228
Product name: 4-Iodo-2-methoxypyridine-3-carboxaldehyde
Packaging: 1g
Price: $67
Updated: 2021/12/16

Matrix Scientific

Product number: 054277
Product name: 4-Iodo-2-methoxynicotinaldehyde
Purity: 95+%
Packaging: 1g
Price: $80
Updated: 2021/12/16

Matrix Scientific

Product number: 054277
Product name: 4-Iodo-2-methoxynicotinaldehyde
Purity: 95+%
Packaging: 5g
Price: $240
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H15-H-04
Product name: 4-Iodo-2-methoxynicotinaldehyde
Packaging: 1g
Price: $141
Updated: 2021/12/16

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4-Iodo-2-methoxypyridine-3-carboxaldehyde Chemical Properties,Usage,Production

Uses

This compound is used in the synthesis of insulin-like growth factor 1-receptor inhibitors that display anti-tumor activity.

Uses

4-Iodo-2-methoxypyridine-3-carboxaldehyde is used in the synthesis of insulin-like growth factor 1-receptor inhibitors that display anti-tumor activity.

Synthesis

916851-24-6

158669-26-2

General procedure for the synthesis of 4-iodo-2-methoxypyridine-3-carboxaldehyde (DeTMS-PM): tert-butyl lithium (1.5 M in n-pentane, 6.9 mL, 9.16 x 1.1 mmol) was added slowly and dropwise to a solution of 2-methoxypyridine (1.00 g, 9.16 mmol) in dry THF (7.5 mL) at -75 °C to -60 °C and stirred at the same temperature for 1 hour. Subsequently, a solution of anhydrous THF (10 mL) of FEO (1.44 g, 9.16 x 1.2 mmol) was added dropwise at the same temperature and stirring was continued for 30 min. The temperature of the reaction system was raised to about -23 °C, ethylene glycol dimethyl ether (DME, organic synthesis grade, 7.5 mL) was added, followed by dropwise addition of n-butyllithium (1.6 M in hexane, 9.9 mL, 9.16 x 1.7 mmol), and the reaction was maintained between -15 °C and -25 °C and stirred for 2 hours at about -23 °C. The mixture was cooled to about -70 °C, a solution of iodine (4.42 g, 9.16 x 1.9 mmol) in DME (10 mL) was added quickly and stirred at about -70 °C for 30 minutes. After warming to room temperature, 10% Na2SO3 solution (in appropriate amount until the color of iodine disappeared) was added and stirred for 10 min, followed by extraction with water, brine and ethyl acetate (50 mL). The organic layer was separated, dried with Na2SO4, filtered and concentrated to dryness. The residue (brown solid) was dissolved in chloroform and purified by medium-pressure silica gel column chromatography (n-hexane: ethyl acetate = 1000:1 → 100:1). The desired grades were collected and concentrated to dryness to give DeTMS-PM (1.31 g, 4.98 mmol, 54%) as a yellow solid. The product was confirmed by 1H-NMR (400 MHz, CDCl3): δ 4.05 (3H, s, MeO), 7.54 (1H, d, J = 5.4 Hz, Aromatic-H), 7.85 (1H, d, J = 5.4 Hz, Aromatic-H), 10.21 (1H, s, CHO).IR (KBr) showed characteristic absorption peaks (cm-1): 2943, 1697 (CHO), 1543, 1458, 1362, 1015.EI-MS (m/z): 263 [M]+ (100%).

References

[1] Patent: EP1900740, 2008, A1. Location in patent: Page/Page column 14-15

4-Iodo-2-methoxypyridine-3-carboxaldehyde Preparation Products And Raw materials

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View Lastest Price from 4-Iodo-2-methoxypyridine-3-carboxaldehyde manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 4-Iodo-2-methoxypyridine-3-carboxaldehyde 158669-26-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Dideu Industries Group Limited

Product: 4-Iodo-2-methoxypyridine-3-carboxaldehyde 158669-26-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-26

Career Henan Chemical Co

Product: 4-Iodo-2-methoxypyridine-3-carboxaldehyde 158669-26-2
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: Customized
Release date: 2018-12-14

158669-26-2, 4-Iodo-2-methoxypyridine-3-carboxaldehydeRelated Search:

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4-Iodo-2-methoxypyridine-3-carboxaldehyde ISO 9001：2015 REACH

158669-26-2

158669-26-3

Heterocycle-Pyridine series

Pyridine

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