BI 2536

Product Name: BI 2536
CAS No.: 755038-02-9
Chemical Name: BI 2536
Synonyms: BI 2536;CS-1984;BI-2536(R-);(R)-BI-2536;BI 2536, >=98%;BI2536/BI-2536;BI 2536 USP/EP/BP;BI 2536;BI-2536; BI2536;Boehringer PLK-1 inhibitor;BI-2536, BoehringerPLK-1 inhibitor
CBNumber: CB31562104
Molecular Formula: C28H39N7O3
Formula Weight: 521.65
MOL File: 755038-02-9.mol

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BI 2536 Property

Density: 1.28
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 25 mg/ml)
form: Yellow powder.
pka: 14.09±0.20(Predicted)
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey: XQVVPGYIWAGRNI-JOCHJYFZSA-N
SMILES: C(NC1CCN(C)CC1)(=O)C1=CC=C(NC2=NC=C3C(=N2)N(C2CCCC2)[C@H](CC)C(=O)N3C)C(OC)=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17385
Product name: BI 2536
Purity: ≥95%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 17385
Product name: BI 2536
Purity: ≥95%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 17385
Product name: BI 2536
Purity: ≥95%
Packaging: 10mg
Price: $178
Updated: 2024/03/01

Cayman Chemical

Product number: 17385
Product name: BI 2536
Purity: ≥95%
Packaging: 50mg
Price: $758
Updated: 2024/03/01

TRC

Product number: B373470
Product name: BI2536
Packaging: 5mg
Price: $105
Updated: 2021/12/16

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BI 2536 Chemical Properties,Usage,Production

Description

BI 2536 (755038-02-9) was originally reported as a potent (IC50’s Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM)1?and selective2?Polo-like kinase inhibitor?that caused mitotic arrest and apoptosis induction in various human cancer cell lines.1?It was later found to be a potent inhibitor (IC50?= 100nM) of BET family member BRD4 and able to potently suppress c-Myc expression in MM.1S multiple myeloma cells.3?BI 2536 destabilizes N-Myc by inhibiting the deactivation of the ubiquitin E3 ligase Fbw7 by Plk1.4

Uses

BI 2536 is a PLK1 inhibitor, inducing apoptosis together with micro-tubule-destabilizing drugs in preclinical rhabdomyosarcoma models. Anti-cancer and potent PLK1 inhibitor.

target

Plk1

References

1) Steegmaier?et al.?(2007),?BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo; Curr. Biol.,?17?316 2) Davis?et al.?(2011),?Comprehensive analysis of kinase inhibitor selectivity; Nat. Biotechnol.,?29?1046 3) Ciceri?et al.?(2014),?Dual kinase-bromodomain inhibitors for rationally designed polypharmacology; Nat. Chem. Biol.,?10?305 4) Xiao?et al.?(2016),?Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell Survival; Mol. Cell,?64?493

BI 2536 Preparation Products And Raw materials

Raw materials

Preparation Products

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BI 2536 Suppliers

China 137 Germany 1 India 1 The Netherlands 1 United Kingdom 1 United States 23 Global 164

MedChemexpress LLC

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755038-02-9, BI 2536Related Search:

D-ERYTHRO-SPHINGOSINE Bortezomib Alisertib (MLN8237) PD 0332991 HCl Volasertib (BI 6727) Afatinib Olaparib Selumetinib BML-275 PLX-4720 CX-4945 Fluoxetine hydrochloride Alpelisib (BYL719) Tubastatin A hydrochloride N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide hydrochloride Neratinib Glucagon Receptor Antagonist I BI 2536

BI-2536, BoehringerPLK-1 inhibitor

4-[[(7R)-8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide

BI 2536

Benzamide, 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-

Boehringer PLK-1 inhibitor

BI-2536(R-)

BI2536/BI-2536

(R)-4-((8-cyclopentyl-7-ethyl-5-Methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)aMino)-3-Methoxy-N-(1-Methylpiperidin-4-yl)benzaMide

4-(8-cyclopentyl-7-ethyl-5-Methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylaMino)-3-Methoxy-N-(1-Methylpiperidin-4-yl)benzaMide

BI 2536 4-[[(7R)-8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide

BI 2536, >=98%

4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide

BI 2536;BI-2536; BI2536

(R)-BI-2536

CS-1984

(R)-4-((8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)amino)-3-methoxy-

BI 2536 USP/EP/BP

BI-2536 Plk1 inhibitor potent ATP-competitive

755038-02-9

755038-03-9

C28H39N7O3

Inhibitors

API