ChemicalBook > CAS DataBase List > BUCLIZINE, DIHYDROCHLORIDE

BUCLIZINE, DIHYDROCHLORIDE

Product Name
BUCLIZINE, DIHYDROCHLORIDE
CAS No.
129-74-8
Chemical Name
BUCLIZINE, DIHYDROCHLORIDE
Synonyms
POSDEL;BUCLINA;softran;aphilanr;buclodin;UCB-4445;VIBAZINE;LONGIFENE;BUCLIZINE 2HCL;1-(4-(tert-Butyl)
CBNumber
CB3156784
Molecular Formula
C28H35Cl3N2
Formula Weight
505.95
MOL File
129-74-8.mol
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BUCLIZINE, DIHYDROCHLORIDE Property

Melting point:
230-240°C
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly)
form 
powder
color 
white to beige
Stability:
Hygroscopic
CAS DataBase Reference
129-74-8
EPA Substance Registry System
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-, dihydrochloride (129-74-8)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1591
Product name
Buclizine dihydrochloride
Purity
≥98% (HPLC)
Packaging
50mg
Price
$120
Updated
2024/03/01
Cayman Chemical
Product number
25641
Product name
Buclizine (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
25641
Product name
Buclizine (hydrochloride)
Purity
≥98%
Packaging
100mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
25641
Product name
Buclizine (hydrochloride)
Purity
≥98%
Packaging
500mg
Price
$199
Updated
2024/03/01
Cayman Chemical
Product number
25641
Product name
Buclizine (hydrochloride)
Purity
≥98%
Packaging
1g
Price
$335
Updated
2024/03/01
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BUCLIZINE, DIHYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

BUCLIZINE, DIHYDROCHLORIDE is Off-White Powder

Originator

Longifine,UCB

Uses

BUCLIZINE, DIHYDROCHLORIDE used as an antiemetic

Definition

ChEBI: Buclizine dihydrochloride is a hydrochloride salt that is obtained by reaction of buclizine with 2 equivalents of hydrogen chloride. It has a role as a central nervous system depressant, a local anaesthetic, a histamine antagonist, a cholinergic antagonist and an antiemetic. It contains a buclizine(2+).

Manufacturing Process

1 mol 4-chlorobenzhydril chloride was heated in toluene to reflux with 1 mol ethyl ester of piperazine 1-carboxylic acid at about 150°C in a presence of an excess of triethyl amine. On cooling the triethyl amine hydrochloride was filtered off, a solvent was removed in vacuum and the residue [(4-chlorophenyl)- phenyl-methyl]piperazine carboxylic acid ethyl ester was boiled straight away with potassium hydroxide in ethanol for 48 hours. After removing ethanol in vacuum to dryness, the residue was dissolved in benzene and washed with water. The benzene solution was dried, benzene removed in vacuum. The residue was distilled to give 4-chlorobezhydryl-piperazine. It had given the desired 1-(p-tert-butylbenzyl)-4-(p-chloro-α-phenylbenzyl)- piperazine, buclizine, by a reaction with 4-tert-butylbenzyl chloride in the presence of any halogen hydrochloride acceptor (triethyl amine, sodium or potassium carbonate and so on). The obtained product had BP: 230°- 240°C/0.001 mm Hg.

brand name

Bucladin (Stuart).

Therapeutic Function

Antihistaminic, Antiallergic, Antinauseant, Tranquilizer, Appetite stimulant

General Description

Buclizine hydrochloride, l-(p-tertbutylbenzyl)-4-(p-chloro-α-phenylbenzyl)piperazinedihydrochloride (Bucladin-S), is a white to slightly yellowcrystalline powder that is insoluble in water. The highlylipid-soluble buclizine has CNS depressant, antiemetic, andantihistaminic properties. This drug has been discontinued inthe United States.

Safety Profile

Poison by intraperitoneal route. An experimental teratogen. When heated to decomposition it emits very toxic fumes of NOx, and HCl.

BUCLIZINE, DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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BUCLIZINE, DIHYDROCHLORIDE Suppliers

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View Lastest Price from BUCLIZINE, DIHYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
BUCLIZINE, DIHYDROCHLORIDE 129-74-8
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200kgs
Release date
2020-01-28

129-74-8, BUCLIZINE, DIHYDROCHLORIDERelated Search:

BUCLIZINE, DIHYDROCHLORIDE 1-(4-Chlorobenzhydryl)piperazine 1-Benzylpiperazine BUCLIZINE CHLORCYCLIZINE 4-tert-Butylbenzylamine CHLORCYCLIZINE HYDROCHLORIDE Cyclizine 1-[(4-CHLOROPHENYL)PHENYLMETHYL]-PIPERAZINE DIHYDROCHLORIDE 1-(4-CHLOROBENZYL)PIPERAZINE 1-(4-METHYLBENZYL)PIPERAZINE 1-(4-ETHYL-BENZYL)-PIPERAZINE migraleve (4-CHLOROPHENYL)PHENYLMETHYLAMINE HYDROCHLORIDE Chlorcyclizine dihydrochloride N-(4-ISOPROPYLBENZYL)ETHANAMINE N-ISOPROPYLPIPERAZINE DIHYDROCHLORIDE 1-(4-TERT-BUTYLBENZYL)PIPERAZINE

  • 1-(p-tert-butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)-piperazindihydrochl
  • 1-(p-tert-butylbenzyl)-4-(p-chlorodiphenylmethyl)piperazinedihydrochloride
  • 1-(p-tert-butylbenzyl-4-p-chloro-alpha-phenylbenzyl)piperazinedihydrochlorid
  • 1-p-chlorobenzhydryl-4-p-(t)-butylbenzylpiperazinedihydrochloride
  • aphilanr
  • buclizinehydrochloride
  • buclodin
  • 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)meth
  • LONGIFENE
  • 1-(p-chlorobenzhydryl)-4-(p-t-butylbenzyl)diethylenediaminedihydrochloride
  • BUCLINA
  • BUCLIZINE, DIHYDROCHLORIDE
  • 1-(4-(tert-Butyl)
  • -4-((4-chlorophenyl)
  • UCB-4445
  • VIBAZINE
  • POSDEL
  • BUCLIZINE 2HCL
  • Histabutizine dihydrochloride
  • UCB-4445, Buclina, Longifene, Posdel, Vibazine
  • piperazine,1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]me
  • softran
  • 1-[(4-Chlorophenyl)phenylmethyl]-4-[[4-(tert-butyl)phenyl]methyl]piperazine dihydrochloride
  • 1-(4-(tert-Butyl)benzyl)-4-((4-chlorophenyl)(phenyl)Methyl)piperazine dihydrochloride
  • Buclizine Hydrochloride(BP/EP)
  • Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-, hydrochloride (1:2)
  • histabutyzinedihydrochloride
  • Buclizine USP/EP/BP
  • BUCLIZINE, DIHYDROCHLORIDE USP/EP/BP
  • Chlorphenazine hydrochloride
  • Buclizine HCl (UCB-4445)
  • Buclizine D8 DihydrochlorideQ: What is Buclizine D8 Dihydrochloride Q: What is the CAS Number of Buclizine D8 Dihydrochloride Q: What is the storage condition of Buclizine D8 Dihydrochloride
  • teratogen,Inhibitor,MCF-7,anti-tumor activity,antiallergic,antihistamine,inhibit,Histamine Receptor,Buclizine,Buclizine dihydrochloride
  • 1-(4-(tert-butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine hydrochloride
  • 129-74-8
  • C28H35Cl3N2
  • C28H33ClN22HCl
  • C28H37Cl3N2
  • C28H33ClN22ClH
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Inhibitors