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tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate

Product Name
tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate
CAS No.
167081-37-0
Chemical Name
tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate
Synonyms
trans-1-(Boc-aMino)-3-(hy...;tert-Butyl (trans-3-(hydroxymethyl);trans-3-(Boc-amino)cyclobutanemethanol,97%;trans-3-(Boc-aMino)cyclobutaneMethanol, 97%;BUTYL TRANS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE;trans-1-(Boc-aMino)-3-(hydroxyMethyl)cyclobutane;tert-butyl N-[3-(hydroxymethyl)cyclobutyl]carbamat;TERT-BUTYL TRANS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE;tert-butyl (1r,3r)-3-(hydroxymethyl)cyclobutylcarbamate;trans-1-(Boc-amino)-3-(hydroxymethyl)cyclobutane - SB7652
CBNumber
CB3158733
Molecular Formula
C10H19NO3
Formula Weight
201.26
MOL File
167081-37-0.mol
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tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate Property

Boiling point:
317.9±11.0 °C(Predicted)
Density 
1.08±0.1 g/cm3(Predicted)
pka
12.42±0.40(Predicted)
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Safety

HS Code 
2922500090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
H62719
Product name
trans-3-(Boc-amino)cyclobutanemethanol
Purity
97%
Packaging
250mg
Price
$184.65
Updated
2024/03/01
Alfa Aesar
Product number
H62719
Product name
trans-3-(Boc-amino)cyclobutanemethanol
Purity
97%
Packaging
1g
Price
$550.65
Updated
2024/03/01
Biosynth Carbosynth
Product number
FB53711
Product name
Tert-Butyl Trans-3-Hydroxymethylcyclobutylcarbamate
Packaging
500mg
Price
$580
Updated
2021/12/16
Matrix Scientific
Product number
089423
Product name
tert-Butyl trans-3-hydroxymethylcyclobutylcarbamate
Packaging
1g
Price
$1183
Updated
2021/12/16
SynQuest Laboratories
Product number
4256-1-27
Product name
trans-1-(Boc-amino)-3-(hydroxymethyl)cyclobutane
Packaging
5G
Price
$1250
Updated
2021/12/16
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tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate Chemical Properties,Usage,Production

Synthesis

To a stirred solution of methyl (1R,3R)-3-((tert-butoxycarbonyl)amino)cyclobutane-1-carboxylate (1.0 g, 4.4 mmol) in THF (20 mL) was added 3M lithium borohydride (9 mL, 9 mmol) at 0° C. Then the reaction mixture was heated and stirred at 60° C for 3 h. The reaction mixture was then transferred into dilute NaOH and the resulting mixture was extracted using ethyl acetate (3×50 mL). The combined organic layer was dried over anhydrous sodium sulfate and filtered. The filtrate was evaporated under reduced pressure and the crude product was purified using silica gel column chromatography (3% MeOH-DCM) to give tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate as a white solid (0.8 g, 91%).

Reactions

Tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate is an crucial organic compound that can be used to synthesize 3-Amino-cyclobutaneMethanol hydrochloride.

tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate Suppliers

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167081-37-0, tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamateRelated Search:

6-bromo-pyridine-2-carboxylic acid tert-butyl ester Ethylenediaminetetraacetic acid BOC-TRANS-1,3-AMINOCYCLOHEXANE CARBOXYLIC ACID ZBC tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate TRANS-3-(TERT-BUTOXYCARBONYLAMINO)CYCLOBUTANECARBOXYLIC ACID 3-[(TERT-BUTOXYCARBONYL)AMINO]BICYCLO[1.1.1]PENTANE-1-CARBOXYLIC ACID

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  • trans-3-(Boc-amino)cyclobutanemethanol,97%
  • tert-butyl N-[3-(hydroxymethyl)cyclobutyl]carbamat
  • 167081-37-0
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