tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate
- Product Name
- tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate
- CAS No.
- 167081-37-0
- Chemical Name
- tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate
- Synonyms
- trans-1-(Boc-aMino)-3-(hy...;tert-Butyl (trans-3-(hydroxymethyl);trans-3-(Boc-amino)cyclobutanemethanol,97%;trans-3-(Boc-aMino)cyclobutaneMethanol, 97%;BUTYL TRANS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE;trans-1-(Boc-aMino)-3-(hydroxyMethyl)cyclobutane;tert-butyl N-[3-(hydroxymethyl)cyclobutyl]carbamat;TERT-BUTYL TRANS-3-HYDROXYMETHYLCYCLOBUTYLCARBAMATE;tert-butyl (1r,3r)-3-(hydroxymethyl)cyclobutylcarbamate;trans-1-(Boc-amino)-3-(hydroxymethyl)cyclobutane - SB7652
- CBNumber
- CB3158733
- Molecular Formula
- C10H19NO3
- Formula Weight
- 201.26
- MOL File
- 167081-37-0.mol
tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate Property
- Boiling point:
- 317.9±11.0 °C(Predicted)
- Density
- 1.08±0.1 g/cm3(Predicted)
- pka
- 12.42±0.40(Predicted)
Safety
- HS Code
- 2922500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H62719
- Product name
- trans-3-(Boc-amino)cyclobutanemethanol
- Purity
- 97%
- Packaging
- 250mg
- Price
- $184.65
- Updated
- 2024/03/01
- Product number
- H62719
- Product name
- trans-3-(Boc-amino)cyclobutanemethanol
- Purity
- 97%
- Packaging
- 1g
- Price
- $550.65
- Updated
- 2024/03/01
- Product number
- FB53711
- Product name
- Tert-Butyl Trans-3-Hydroxymethylcyclobutylcarbamate
- Packaging
- 500mg
- Price
- $580
- Updated
- 2021/12/16
- Product number
- 089423
- Product name
- tert-Butyl trans-3-hydroxymethylcyclobutylcarbamate
- Packaging
- 1g
- Price
- $1183
- Updated
- 2021/12/16
- Product number
- 4256-1-27
- Product name
- trans-1-(Boc-amino)-3-(hydroxymethyl)cyclobutane
- Packaging
- 5G
- Price
- $1250
- Updated
- 2021/12/16
tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate Chemical Properties,Usage,Production
Synthesis
To a stirred solution of methyl (1R,3R)-3-((tert-butoxycarbonyl)amino)cyclobutane-1-carboxylate (1.0 g, 4.4 mmol) in THF (20 mL) was added 3M lithium borohydride (9 mL, 9 mmol) at 0° C. Then the reaction mixture was heated and stirred at 60° C for 3 h. The reaction mixture was then transferred into dilute NaOH and the resulting mixture was extracted using ethyl acetate (3×50 mL). The combined organic layer was dried over anhydrous sodium sulfate and filtered. The filtrate was evaporated under reduced pressure and the crude product was purified using silica gel column chromatography (3% MeOH-DCM) to give tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate as a white solid (0.8 g, 91%).
Reactions
Tert-Butyl (trans-3-(hydroxymethyl)cyclobutyl)carbamate is an crucial organic compound that can be used to synthesize 3-Amino-cyclobutaneMethanol hydrochloride.