Enalaprilat

ChemicalBook > CAS DataBase List > Enalaprilat

Product Name: Enalaprilat
CAS No.: 76420-72-9
Chemical Name: Enalaprilat
Synonyms: Vasotec IV;Enalaprilat;MK 421 diacid;Enalapril acid;Enalapril diacid;Enalaprilic Acid;ENALAPRILAT HYDRATE;Enalaprilat USP/EP/BP;enalaprilat (anhydrous);Enalapril maleate impurity C
CBNumber: CB3163049
Molecular Formula: C18H24N2O5
Formula Weight: 348.39
MOL File: 76420-72-9.mol

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Enalaprilat Property

Melting point:: 148-151°C
alpha: D -67.0° (0.1M HCl)
Boiling point:: 601.0±55.0 °C(Predicted)
Density: 1.286±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Very slightly soluble or slightly soluble in water, sparingly soluble in methanol, practically insoluble in acetonitrile.
pka: pKa 2.30 (Uncertain);3.39 (Uncertain)
Water Solubility: Soluble in water with heating (~60°C)
CAS DataBase Reference: 76420-72-9(CAS DataBase Reference)
EPA Substance Registry System: L-Proline, N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl- (76420-72-9)

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 43301
Product name: Enalaprilat
Purity: analytical standard
Packaging: 25mg
Price: $167
Updated: 2024/03/01

Alfa Aesar

Product number: J63392
Product name: Enalaprilat
Packaging: 10mg
Price: $143.65
Updated: 2024/03/01

Alfa Aesar

Product number: J63392
Product name: Enalaprilat
Packaging: 50mg
Price: $414.65
Updated: 2024/03/01

Adipogen Life Sciences

Product number: CDX-E0090-M250
Product name: Enalaprilat
Purity: ≥99%(HPLC)
Packaging: 250mg
Price: $424
Updated: 2021/12/16

Biosynth Carbosynth

Product number: IE63755
Product name: Enalapril maleate impurity C
Packaging: 250mg
Price: $125
Updated: 2021/12/16

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Enalaprilat Chemical Properties,Usage,Production

Description

Enalaprilat is the diacid active metabolite of enalapril. As an injectable ACE inhibitor, it is reportedly useful in the treatment of uncomplicated accelerated hypertension and hypertensive emergencies. Enalaprilat is more effective in reducing blood pressure in the elderly than in the young, despite the fact that renin activity is lower in old age.

Chemical Properties

White Crystalline Solid

Originator

Merck (USA)

Uses

Enalapril is a ACE (angiotensin-converting enzyme) inhibitor, suggested to be more potent than Captopril (sc-200566). Studies indicate that Enalapril downregulates the expression of IL-β, IL-6, and NF-κB. Further studies show that Enalapril upregulates the expression of VEGF and heme oxygenase-1. Enalaprilat reports demonstrate that the compound has some antioxidant activity, which does not include the PKC-NADPH oxidase pathway.

Uses

Active metabolite of Enalapril. A nonsulfhydryl dipeptide angiotensin converting enzyme (ACE) inhibitor

Uses

primary hypertension

Definition

ChEBI: Enalapril in which the ethyl ester group has been hydrolysed to the corresponding carboxylic acid. Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor and is used (often in the form of its prodrug, enalapril) in the treatment of hypertension an heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is g ven by intravenous injection, usually as the dihydrate.

brand name

Vasotec (Biovail);Renitec.

Enalaprilat Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Enalaprilat manufacturers

Guangzhou PI PI BIOTECH INC

Product: Enalapril Maleate Impurity C(EP) 76420-72-9
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 90%+
Supply Ability: 10g
Release date: 2020-06-04

Guangzhou PI PI BIOTECH INC

Product: Enalapril Maleate Impurity C(EP) 76420-72-9
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 90%+
Supply Ability: 10g
Release date: 2021-09-20

Dideu Industries Group Limited

Product: Enalaprilat 76420-72-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-10

76420-72-9, EnalaprilatRelated Search:

Propyl butyrate Enalapril Propyl gallate Glycine Pyrrolidine cis-4-Hydroxy-L-proline Methyl 3-oxovalerate PHENYL VALERATE Propionyl bromide L-PROLINE-(4-3H(N)) L-Alanyl-L-Glutamine Phenylhydrazine Enalapril maleate ALTRENOGEST ENALAPRILAT DIHYDRATE,ENALAPRILAT USP Nifedipine Eplerenone Idarubicin

ENALAPRILAT HYDRATE

ENALAPRILAT USP(CRM STANDARD)

Enalaprilat (Enalapril EP Impurity C)

Enalapril maleate impurity C

Enalapril acid

L-Proline, 1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-, (S)-

N-[1(S)-Carboxy-3-phenylpropyl]-L-alanyl-L-proline

1-[N-[(S)-1-Carboxy-3-phenylpropyl]-L-alanyl]-L-proline

Enalapril diacid

(2S)-1-[(2S)-2-{[(2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]aMino}propanoyl]pyrrolidine-2-carboxylic acid

Enalaprilat(Enalapril IMpurity C)

N-[(1S)-1-Carboxy-3-phenylpropyl]-L-alanyl-L-proline

L-Proline, N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-

(S)-1-((S)-2-(((S)-1-Carboxy-3-phenylpropyl)amino)propanoyl)pyrrolidine-2-carboxylic acid

enalaprilat (anhydrous)

Enalaprilic Acid

N-[(1S)-1-(Carboxy)-3-phenylpropyl]-L-alanyl]-L-proline Dihydrate

Vasotec IV

(2S)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenyl-propyl]amino]propanoyl]pyrrolidine-2-carboxylic acid

Enalaprilat

(2S)-1-[(2S)-2-[[(1S)-1-Carboxy-3-p

Enalaprilat USP/EP/BP

Enalaprilat DISCONTINUED. Please see E555375.

Enalapril maleate EP Impurity C

EnalaprilatQ: What is Enalaprilat Q: What is the CAS Number of Enalaprilat Q: What is the storage condition of Enalaprilat Q: What are the applications of Enalaprilat

MK 421 diacid

76420-72-9

C18H28N2O7

C18H24N2O52H2O

C18H24N2O5

Metabolite

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Various Metabolites and Impurities

Active Pharmaceutical Ingredients