Description References
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Dexpanthenol

Description References
Product Name
Dexpanthenol
CAS No.
81-13-0
Chemical Name
Dexpanthenol
Synonyms
D-PANTHENOL;Provitamin B5;D-PANTOTHENYL ALCOHOL;D-PANTOTHENOL;(R)-2,4-DIHYDROXY-N-(3-HYDROXYPROPYL)-3,3-DIMETHYLBUTYRAMIDE;Bepanthen;Pantol;Pantenyl;PROVITAMIN B;PANTHENOL, D-
CBNumber
CB3169304
Molecular Formula
C9H19NO4
Formula Weight
205.25
MOL File
81-13-0.mol
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Dexpanthenol Property

Melting point:
64~69℃
alpha 
30.5 º (c=5, H2O on anh. sub)
Boiling point:
118-120 °C (2.7 mmHg)
Density 
1.20 g/mL at 20 °C (lit.)
vapor pressure 
0Pa at 25℃
refractive index 
1.495-1.502
Flash point:
118-120°C/0.02m
storage temp. 
2-8°C
solubility 
DMSO (Sparingly), Methanol (Slightly), Water (Sparingly)
pka
13.03±0.20(Predicted)
form 
Viscous Liquid or Semi Solid
color 
Clear colorless to slightly yellow
PH
pH (100g/l,25℃) : 8.5~10.5
optical activity
[α]20/D +30±1°, c = 5% in H2O
Water Solubility 
soluble
Sensitive 
Hygroscopic
Merck 
14,2947
BRN 
1724947
InChIKey
SNPLKNRPJHDVJA-ZETCQYMHSA-N
LogP
-1.06 at 22℃
CAS DataBase Reference
81-13-0(CAS DataBase Reference)
NIST Chemistry Reference
Dexpanthenol(81-13-0)
EPA Substance Registry System
(+)-Panthenol (81-13-0)
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-48-41-37/38-20/21/22
Safety Statements 
23-24/25-45-36/37/39-26-22
WGK Germany 
1
RTECS 
ES4316000
3-10
TSCA 
Yes
HS Code 
29241990
Hazardous Substances Data
81-13-0(Hazardous Substances Data)
Toxicity
LD50 oral in mouse: 15gm/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
76200
Product name
D-Panthenol
Purity
≥98.0% (NT)
Packaging
25ml
Price
$59.1
Updated
2024/03/01
Sigma-Aldrich
Product number
1179504
Product name
Dexpanthenol
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500mg
Price
$466
Updated
2024/03/01
TCI Chemical
Product number
P0692
Product name
D-Panthenol
Purity
>98.0%(T)
Packaging
25g
Price
$38
Updated
2024/03/01
TCI Chemical
Product number
P0692
Product name
D-Panthenol
Purity
>98.0%(T)
Packaging
500g
Price
$253
Updated
2024/03/01
Alfa Aesar
Product number
A18499
Product name
D-Panthenol, 98+%
Packaging
100g
Price
$55.6
Updated
2024/03/01
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Dexpanthenol Chemical Properties,Usage,Production

Description

Dexpanthenol belongs to a derivative of pantothenic acid (vitamin B5). It can penetrate the skin and mucous membrane to be quickly oxidized to pantothenic acid. The later one is extremely hygroscopic and binds water effectively. Therefore, Dexpanthenol can be used as a moisturizer. It is added to pharmaceutical and cosmetic products to relieve itching and improve wound healing. In ointments, it can be used for the treatment of sunburns, mild burns, minor skin injuries and disorders. It is also immediately applied after major abdominal surgery to minimize the possibility of paralytic ileus. In addition, it can also be supplemented into the commercial shampoos and hair conditioners to lubricate the hair shaft and give the hair a shiny appearance. The exact mechanism of action of Dexpanthenol is still unclear, perhaps through its enhancing effect on acetylcholine.  

References

https://pubchem.ncbi.nlm.nih.gov/compound/Dexpanthenol#section=Top
https://www.drugs.com/pro/dexpanthenol.html
https://de.wikipedia.org/wiki/Dexpanthenol

Chemical Properties

clear colorless to slightly yellow viscous liquid

Originator

Bepanthene,Roche,France,1951

Uses

Dexpanthenol may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques as well as partial least-squares multivariate calibration.

Uses

D-Panthenol is an analogue of pantothenic acid (P190300), a member of the B complex vitamins. D-Panthenol is the biologically active enantiomer of Panthenol.

Uses

cholinergic

Uses

immunosuppressant, mitoxantrone analogue less toxic on cardiac tissue antineoplastic

Definition

ChEBI: Pantothenol is a monocarboxylic acid amide that is 3,3-dimethylbutanamide substituted by hydroxy groups at positions 2 and 4 and a 3-hydroxypropyl group at the carbomyl nitrogen. It has a role as a cholinergic drug and a provitamin. It is an amino alcohol and a monocarboxylic acid amide.

Manufacturing Process

130 parts by weight of d(-)-α-hydroxy-β,β-dimethyl-gamma-butyric acid lactone are dissolved in 150 parts by volume of methyl alcohol. 75 parts by weight of 3-hydroxypropylamine are added, in one portion, to the solution and the mixture is well stirred. While the reaction sets in, the temperature of the mixture gradually rises by itself to about 50°C and then drops again after about two hours. To cause completion of the reaction, the mixture is allowed to stand at room temperature for 24 hours. The so obtained (d+)-α,γdihydroxy-β,β-dimethyl-butyric-acid-(3'-hydroxypropyl)-amide is freed from methyl alcohol in vacuo. It is a colorless, viscous oil, easily soluble in water. It boils under a pressure of 0.02 mm between 118° and 120°C.

brand name

D-Panthenol 50 (BASF); Ilopan (Savage); Motilyn (Abbott).

Therapeutic Function

Gastrointestinal drug

General Description

Dexpanthenol is an alcohol analog of pantothenic acid and an important component of parenterals, local cosmetic preparations and multi-vitamins. It has as much biological activity as pantothenic acid and is found to be stable in aqueous solution.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Flammability and Explosibility

Non flammable

Biochem/physiol Actions

D-Panthenol is the alcohol analogue and biological precursor of D-pantothenic acid. These analogues are precursors in the biosynthesis of coenzyme A. D-Panthenol and D-Pantothenic acid are used in a variety of skin protection products. D-pantothenic acid may have a role in controlling keratinocyte proliferation and differentiation. D-Panthenol may be used for studies of skin protection emulsions from UV irradiation and as a humectant.

Contact allergens

Pan(to)thenol is the alcohol corresponding to pantothenic acid, of the vitamin B5 group. It is used as a food additive, and in skin and hair products as a conditioning agent. Contact dermatitis and urticaria have been reported.

Safety Profile

Moderately toxic by intravenous route. A skin and eye irritant. When heated to decomposition it emits toxic fumes of NOx. See also AMIDES.

Veterinary Drugs and Treatments

Dexpanthenol has been suggested for use in intestinal atony or distension, postoperative retention of flatus and feces, prophylaxis and treatment of paralytic ileus after abdominal surgery or traumatic injuries, equine colic (not due to mechanical obstruction) and any other condition when there is an impairment of smooth muscle function. Controlled studies are lacking with regard to proving the efficacy of the drug for any of these indications.

Purification Methods

Purify D-panthenol by distillation in vacuo. It is a slightly hygroscopic viscous oil and is soluble in H2O and organic solvents. It is hydrolysed by alkali and strong acid. [Rabin J Am Pharm Assoc (Sci Ed) 37 502 1948, Bonati & Pitré Farmaco Ed Scient 14 43 1959, Beilstein 4 IV 1652.]

Dexpanthenol Preparation Products And Raw materials

Raw materials

Preparation Products

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Dexpanthenol Suppliers

Hefei TNJ Chemical Industry Co.,Ltd.
Tel
551-65418679 15837135945
Fax
0551-65418697
Email
info@tnjchem.com
Country
China
ProdList
1889
Advantage
62
Wuhan deyuancheng Biotechnology Co., Ltd
Tel
027-87887055 13986003651
Fax
027-87182808
Email
1169749983@qq.com
Country
China
ProdList
453
Advantage
58
Yangzhou juhechang Technology Co., Ltd
Tel
0514-0514-83662002 13073488988
Fax
0514-83662002
Email
13073488988@163.com
Country
China
ProdList
37
Advantage
58
Spec-Chem Industry Inc.
Tel
13505162978
Email
sc@specchemind.com
Country
China
ProdList
93
Advantage
58
Suzhou Yuanrui Bio-Tech Co., Ltd
Tel
18106132862 18106132862
Email
sales02@yuanruibio.com
Country
China
ProdList
144
Advantage
58
BLiT (Hefei)Chemical Co.,Ltd
Tel
17720572443
Email
bright@blitchem.com
Country
China
ProdList
287
Advantage
58
Tianjin Zhongxin Chemtech Co., Ltd.
Tel
022-66880623
Fax
86(0)22-66880086
Email
sales@tjzxchem.com
Country
China
ProdList
614
Advantage
60
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
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View Lastest Price from Dexpanthenol manufacturers

Hebei Yime New Material Technology Co., Ltd.
Product
d panthenol 81-13-0
Price
US $35.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000kg/week
Release date
2023-11-17
Jinan Finer Chemical Co., Ltd
Product
Dexpanthenol 81-13-0
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
500mt/year
Release date
2021-08-31
BLiT (Hefei)Chemical Co.,Ltd
Product
D-PANTHENOL 81-13-0
Price
US $0.00/KG
Min. Order
1KG
Purity
75%/98%
Supply Ability
300TONS
Release date
2024-03-28

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