4-Methylphenylhydrazine hydrochloride
- Product Name
- 4-Methylphenylhydrazine hydrochloride
- CAS No.
- 637-60-5
- Chemical Name
- 4-Methylphenylhydrazine hydrochloride
- Synonyms
- P-TOLYLHYDRAZINE HYDROCHLORIDE;P-METHYLPHENYLHYDRAZINE HYDROCHLORIDE;Tolyl Hydrazine Hcl;4-TOLYLHYDRAZINE HCL;P-TOLYL HYDRAZINE HCL;PARA-TOLYLHYDRAZINEHCL;p-tolylhydrazine HCl salt;4-METHYLPHENYLHYDRAZINE HCL;p-tolyl-hydrazinhydrochloride;p-tolyhydrazine hydrochloride
- CBNumber
- CB3178719
- Molecular Formula
- C7H11ClN2
- Formula Weight
- 158.63
- MOL File
- 637-60-5.mol
4-Methylphenylhydrazine hydrochloride Property
- Melting point:
- >200 °C (dec.)(lit.)
- Boiling point:
- 217.6°C (rough estimate)
- Density
- 0.9532 (rough estimate)
- refractive index
- 1.6230 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO, Methanol
- form
- Flaky Powder
- color
- Off-white to beige-brownish
- Water Solubility
- soluble
- Merck
- 14,9542
- BRN
- 3563996
- CAS DataBase Reference
- 637-60-5(CAS DataBase Reference)
- EPA Substance Registry System
- Hydrazine, (4-methylphenyl)-, monohydrochloride (637-60-5)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38-40
- Safety Statements
- 26-36-36/37/39
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- MW0195000
- Hazard Note
- Harmful/Irritant
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29280090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H317May cause an allergic skin reaction
H350May cause cancer
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- T40606
- Product name
- p-Tolylhydrazine hydrochloride
- Purity
- 98%
- Packaging
- 25g
- Price
- $155
- Updated
- 2025/07/31
- Product number
- T0319
- Product name
- p-Tolylhydrazine Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $39
- Updated
- 2025/07/31
- Product number
- T0319
- Product name
- p-Tolylhydrazine Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 250g
- Price
- $197
- Updated
- 2021/12/16
- Product number
- T536610
- Product name
- 4-TolylhydrazineMonohydrochloride
- Packaging
- 10g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 3739-5-X4
- Product name
- 4-Methylphenylhydrazine hydrochloride
- Purity
- 98%
- Packaging
- 100g
- Price
- $192
- Updated
- 2021/12/16
4-Methylphenylhydrazine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
off-white to beige-brownish flaky powder
Uses
4-Tolylhydrazine Monohydrochloride has shown tumorigenic potential through studies. In addition, due to its hydrazine moiety, it has anti-cancer potential and is a compound from which derivatives are made in the search of novel anticancer drugs.
Synthesis
106-49-0
637-60-5
General procedure for the synthesis of 4-methylphenylhydrazine hydrochloride from 4-methylaniline: 4-methylaniline (10.7 g, 0.1 mol) was mixed with dilute hydrochloric acid in a 200 ml round bottom flask. Sodium nitrite solution (30 ml, 7.3 g, 0.105 mol) was added slowly and dropwise to the above mixture. The reaction mixture was stirred for 1 hour and then filtered. The filtered clear liquid was added dropwise to 70 ml of aqueous solution containing sodium sulfite (37.8 g, 0.3 mol) and reacted at 80°C for about 1.5 hours. Subsequently, concentrated hydrochloric acid (25 ml, 0.3 mol) was added slowly and the reaction temperature was raised to 95°C and the reaction continued for about 2.5 hours. Upon completion of the reaction, the mixture was allowed to stand at room temperature overnight to precipitate 4-methylphenylhydrazine hydrochloride as a solid. After filtration and drying, 12.9 g of product was obtained in 90.0% yield.
References
[1] Patent: CN108623511, 2018, A. Location in patent: Paragraph 0021
[2] Patent: EP2157088, 2010, A1. Location in patent: Page/Page column 41-42
[3] Russian Chemical Bulletin, 2005, vol. 54, # 10, p. 2417 - 2424
[4] European Journal of Medicinal Chemistry, 2010, vol. 45, # 10, p. 4692 - 4696
[5] European Journal of Medicinal Chemistry, 2011, vol. 46, # 5, p. 1706 - 1712
4-Methylphenylhydrazine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
4-Methylphenylhydrazine hydrochloride Suppliers
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- Fax
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- chemcontrol@nextra.sk
- Country
- Slovakia
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- 6700
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View Lastest Price from 4-Methylphenylhydrazine hydrochloride manufacturers
- Product
- 4-Methylphenylhydrazine hydrochloride 637-60-5
- Price
- US $50.00-20.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-12-05
- Product
- 4-Methylphenylhydrazine hydrochloride 637-60-5
- Price
- US $10.00-0.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-12
- Product
- 4-Methylphenylhydrazine hydrochloride 637-60-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11