2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
- Product Name
- 2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
- CAS No.
- 1054483-78-1
- Chemical Name
- 2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
- Synonyms
- 2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-;5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2;2-Hydroxypyridin-5-ylboronic acid pinacol ester;2-HYDROXYPYRIDINE-5-BORONIC ACID, PINACOL ESTER;6-HYDROXYPYRIDIN-3-YLBORONIC ACID, PINACOL ESTER;6-HYDROXY-PYRIDINE-3-BORONIC ACID, PINACOL ESTER;5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ol;5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ol;2-Hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyr...;5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-2(1H)-pyridinone
- CBNumber
- CB3181940
- Molecular Formula
- C11H16BNO3
- Formula Weight
- 221.06
- MOL File
- Mol file
2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Property
- Melting point:
- 197-198
- Density
- 1.10±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 11.98±0.10(Predicted)
- form
- solid
- color
- White
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-38-36
- Safety Statements
- 26-36/37/39
- WGK Germany
- 2
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 706094
- Product name
- 6-Hydroxypyridine-3-boronic acid pinacol ester
- Purity
- 97%
- Packaging
- 250mg
- Price
- $91.2
- Updated
- 2025/07/31
- Product number
- 706094
- Product name
- 6-Hydroxypyridine-3-boronic acid pinacol ester
- Purity
- 97%
- Packaging
- 1g
- Price
- $146.3
- Updated
- 2025/07/31
- Product number
- H953180
- Product name
- 6-Hydroxypyridine-3-boronic acid pinacol ester
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 279551
- Product name
- 6-Hydroxypyridine-3-boronic acid pinacol ester
- Packaging
- 250mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- OR60007
- Product name
- 2-Hydroxypyridine-5-boronic acid, pinacol ester
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Chemical Properties,Usage,Production
Uses
6-Hydroxypyridine-3-boronic acid pinacol ester can be used as a reactant:
- In the synthesis of novel glutamate transporter EAAT2 activators.
- To prepare crizotinib derivatives as SHIP2 inhibitors.
Uses
2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE is used in the preparation of modified C3 Betulinic acid (B330250) derivatives as HIV maturation inhibitors.
Synthesis
13466-38-1
73183-34-3
1054483-78-1
Using 2-hydroxy-5-bromopyridine (SM1, 0.1 g, 0.57 mmol) and pinacol ester of bisboronic acid (SM2, 0.88 g, 3.45 mmol) as raw materials, under argon protection, SM1, SM2, tricyclohexylphosphine (0.032 g, 0.114 mmol), Pd2(dba)3 (0.052 g, 0.057 mmol) and KOAc (0.17 g, 1.71 mmol) were dissolved in dioxane (10 mL). The reaction mixture was transferred to a sealed tube and the reaction was stirred at 110 °C overnight. The progress of the reaction was monitored by LC-MS and after confirming complete consumption of the feedstock, the solvent was removed under reduced pressure. The residue was diluted with brine and extracted with EtOAc. The organic phases were combined, dried over anhydrous Na2SO4 and concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent: 50% EA/PE) to afford the target compound 2-hydroxypyridine-5-boronic acid pinacol ester (Compound 3, 0.08 g, 64%) as a black liquid.
References
[1] Patent: WO2016/44770, 2016, A1. Location in patent: Page/Page column 644
2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Suppliers
- Tel
- --
- Fax
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- info@trc-canada.com
- Country
- Canada
- ProdList
- 6038
- Advantage
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View Lastest Price from 2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE manufacturers
- Product
- 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ol 1054483-78-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-10-03
- Product
- 6-Hydroxypyridine-3-boronic acid pinacol ester 1054483-78-1
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-07-05
- Product
- 2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 1054483-78-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-26