ChemicalBook > CAS DataBase List > 2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

Product Name
2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
CAS No.
1054483-78-1
Chemical Name
2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
Synonyms
2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-;5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2;2-Hydroxypyridin-5-ylboronic acid pinacol ester;2-HYDROXYPYRIDINE-5-BORONIC ACID, PINACOL ESTER;6-HYDROXYPYRIDIN-3-YLBORONIC ACID, PINACOL ESTER;6-HYDROXY-PYRIDINE-3-BORONIC ACID, PINACOL ESTER;5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ol;5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ol;2-Hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyr...;5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-2(1H)-pyridinone
CBNumber
CB3181940
Molecular Formula
C11H16BNO3
Formula Weight
221.06
MOL File
Mol file
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2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Property

Melting point:
197-198
Density 
1.10±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
11.98±0.10(Predicted)
form 
solid
color 
White
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-38-36
Safety Statements 
26-36/37/39
WGK Germany 
2
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
706094
Product name
6-Hydroxypyridine-3-boronic acid pinacol ester
Purity
97%
Packaging
250mg
Price
$91.2
Updated
2025/07/31
Sigma-Aldrich
Product number
706094
Product name
6-Hydroxypyridine-3-boronic acid pinacol ester
Purity
97%
Packaging
1g
Price
$146.3
Updated
2025/07/31
TRC
Product number
H953180
Product name
6-Hydroxypyridine-3-boronic acid pinacol ester
Packaging
250mg
Price
$70
Updated
2021/12/16
Usbiological
Product number
279551
Product name
6-Hydroxypyridine-3-boronic acid pinacol ester
Packaging
250mg
Price
$350
Updated
2021/12/16
Apolloscientific
Product number
OR60007
Product name
2-Hydroxypyridine-5-boronic acid, pinacol ester
Packaging
5g
Price
$370
Updated
2021/12/16
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2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Chemical Properties,Usage,Production

Uses

6-Hydroxypyridine-3-boronic acid pinacol ester can be used as a reactant:

  • In the synthesis of novel glutamate transporter EAAT2 activators.
  • To prepare crizotinib derivatives as SHIP2 inhibitors.

Uses

2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE is used in the preparation of modified C3 Betulinic acid (B330250) derivatives as HIV maturation inhibitors.

Synthesis

13466-38-1

73183-34-3

1054483-78-1

Using 2-hydroxy-5-bromopyridine (SM1, 0.1 g, 0.57 mmol) and pinacol ester of bisboronic acid (SM2, 0.88 g, 3.45 mmol) as raw materials, under argon protection, SM1, SM2, tricyclohexylphosphine (0.032 g, 0.114 mmol), Pd2(dba)3 (0.052 g, 0.057 mmol) and KOAc (0.17 g, 1.71 mmol) were dissolved in dioxane (10 mL). The reaction mixture was transferred to a sealed tube and the reaction was stirred at 110 °C overnight. The progress of the reaction was monitored by LC-MS and after confirming complete consumption of the feedstock, the solvent was removed under reduced pressure. The residue was diluted with brine and extracted with EtOAc. The organic phases were combined, dried over anhydrous Na2SO4 and concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent: 50% EA/PE) to afford the target compound 2-hydroxypyridine-5-boronic acid pinacol ester (Compound 3, 0.08 g, 64%) as a black liquid.

References

[1] Patent: WO2016/44770, 2016, A1. Location in patent: Page/Page column 644

2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Suppliers

Canada 1 China 99 Germany 1 India 3 Japan 1 United Kingdom 1 United States 13 Global 119
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View Lastest Price from 2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ol 1054483-78-1
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-10-03
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
6-Hydroxypyridine-3-boronic acid pinacol ester 1054483-78-1
Price
US $3.00-9.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-07-05
Dideu Industries Group Limited
Product
2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 1054483-78-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-09-26

1054483-78-1, 2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINERelated Search:

2-METHOXYL-3-FLUORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE 3-FORMYL-2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER 2-ETHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 2-METHOXY-4-METHYL-3-NITROPYRIDINE-5-BORONIC ACID PINACOL ESTER 2,6-DIMETHOXY-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 2-(CYCLOPROPYLMETHOXY)-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 2-BENZYLOXYPYRIDINE-5-BORONIC ACID, PINACOL ESTER 2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 2-(Tetrahydropyran-4-yloxy)pyridine-5-boronic acid, pinacol ester 3-CHLORO-2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER Dimethyl-{3-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yloxy]-propyl}-amine 2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

  • 2-HYDROXYPYRIDINE-5-BORONIC ACID, PINACOL ESTER
  • 2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
  • 6-HYDROXY-PYRIDINE-3-BORONIC ACID, PINACOL ESTER
  • 6-HYDROXYPYRIDIN-3-YLBORONIC ACID, PINACOL ESTER
  • 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ol
  • 5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)-2(1H)-pyridinone
  • 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ol
  • 6-Hydroxypyridine-3-boronic acid, pinacol ester, 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ol
  • 2-Hydroxypyridin-5-ylboronic acid pinacol ester
  • 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-2-hydroxypyridine
  • 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2
  • 2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-
  • 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyridin-2-one
  • 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one
  • 2(1H)-Pyridinone, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
  • 2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE ISO 9001：2015 REACH
  • 2-Hydroxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyr...
  • 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyridin-2-one - [T16295]
  • 1054483-78-1
  • C11H18BNO4
  • Boronate Esters
  • Boronic Acids and Derivatives
  • Chemical Synthesis
  • Heteroaryl Boronate Esters
  • Organometallic Reagents