ChemicalBook > CAS DataBase List > 6-BROMO-4-CHLOROQUINOLINE

6-BROMO-4-CHLOROQUINOLINE

Product Name: 6-BROMO-4-CHLOROQUINOLINE
CAS No.: 65340-70-7
Chemical Name: 6-BROMO-4-CHLOROQUINOLINE
Synonyms: BUTTPARK 23\09-04;6-BROMO-4-CHLOROQUINOLINE;4-CHLORO-6-BROMOQUINOLINE;Quinoline,6-bromo-4-chloro-;4--6-broMinechlorinequinoline;6-Bromo-4-chloroquinoline ,97%;6-Bromo-4-chloroquinoline ,98%;6-Bromo-4-chloro-1-azanaphthalene;6-BROMO-4-CHLOROQUINOLINE ISO 9001：2015 REACH
CBNumber: CB3182154
Molecular Formula: C9H5BrClN
Formula Weight: 242.5
MOL File: 65340-70-7.mol

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6-BROMO-4-CHLOROQUINOLINE Property

Melting point:: 110-112℃
Boiling point:: 314.6±22.0 °C(Predicted)
Density: 1.673±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Toluene
form: solid
pka: 2.76±0.16(Predicted)
Appearance: White to light yellow Solid
InChI: InChI=1S/C9H5BrClN/c10-6-1-2-9-7(5-6)8(11)3-4-12-9/h1-5H
InChIKey: KJILYZMXTLCPDQ-UHFFFAOYSA-N
SMILES: N1C2C(=CC(Br)=CC=2)C(Cl)=CC=1

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Safety

Hazard Codes: T
Risk Statements: 25-20/22
Safety Statements: 45-36/37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29334900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: JRD0187
Product name: 6-Bromo-4-chloroquinoline
Purity: Aldrich
Packaging: 1g
Price: $216
Updated: 2025/07/31

TCI Chemical

Product number: B5166
Product name: 6-Bromo-4-chloroquinoline
Purity: >98.0%(GC)
Packaging: 1g
Price: $65
Updated: 2025/07/31

TCI Chemical

Product number: B5166
Product name: 6-Bromo-4-chloroquinoline
Purity: >98.0%(GC)
Packaging: 5g
Price: $187
Updated: 2025/07/31

TRC

Product number: B684808
Product name: 6-Bromo-4-chloroquinoline
Packaging: 500mg
Price: $65
Updated: 2021/12/16

TRC

Product number: B684808
Product name: 6-Bromo-4-chloroquinoline
Packaging: 100mg
Price: $45
Updated: 2021/12/16

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6-BROMO-4-CHLOROQUINOLINE Chemical Properties,Usage,Production

Chemical Properties

Light yellow to yellow powder

Uses

6-Bromo-4-chloroquinoline belongs to the class of heterocyclic compounds and has been used in the synthesis of other compounds, such as pharmaceuticals.

Synthesis

145369-94-4

65340-70-7

4.1.8 Synthesis of 6-bromo-4-chloroquinoline (11) To a 100 mL round bottom flask were sequentially added 6-bromo-4-hydroxyquinoline (10) (3.0 g, 13.45 mmol), phosphorus trichloride (20 mL) and N,N-dimethylformamide (0.5 mL). The reaction mixture was heated to reflux and stirred for 6 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was slowly poured into ice water (100 mL) and stirring was continued for 1 hour. Subsequently, the pH of the mixture was adjusted with saturated aqueous sodium bicarbonate solution to 8. The reaction mixture was extracted with ethyl acetate, the organic phases were combined and dried with anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to give the title compound 6-bromo-4-chloroquinoline (11) (2.75 g, 11.36 mmol, 84% yield) as a white solid. 1H NMR (500 MHz, DMSO-d6) δ 8.87 (d, J = 4.5 Hz, 1H, Ar-H), 8.32 (d, J = 2.0 Hz, 1H, Ar-H), 8.03 (d, J = 9.0 Hz, 1H, Ar-H), 7.99 (dd, J = 9.0, 2.0 Hz, 1H, Ar-H), 7.82 (d, J = 4.5 Hz, 1H, Ar-H). ESI-MS: m/z = 242 [M + H]+.

References

[1] Patent: US2006/63805, 2006, A1. Location in patent: Page/Page column 9
[2] ChemMedChem, 2015, vol. 10, # 5, p. 836 - 849
[3] Patent: US2015/320727, 2015, A1. Location in patent: Paragraph 0557; 0558
[4] European Journal of Medicinal Chemistry, 2015, vol. 99, p. 36 - 50
[5] Patent: WO2006/132739, 2006, A2. Location in patent: Page/Page column 48

6-BROMO-4-CHLOROQUINOLINE Preparation Products And Raw materials

Raw materials

Hexane Biphenyl N,N-Dimethylformamide Acetone Sodium sulfate Diphenyl ether Trimethoxymethane 2-methylpentane Diethyl ether Ethyl acetate Sodium bicarbonate 2,2-Dimethyl-1,3-dioxane-4,6-dione Thionyl chloride PETROLEUM ETHER 4-Bromoaniline

Preparation Products

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View Lastest Price from 6-BROMO-4-CHLOROQUINOLINE manufacturers

Hinova Pharma

Product: 6-BROMO-4-CHLOROQUINOLINE 65340-70-7
Price: US $3000.00-500.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000kg
Release date: 2025-07-10

Shaanxi Dideu New Materials Co. Ltd

Product: 6-BROMO-4-CHLOROQUINOLINE 65340-70-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-07-05

Hebei Zhanyao Biotechnology Co. Ltd

Product: 6-BROMO-4-CHLOROQUINOLINE 65340-70-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-10-14

65340-70-7, 6-BROMO-4-CHLOROQUINOLINERelated Search:

6-bromo-4-methylquinazoline 3-Quinolinecarbonitrile, 7-broMo-4-hydroxy- 6-BROMO-4-CHLORO-QUINOLINE-3-CARBONITRILE 6-BROMO-4-CHLORO-2-METHYL-QUINAZOLINE 6-Bromoquinazolin-4-ol 6-BROMO-4-HYDROXYQUINOLINE QUINAZOLINE, 6-BROMO-4-CHLORO-2-(TRIFLUOROMETHYL)- 6-Bromo-4-methoxyquinoline 6-broMo-4-chloro-8-fluoroquinoline 6-BROMO-4-CHLORO-2-METHYLQUINOLINE 6-BROMO-4-CHLOROQUINOLINE 6-BROMO-4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE 2-bromo-6-chloroquinoline 4-BROMO-8-CHLOROQUINOLINE 6-Bromo-2-chloroquinoline-4-carboxylic acid,6-BROMO-2-CHLOROQUINOLINE-4-CARBOXYLIC ACID, 97 7-BROMO-4-CHLOROQUINOLINE 6-BROMO-2-CHLORO-QUINOLINE 4-Chloroquinoline

BUTTPARK 23\09-04

4-CHLORO-6-BROMOQUINOLINE

6-BROMO-4-CHLOROQUINOLINE

6-Bromo-4-chloroquinoline ,98%

6-Bromo-4-chloroquinoline ,97%

6-Bromo-4-chloro-1-azanaphthalene

4--6-broMinechlorinequinoline

Quinoline,6-bromo-4-chloro-

6-BROMO-4-CHLOROQUINOLINE ISO 9001：2015 REACH

65340-70-7