ChemicalBook > CAS DataBase List > A 769662

A 769662

Product Name
A 769662
CAS No.
844499-71-4
Chemical Name
A 769662
Synonyms
CS-18;A 769662;A-769622;A-769662, >=98%;A-769662/A769662;A-769662, 10 mM in DMSO;AMPK Signaling Activator XV;A 769662 ISO 9001：2015 REACH;A 769662, AMP-activated protein kinase activator;A 769662 (This product is unavailable in the U.S.)
CBNumber
CB31871930
Molecular Formula
C20H12N2O3S
Formula Weight
360.39
MOL File
844499-71-4.mol
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A 769662 Property

Melting point:
263 - 266oC
Boiling point:
630.1±55.0 °C(Predicted)
Density 
1.56
Flash point:
334.9℃
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 5 mg/ml),
form 
solid
pka
4.50±1.00(Predicted)
color 
Beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Safety

Safety Statements 
24/25
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2578
Product name
A-769662
Purity
≥98% (HPLC)
Packaging
5mg
Price
$99.75
Updated
2025/07/31
Sigma-Aldrich
Product number
SML2578
Product name
A-769662
Purity
≥98% (HPLC)
Packaging
25mg
Price
$385.7
Updated
2025/07/31
TCI Chemical
Product number
H1552
Product name
A 769662
Packaging
10MG
Price
$171
Updated
2025/07/31
TCI Chemical
Product number
H1552
Product name
A 769662
Packaging
50MG
Price
$513
Updated
2025/07/31
Cayman Chemical
Product number
11900
Product name
A-769662
Purity
≥98%
Packaging
5mg
Price
$69
Updated
2024/03/01
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A 769662 Chemical Properties,Usage,Production

Description

A-769662 is a small molecule thienopyridone that activates AMPK directly in cell-free assays (EC50 = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr172. A-769662 specifically activates β1 subunit-containing AMPK heterotrimers, and its effects are independent of kinases upstream of AMPK. A-769662 has been used to stimulate CYP450-mediated fatty acid oxidation, inhibit adipocyte differentiation, explore glucose uptake in skeletal muscle, and promote endothelial cell survival during metabolic stress.

Uses

A 769662 is an AMP-activated protein kinase (AMPK) activiator. A 769662 selectively activates cardiac AMPK heterotrimeric complexes contg. α2/β1-subunits.

Definition

ChEBI: 4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile is a member of biphenyls.

Biological Activity

Potent, reversible AMP-activated protein kinase (AMPK) activator (EC 50 = 0.8 μ M) that displays selectivity towards β 1 subunit-containing heterotrimers. Inhibits fatty acid synthesis (IC 50 = 3.2 μ M) and decreases plasma glucose and triglyceride levels in vivo .

storage

+4°C

References

[1] JOHN W SCOTT. Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.[J]. Chemistry & biology, 2008, 15 11: 1220-1230. DOI:10.1016/j.chembiol.2008.10.005
[2] BARBARA COOL. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome.[J]. Cell metabolism, 2006, 3 6: 403-416. DOI:10.1016/j.cmet.2006.05.005
[3] YI ZHOU. Inhibitory effects of A-769662, a novel activator of AMP-activated protein kinase, on 3T3-L1 adipogenesis.[J]. Biological & pharmaceutical bulletin, 2009, 32 6: 993-998. DOI:10.1248/bpb.32.993
[4] ALEJANDRO VAZQUEZ-MARTIN. Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells.[J]. Cell Cycle, 2012, 11 5: 974-989. DOI:10.4161/cc.11.5.19450
[5] SERGE DUCOMMUN. Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662.[J]. American journal of physiology. Endocrinology and metabolism, 2014, 306 6: E688-96. DOI:10.1152/ajpendo.00672.2013

A 769662 Preparation Products And Raw materials

Raw materials

Preparation Products

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A 769662 Suppliers

China 169 Europe 1 India 2 Japan 1 The Netherlands 1 United Kingdom 4 United States 22 Global 200
BOC Sciences
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021-58955995
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sales@medchemexpress.cn
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View Lastest Price from A 769662 manufacturers

Dideu Industries Group Limited
Product
A 769662 844499-71-4
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-09-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile 844499-71-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26

844499-71-4, A 769662Related Search:

5-[(2R)-2-([(2R)-2-(3-CHLOROPHENYL)-2-HYDROXYETHYL]AMINO)PROPYL]-1,3-BENZODIOXOLE-2,2-DICARBOXYLATE DISODIUM BIO Glibenclamide (3N-[(2S,3S)-2-AMINO-3-METHYL-PENTANOYL]-1,3-THIAZOLIDINE) HEMIFUMARATE 2,2-diphenyl-1-picrylhydrazyl RUETASOLV BP 4103 - MIXTURE OF ISOMERES ISOPROPYLBIPHENYLS. FOR FURTHER DETAILS PLEASE INQUIRE AT MARKETING CONTACTS. SPECIALITY CHEMICALS 4,4'-Biphenol 3-PHENYLPHENOL 4-Phenylphenol BML-275 PD 0325901 BIRB 796 (Doramapimod) AICAR Ibrutinib CHIR-99021

  • A 769662
  • 4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
  • 4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile
  • CS-18
  • 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile
  • Thieno[2,3-b]pyridine-5-carbonitrile, 6,7-dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-
  • A-769662/A769662
  • 4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitri
  • A-769622
  • A-769662 4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
  • A-769662, >=98%
  • 4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboni
  • 4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6
  • 4,6-dihydroxy-3-{2'-hydroxy-[1,1'-biphenyl]-4-yl}thi eno[2,3-b]pyridine-5-carbonitrile
  • A 769662 (This product is unavailable in the U.S.)
  • A 769662 ISO 9001：2015 REACH
  • 4-Hydroxy-3-(2’-hydroxy-4-biphenylyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
  • 4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
  • A 769662, AMP-activated protein kinase activator
  • A-769662, 10 mM in DMSO
  • AMPK Signaling Activator XV
  • 844499-71-4
  • C20H12N2O3S
  • Inhibitors
  • Akt
  • mTOR
  • PI3K
  • APIs
  • Signalling