ChemicalBook > CAS DataBase List > 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone

2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone

Product Name
2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone
CAS No.
204205-33-4
Chemical Name
2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone
Synonyms
2-broMo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-one;PL-02;Prasugrel IMP;Prasugrel IMpurity;Pragrel intermediate;Prasugrel Impurity 46;Prasugrel Intermediate 4;2-Bromo-2-(2-fluorophenyl);Chemical intermediate for Prasugrel;Prasugrel alpha-Bromo 2-Fluoro Impurity
CBNumber
CB31872230
Molecular Formula
C11H10BrFO
Formula Weight
257.1
MOL File
204205-33-4.mol
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2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone Property

Boiling point:
293.0±25.0 °C(Predicted)
Density 
1.574±0.06 g/cm3(Predicted)
Flash point:
131°
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Sparingly), Ethyl Acetate (Slightly)
form 
Oil to Low-Melting Solid
form 
Oil to Low-Melting Solid
color 
Yellow to Light Brown
optical activity
0.0900°(C=1g/100mL, CHCL3, 20°C, 589nm)
CAS DataBase Reference
204205-33-4(CAS DataBase Reference)
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Safety

HS Code 
2914.79.4000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B6031
Product name
2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone
Packaging
1G
Price
$42
Updated
2025/07/31
TCI Chemical
Product number
B6031
Product name
2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone
Packaging
5G
Price
$146
Updated
2025/07/31
TRC
Product number
B688795
Product name
2-​Bromo-​2-​(2-​fluorophenyl)​-​1-​cyclopropylethanone(90%purity)
Packaging
5g
Price
$675
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB36572
Product name
2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone
Packaging
2g
Price
$400
Updated
2021/12/16
SynQuest Laboratories
Product number
2717-B-04
Product name
2-Bromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-one
Purity
96%
Packaging
250mg
Price
$491
Updated
2021/12/16
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2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone Chemical Properties,Usage,Production

Uses

2-?Bromo-?2-?(2-?fluorophenyl)?-?1-?cyclopropylethanone is a reagent used in the synthesis of potent anti-oxidant agents.

Synthesis

150322-73-9

204205-33-4

General procedure for the synthesis of 2-bromo-2-(2-fluorophenyl)-1-cyclopropylethanone from 1-cyclopropyl-2-(2-fluorophenyl)ethanone: 1-cyclopropyl-2-(2-fluorophenyl)ethanone (17.8 g, 100 mmol), iodine monobromide (62 g, 300 mmol), and 1-butyl-3-methylimidazolium bromide (8.7 g, 40 mmol) were dissolved in 150 mL of anhydrous tetrahydrofuran. The reaction was stirred at 40 °C for 4 hours. After completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched by the addition of ice water. The reaction mixture was extracted with ethyl acetate and the organic phase was washed with saturated sodium bisulfite solution. The organic phase was concentrated and purified by recrystallization from ethanol to give 2-bromo-2-(2-fluorophenyl)-1-cyclopropylethanone (24.5 g, 95.3% yield, 99.73% purity).

References

[1] Patent: CN105884793, 2016, A. Location in patent: Paragraph 0033; 0034; 0035
[2] Patent: WO2013/14295, 2013, A1. Location in patent: Page/Page column 19-20
[3] Patent: WO2009/122440, 2009, A1. Location in patent: Page/Page column 31
[4] Patent: CN105884599, 2016, A. Location in patent: Paragraph 0025; 0062-0064
[5] Patent: CN104418718, 2018, B. Location in patent: Paragraph 0040; 0044; 0047; 0048; 0052; 0056

2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone Suppliers

Americas 1 China 219 Europe 1 India 19 Japan 1 United Kingdom 1 United States 10 Global 252
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone manufacturers

ZHUHAI HRD PHARMACEUTICAL CO., LTD.
Product
2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone 204205-33-4
Price
US $0.00/KG Ton
Min. Order
1KG Ton
Purity
93%+
Supply Ability
2 tons/month
Release date
2022-10-09
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone 204205-33-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone 204205-33-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

204205-33-4, 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanoneRelated Search:

5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride 3-Methyl-2-butanone Heptafluoroisopropyl iodide 2-Bromopropane Cyclopropyl methyl ketone Cyclopropyl bromide N-Methyl-2-pyrrolidone Allyl bromide Propargyl bromide Cyclopropyl 4-Fluorobenzyl Ketone 2-BroMo-1-cyclopropyl-2-(3-fluorophenyl)ethanone (3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile 7-(4-Hydroxybutoxy-4,4-d2)-2(1H)-quinolinone (1R,3S)-1-(1,3-Benzodioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester BENZOOXAZOL-2-YLAMINE Etoricoxib IMpurity Trelagliptin IMpurity pranoprofen

  • Prasugrel Intermediate 4
  • 2-Bromo-2-(2-fluorophenyl)
  • Ethanone, 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)-
  • 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone
  • Cylopropylcarbonyl-2-flurobenzyl bromide
  • 2-Bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone
  • Chemical intermediate for Prasugrel
  • 2-broMo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-one
  • Prasugrel IMpurity
  • PL-02
  • α - cyclopropyl carbonyl -2- fluorine benzyl bromide
  • Prasugrel IMP
  • 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone in stock Factory
  • 2-fluoro-α-cyclopropyl carbonyl benzyl bromide
  • 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone (90% purity)
  • Prasugrel alpha-Bromo 2-Fluoro Impurity
  • Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone
  • Cyclopropylcarbonyl-2-fluorobenzyl bromide
  • 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanoneQ: What is 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone Q: What is the CAS Number of 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone Q: What is the storage condition of 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone Q: What are the applications of 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone
  • 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone 204205-33-4
  • α-(Cyclopropylcarbonyl)-2-fluorobenzyl bromide
  • Prasugrel Impurity 46
  • Pragrel intermediate
  • Prasugrel Impurity 12 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-one
  • 2-Bromo-2-(2-fluorophenyl)cyclopropanone
  • 204205-33-4
  • C11H10BrFO