ChemicalBook > CAS DataBase List > 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone
2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone
- Product Name
- 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone
- CAS No.
- 204205-33-4
- Chemical Name
- 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone
- Synonyms
- 2-broMo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-one;PL-02;Prasugrel IMP;Prasugrel IMpurity;Pragrel intermediate;Prasugrel Impurity 46;Prasugrel Intermediate 4;2-Bromo-2-(2-fluorophenyl);Chemical intermediate for Prasugrel;Prasugrel alpha-Bromo 2-Fluoro Impurity
- CBNumber
- CB31872230
- Molecular Formula
- C11H10BrFO
- Formula Weight
- 257.1
- MOL File
- 204205-33-4.mol
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2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone Property
- Boiling point:
- 293.0±25.0 °C(Predicted)
- Density
- 1.574±0.06 g/cm3(Predicted)
- Flash point:
- 131°
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Sparingly), Ethyl Acetate (Slightly)
- form
- Oil to Low-Melting Solid
- form
- Oil to Low-Melting Solid
- color
- Yellow to Light Brown
- optical activity
- 0.0900°(C=1g/100mL, CHCL3, 20°C, 589nm)
- CAS DataBase Reference
- 204205-33-4(CAS DataBase Reference)
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Safety
- HS Code
- 2914.79.4000
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- B6031
- Product name
- 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone
- Packaging
- 1G
- Price
- $42
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B6031
- Product name
- 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone
- Packaging
- 5G
- Price
- $146
- Updated
- 2025/07/31
TRC
- Product number
- B688795
- Product name
- 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone(90%purity)
- Packaging
- 5g
- Price
- $675
- Updated
- 2021/12/16
AK Scientific
- Product number
- B633
- Product name
- 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone
- Packaging
- 1g
- Price
- $98
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB36572
- Product name
- 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone
- Packaging
- 500mg
- Price
- $140
- Updated
- 2021/12/16
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2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone Chemical Properties,Usage,Production
Uses
2-?Bromo-?2-?(2-?fluorophenyl)?-?1-?cyclopropylethanone is a reagent used in the synthesis of potent anti-oxidant agents.
Synthesis
150322-73-9
204205-33-4
General procedure for the synthesis of 2-bromo-2-(2-fluorophenyl)-1-cyclopropylethanone from 1-cyclopropyl-2-(2-fluorophenyl)ethanone: 1-cyclopropyl-2-(2-fluorophenyl)ethanone (17.8 g, 100 mmol), iodine monobromide (62 g, 300 mmol), and 1-butyl-3-methylimidazolium bromide (8.7 g, 40 mmol) were dissolved in 150 mL of anhydrous tetrahydrofuran. The reaction was stirred at 40 °C for 4 hours. After completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched by the addition of ice water. The reaction mixture was extracted with ethyl acetate and the organic phase was washed with saturated sodium bisulfite solution. The organic phase was concentrated and purified by recrystallization from ethanol to give 2-bromo-2-(2-fluorophenyl)-1-cyclopropylethanone (24.5 g, 95.3% yield, 99.73% purity).
References
[1] Patent: CN105884793, 2016, A. Location in patent: Paragraph 0033; 0034; 0035
[2] Patent: WO2013/14295, 2013, A1. Location in patent: Page/Page column 19-20
[3] Patent: WO2009/122440, 2009, A1. Location in patent: Page/Page column 31
[4] Patent: CN105884599, 2016, A. Location in patent: Paragraph 0025; 0062-0064
[5] Patent: CN104418718, 2018, B. Location in patent: Paragraph 0040; 0044; 0047; 0048; 0052; 0056
2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone manufacturers
ZHUHAI HRD PHARMACEUTICAL CO., LTD.
- Product
- 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone 204205-33-4
- Price
- US $0.00/KG Ton
- Min. Order
- 1KG Ton
- Purity
- 93%+
- Supply Ability
- 2 tons/month
- Release date
- 2022-10-09
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone 204205-33-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 2-Bromo-2-(2-fluorophenyl)-1-cyclopropylethanone 204205-33-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08
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