ChemicalBook > CAS DataBase List > 1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE

1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE

Product Name
1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE
CAS No.
168986-60-5
Chemical Name
1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE
Synonyms
RS67333HCl;RS 67333 hydrochlori;RS 67333 HYDROCHLORIDE;RS 67333 hydrochloride >=98% (HPLC);RS 67333 hydrochloride, 10 mM in DMSO;1-(4-AMino-5-chloro-2-Methoxyphenyl)-3-(1-butylpiperidin-4-yl)propan-1-one hydrochloride;1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE;1-Propanone, 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)-, hydrochloride (1:1)
CBNumber
CB3187740
Molecular Formula
C19H30Cl2N2O2
Formula Weight
389.36
MOL File
168986-60-5.mol
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1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Property

storage temp. 
Store at RT
form 
Powder
color 
Light yellow to yellow
Water Solubility 
Soluble to 25 mM in water with gentle warming
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1882
Product name
RS 67333 hydrochloride
Purity
≥98% (HPLC)
Packaging
5MG
Price
$108
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1882
Product name
RS 67333 hydrochloride
Purity
≥98% (HPLC)
Packaging
25MG
Price
$436
Updated
2025/07/31
TRC
Product number
R701025
Product name
RS67333Hydrochloride
Packaging
50mg
Price
$610
Updated
2021/12/16
ApexBio Technology
Product number
B5041
Product name
1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butylpiperidin-4-yl)propan-1-one hydrochloride
Packaging
50mg
Price
$929
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0006965
Product name
RS -67333
Purity
95.00%
Packaging
5MG
Price
$504.82
Updated
2021/12/16
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1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

RS 67333 Hydrochloride is a 5-HT4 receptor agonist.

Biological Activity

A potent and highly selective 5-HT 4 partial agonist, with pK i values of 8.7 at 5-HT 4 sites in guinea pig striatum and > 6 at various other receptors, including 5-HT 1A , 1D , 2A , 2C , D 1 , D 2 and M 1-3 . Active in vivo , with an intrinsic activity relative to 5-HT of 0.5.

Biochem/physiol Actions

RS 67333 is a selective, high affinity (pKi = 8.7 for the 5-HT4 binding site in guinea-pig striatum) partial agonist toward 5-HT4 receptor that relaxes carbachol-contracted rat oesphageal muscularis mucosae ex vivo (pEC50/%reversal = 8.7/50 with RS 67333 vs. 8.2/100 with 5-HT) and induces tachycardia (tachyarrhythmia) of anaesthetized micropigs in vivo (ED50 via i.p. in μg/kg over max heart rate increase in beats/min = 4.9/35 with RS 67333 vs. 3.2/95 with 5-HT). RS 67333 is also reported to show high affinity for sigma receptors (pKi = 8.9/σ1 and 8.0/σ2), while exhibiting much reduced affinity toward a panel of other receptors, including 5-HT1A, 5-HT2A, 5-HT2C, 5-HT3 (pKi <6.4), muscarinic receptors (pKi = 5.2/M1 & 5.3/M2), and adrenoceptors (pKi <6.7 for α1A, α1B, α2A, α2B, β1, β2).

IC 50

5-HT4 Receptor: 8.7 (pKi)

1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Suppliers

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168986-60-5, 1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDERelated Search:

Poly(hexamethylenebiguanide)hydrochloride Triethylamine hydrochloride 1-(4-Amino-2-hydroxy-phenyl)-propan-1-one 2-Chloro-5-methoxyaniline P-HEXYLANILINE HYDROCHLORIDE 1-(4-AMINO-3-CHLORO-PHENYL)-PROPAN-1-ONE 4-(3-PHENYL-PROPYL)-PIPERIDINE HCL 1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE 1-(4-AMINO-3-CHLORO-PHENYL)-ETHANONE 4-aminohexanoylphenone

  • 1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE
  • RS 67333 HYDROCHLORIDE
  • RS67333HCl
  • 1-(4-AMino-5-chloro-2-Methoxyphenyl)-3-(1-butylpiperidin-4-yl)propan-1-one hydrochloride
  • 1-Propanone, 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)-, hydrochloride (1:1)
  • RS 67333 hydrochloride >=98% (HPLC)
  • RS 67333 hydrochlori
  • RS 67333 hydrochloride, 10 mM in DMSO
  • 168986-60-5
  • C19H30Cl2N2O2
  • C19H29ClN2O2HCl