1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE
- Product Name
- 1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE
- CAS No.
- 168986-60-5
- Chemical Name
- 1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE
- Synonyms
- RS67333HCl;RS 67333 hydrochlori;RS 67333 HYDROCHLORIDE;RS 67333 hydrochloride >=98% (HPLC);RS 67333 hydrochloride, 10 mM in DMSO;1-(4-AMino-5-chloro-2-Methoxyphenyl)-3-(1-butylpiperidin-4-yl)propan-1-one hydrochloride;1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE;1-Propanone, 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)-, hydrochloride (1:1)
- CBNumber
- CB3187740
- Molecular Formula
- C19H30Cl2N2O2
- Formula Weight
- 389.36
- MOL File
- 168986-60-5.mol
1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Property
- storage temp.
- Store at RT
- form
- Powder
- color
- Light yellow to yellow
- Water Solubility
- Soluble to 25 mM in water with gentle warming
N-Bromosuccinimide Price
- Product number
- SML1882
- Product name
- RS 67333 hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $105
- Updated
- 2024/03/01
- Product number
- SML1882
- Product name
- RS 67333 hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $424
- Updated
- 2024/03/01
- Product number
- R701025
- Product name
- RS67333Hydrochloride
- Packaging
- 50mg
- Price
- $610
- Updated
- 2021/12/16
- Product number
- B5041
- Product name
- 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butylpiperidin-4-yl)propan-1-one hydrochloride
- Packaging
- 50mg
- Price
- $929
- Updated
- 2021/12/16
- Product number
- API0006965
- Product name
- RS -67333
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.82
- Updated
- 2021/12/16
1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
RS 67333 Hydrochloride is a 5-HT4 receptor agonist.
Biological Activity
A potent and highly selective 5-HT 4 partial agonist, with pK i values of 8.7 at 5-HT 4 sites in guinea pig striatum and > 6 at various other receptors, including 5-HT 1A , 1D , 2A , 2C , D 1 , D 2 and M 1-3 . Active in vivo , with an intrinsic activity relative to 5-HT of 0.5.
Biochem/physiol Actions
RS 67333 is a selective, high affinity (pKi = 8.7 for the 5-HT4 binding site in guinea-pig striatum) partial agonist toward 5-HT4 receptor that relaxes carbachol-contracted rat oesphageal muscularis mucosae ex vivo (pEC50/%reversal = 8.7/50 with RS 67333 vs. 8.2/100 with 5-HT) and induces tachycardia (tachyarrhythmia) of anaesthetized micropigs in vivo (ED50 via i.p. in μg/kg over max heart rate increase in beats/min = 4.9/35 with RS 67333 vs. 3.2/95 with 5-HT). RS 67333 is also reported to show high affinity for sigma receptors (pKi = 8.9/σ1 and 8.0/σ2), while exhibiting much reduced affinity toward a panel of other receptors, including 5-HT1A, 5-HT2A, 5-HT2C, 5-HT3 (pKi <6.4), muscarinic receptors (pKi = 5.2/M1 & 5.3/M2), and adrenoceptors (pKi <6.7 for α1A, α1B, α2A, α2B, β1, β2).
1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Suppliers
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