ChemicalBook > CAS DataBase List > METHYL ISOXAZOLE-5-CARBOXYLATE

METHYL ISOXAZOLE-5-CARBOXYLATE

Product Name
METHYL ISOXAZOLE-5-CARBOXYLATE
CAS No.
15055-81-9
Chemical Name
METHYL ISOXAZOLE-5-CARBOXYLATE
Synonyms
AKOS PAO-1372;methyl 5-isoxazolcarboxylate;methyl oxazole-5-carboxylate;METHYL ISOXAZOLE-5-CARBOXYLATE;methyl 1,2-oxazole-5-carboxylate;5-Isoxazolecarboxylic acid, Methyl ester;ISOXAZOLE-5-CARBOXYLIC ACID METHYL ESTER;methyl isoxazole-5-carboxylate - [M83091];Isoxazole-5-carboxylic acid ethyl ester;Methyl 1,2-oxazole-5-carboxylate, 5-(Methoxycarbonyl)isozazole
CBNumber
CB3191387
Molecular Formula
C5H5NO3
Formula Weight
127.1
MOL File
15055-81-9.mol
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METHYL ISOXAZOLE-5-CARBOXYLATE Property

Melting point:
48-51
Boiling point:
203.9±13.0 °C(Predicted)
Density 
1.229±0.06 g/cm3(Predicted)
storage temp. 
Store at room temperature
pka
-3.88±0.50(Predicted)
Appearance
Off-white to light brown Solid
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Safety

Hazard Codes 
Xi
Safety Statements 
22-24/25
Hazard Note 
Irritant
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
I918115
Product name
5-IsoxazolecarboxylicAcidMethylEster
Packaging
1g
Price
$140
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-1-72
Product name
Methyl isoxazole-5-carboxylate
Packaging
1g
Price
$104
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-1-72
Product name
Methyl isoxazole-5-carboxylate
Packaging
5G
Price
$336
Updated
2021/12/16
AK Scientific
Product number
W3292
Product name
Methylisoxazole-5-carboxylate
Packaging
25g
Price
$1171
Updated
2021/12/16
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METHYL ISOXAZOLE-5-CARBOXYLATE Chemical Properties,Usage,Production

Uses

5-Isoxazolecarboxylic Acid Methyl Ester is used as a reagent in the synthesis of pyridine derivatives as integrase inhibitors and antiviral agents. 5-Isoxazolecarboxylic Acid Methyl Ester is also a useful synthetic intermediate in the preparation of pyrazolopyrimidine derivatives useful in the prevention and treatment of cancer.

Synthesis

21169-71-1

74-88-4

15055-81-9

A mixture of isoxazole-5-carboxylic acid (2.5 g, 22.1 mmol), sodium bicarbonate (5.57 g, 66.32 mmol) and iodomethane (8.26 mL, 132.65 mmol) in N,N-dimethylformamide (DMF, 30 mL) was stirred and reacted for 19 hr at 25 °C. After completion of the reaction, the mixture was diluted with deionized water (30 mL) and extracted with ether (2 × 50 mL). The combined organic layers were washed with saturated saline, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by a Biotage fast chromatography system (40 m column) with the eluent of ethyl acetate-hexane (1:2, v/v), followed by switching to pure ethyl acetate, resulting in methyl isoxazole-5-carboxylate as an amorphous solid (1.2 g, 42.7% yield). Mass spectrum (+ESI): m/z 128 [M+H]+.

References

[1] Patent: US2007/219186, 2007, A1. Location in patent: Page/Page column 51

METHYL ISOXAZOLE-5-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL ISOXAZOLE-5-CARBOXYLATE Suppliers

Austria 1 China 70 Germany 3 India 2 Slovakia 1 Switzerland 2 United Kingdom 4 United States 7 Global 90
MOLEKULA Ltd.
Tel
--
Fax
--
Email
kevinbanks@molekula.com
Country
United Kingdom
ProdList
6140
Advantage
66
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United Kingdom
ProdList
6401
Advantage
74
VWR International
Tel
--
Fax
--
Email
solutions@vwr.com
Country
United Kingdom
ProdList
6548
Advantage
82
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View Lastest Price from METHYL ISOXAZOLE-5-CARBOXYLATE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
METHYL ISOXAZOLE-5-CARBOXYLATE 15055-81-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-18
Career Henan Chemical Co
Product
METHYL ISOXAZOLE-5-CARBOXYLATE 15055-81-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200kgs
Release date
2020-01-28

15055-81-9, METHYL ISOXAZOLE-5-CARBOXYLATERelated Search:

Isoxazole 5-Isoxazolecarboxylicacid,ethylester(9CI) ISOXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER Isoxazol-4-ylmethanamine oxalate ISOXAFLUTOLE ISOXAZOLO[5,4-B]PYRIDIN-3-YLAMINE ISOXAZOLE-5-CARBOXYLIC ACID ISOXAZOLIDIN-3-ONE 1,2-oxazol-3-ylMethanaMine hydrochloride 3-AMINOISOXAZOLO[4,5-B]PYRAZINE Isoxazole-4-boronicacid C-ISOXAZOL-5-YL-METHYLAMINE HYDROCHLORIDE 4-Aminoisoxazole C-ISOXAZOL-4-YL-METHYLAMINE HYDROCHLORIDE ISOXAZOLE-3-CARBONITRILE Isoxazolo[5,4-c]pyridin-3-amine (9CI) isoxazol-3-yl-acetic acid 4-HYDROXYMETHYL-ISOXAZOLE

  • AKOS PAO-1372
  • ISOXAZOLE-5-CARBOXYLIC ACID METHYL ESTER
  • METHYL ISOXAZOLE-5-CARBOXYLATE
  • Isoxazole-5-carboxylic acid ethyl ester
  • methyl oxazole-5-carboxylate
  • 5-Isoxazolecarboxylic acid, Methyl ester
  • Methyl 1,2-oxazole-5-carboxylate, 5-(Methoxycarbonyl)isozazole
  • methyl 1,2-oxazole-5-carboxylate
  • methyl 5-isoxazolcarboxylate
  • methyl isoxazole-5-carboxylate - [M83091]
  • 15055-81-9