ChemicalBook > CAS DataBase List > Dequalinium chloride

Dequalinium chloride

Product Name
Dequalinium chloride
CAS No.
522-51-0
Chemical Name
Dequalinium chloride
Synonyms
DECA;Dequalinium chloride for performance test CRS;dequadin;Dequalinum;dequafungan;DEQUALINIUM DICHLORIDE;Dequalinium chloride CRS;DEQUALINIUM CHLORIDE HYDRATE;efisol;evazol
CBNumber
CB3193093
Molecular Formula
C30H40Cl2N4
Formula Weight
527.57
MOL File
522-51-0.mol
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Dequalinium chloride Property

Melting point:
≥300 °C(lit.)
storage temp. 
2-8°C
solubility 
Slightly soluble in water and in ethanol (96 per cent).
form 
Solid
color 
Beige
Merck 
13,2930
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
InChIKey
LTNZEXKYNRNOGT-UHFFFAOYSA-N
CAS DataBase Reference
522-51-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
RTECS 
VA0700000
F 
8
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1300
Product name
Dequalinium chloride
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500mg
Price
$132
Updated
2024/03/01
Sigma-Aldrich
Product number
D0430000
Product name
Dequalinium chloride
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
d0430000
Price
$220
Updated
2024/03/01
Cayman Chemical
Product number
17557
Product name
Dequalinium (chloride)
Purity
≥98%
Packaging
250mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17557
Product name
Dequalinium (chloride)
Purity
≥98%
Packaging
500mg
Price
$61
Updated
2024/03/01
Sigma-Aldrich
Product number
D0431000
Product name
Dequalinium chloride for performance test
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
d0431000
Price
$149
Updated
2023/01/07
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Dequalinium chloride Chemical Properties,Usage,Production

Description

Dequalinium Chloride is a a potent and selective non-peptide blocker of the apamin-sensitive small conductance Ca2+-activated K+ channel (IC50 = 1.1 mM).

Chemical Properties

White or yellowish-white powder, hygroscopic.

Originator

Dequsan,Sante

Uses

Dequalinium Chloride is a quaternary ammonium cation and the active ingredient in various medications including antiseptic and anti-malarial agents.

Definition

ChEBI: Dequalinium chloride is an organic chloride salt that is the dichloride salt of dequalinium. It has a role as an antiseptic drug, a mitochondrial NADH:ubiquinone reductase inhibitor, an antifungal agent and an antineoplastic agent. It contains a dequalinium.

Manufacturing Process

a) 15 g of 4-aminoquinaldine, 15 g of decamethylene diiodide and 200 ml of methyl ethyl ketone were refluxed together for 400 hours. The mixture was allowed to cool, the precipitate filtered off, washed with methyl ethyl ketone, and 1,1'-decamethylenebis(4-aminoquinaldinium chloride) recrystallized from ethyl alcohol containing a little methyl alcohol.
b) 160 g of 4-aminoquinaldine, 174 g of decamethylene diiodide and 1,500 ml of methyl isobutyl carbinol were heated together at 120°C for 90 hours. The mixture was allowed to cool, the precipitate filtered off, washed with methyl ethyl ketone and 1,1'-decamethylenebis(4-aminoquinaldinium chloride) recrystallized from ethyl alcohol containing a little methyl alcohol.
b) 160 g of 4-aminoquinaldine, 174 g of decamethylene diiodide and 1,500 ml of methyl isobutyl carbinol were heated together at 120°C for 90 hours. The mixture was allowed to cool, the precipitate filtered off, washed with methyl ethyl ketone and 1,1'-decamethylenebis(4-aminoquinaldinium chloride) recrystallized from ethyl alcohol containing a little methyl alcohol.

brand name

Decabis;Dequacaine;Dequafungan;Dequin;Faringina;Gargilon;Grocreme;Labosept;Maltyl;Phylletten;Soor-gel;Sorot;Tetesept.

Therapeutic Function

Antiseptic, Antifungal

World Health Organization (WHO)

Skin reactions to dequalinium chloride, including necrotic lesions, have been reported. It remains available as a mouth and throat disinfectant in many countries.

General Description

Dequalinium Chloride is a topical bacteriostat that is available as various salts. It is used in wound dressings and mouth infections and may also have antifungal action, but may cause skin ulceration.

Biological Activity

Dequalinium is a quaternary ammonium cation with diverse biological activities. It has antifungal activity against C. albicans, C. glabrata, and C. krusei (MICs = 0.5-2, 64-256, and 128 μg/ml, respectively), antitrichomonal activity against T. vaginalis (MICs = 28.8-230.4 μg/ml), and antibacterial activity against a panel of aerobic and facultative anaerobic bacteria (MICs = 0.25-256 μg/ml). Dequalinium inhibits apamin binding to, and net potassium loss mediated by, SKCa channels in guinea pig hepatocytes stimulated by angiotensin II (Item No. 17150). In vivo, dequalinium (1-10 mg/kg) inhibits primary and recurrent tumor growth in a W163 rat colon carcinoma isograft model.

References

1) Miyata?et al.?(2014),?Pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1; Proc. Natl. Acad. Sci. USA?111?14406
2) Frey Tirri?et al.?(2011),?Antimicrobial topical agents used in the vagina; Curr. Probl. Dermatol.?40?36
3) Castle?et al.?(1993),?Dequalinium: a potent inhibitor of apamin-sensitive K+ channels in hepatocytes and of nicotinic responses in skeletal muscle; Eur. J. Pharmacol.?236?201
4) Orzaez?et al.?(2011),?Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain; Apoptosis?16?460

Dequalinium chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Dequalinium chloride Suppliers

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View Lastest Price from Dequalinium chloride manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Dequalinium chloride 522-51-0
Price
US $100.00-75.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000Ton
Release date
2024-08-13
Hebei Weibang Biotechnology Co., Ltd
Product
Dequalinium chloride 522-51-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-12
Hebei Mojin Biotechnology Co., Ltd
Product
Dequalinium chloride 522-51-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-25

522-51-0, Dequalinium chlorideRelated Search:

Sulfuryl chloride Calcium chloride Sodium chloride Bensulfuron methyl Ammonium chloride Ferric chloride Methyl acrylate Potassium chloride Polyvinyl chloride Cobalt chloride Methylparaben Trospium chloride Choline chloride Cetylpyridinium chloride Kresoxim-methyl Benzalkonium chloride Thiophanate-methyl BENZALKONIUM CHLORIDE

  • 1,1'-DECAMETHYLENEBIS(4-AMINOQUINALDINIUM CHLORIDE)
  • 1,1'-DECAMETHYLENEBIS(4-AMINOQUINALDINIUM) DICHLORIDE
  • 1,1'-(1,10-DECANEDIYL)BIS(4-AMINO-2-METHYLQUINOLINIUM) DICHLORIDE
  • DEQUALINIUM CHLORIDE
  • DEQUALINIUM DICHLORIDE
  • DECA
  • dequadinchloride
  • dequafungan
  • dequavagyn
  • dequavet
  • efisol
  • eriosept
  • evazol
  • 1,1'-[1,10-Decanediyl] bis[4-amino-2-methylquinolinium chloride]
  • Dequalinum
  • Quinolinium, 1,1-(1,10-decanediyl)bis4-amino-2-methyl-, dichloride
  • QUINALDINIUM,1,1'-DECAMETHYLENEBIS(4-AMINO-,DICHLORIDE
  • 1,1μ-Decamethylenebis(4-aminoquinaldinium) dichloride hydrate
  • 1,1'-(1,10-Decanediyl)bis(4-amino-2-methylquinolinium)·2chloride
  • 1,1'-(Decane-1,10-diyl)bis(4-amino-2-methylquinoline-1-ium)·2chloride
  • 1,1'-Decamethylenebis(2-methyl-4-aminoquinolinium)·dichloride
  • BADQ-10
  • DequaliniuM (graMs of bacteria May be)
  • QuinoliniuM,1,1'-(1,10-decanediyl)bis[4-aMino-2-Methyl-, chloride (1:2)
  • 1,1'-(decane-1,10-diyl)bis(4-aMino-2-Methylquinolin-1-iuM) chloride
  • 1-[10-(4-amino-2-methyl-1-quinolin-1-iumyl)decyl]-2-methyl-4-quinolin-1-iumamine dichloride hydrate
  • 1,1’-decamethylenebis(4-amino-quinaldiniudichloride
  • 1,10-decamethylene-bis(4-aminoquinaldiniumchloride)
  • baqd10
  • decamethylenebis(4-aminoquinaldiniumchloride)
  • decamine(pharmaceutical)
  • dekadin
  • dekamin
  • dequadin
  • grocreme
  • labosept
  • optipect
  • phylletten
  • polycidine
  • Dequalinum Chloride
  • DEQUALINIUM CHLORIDE HYDRATE
  • Dequalinium chloride for performance test CRS
  • Dequalinium chloride CRS
  • Danical
  • Decabis
  • Dequalinium chloride USP/EP/BP
  • MitoBloCK-12
  • equaliniumchloride
  • 1,1'-(Decane-1,10-diyl)bis(4-amino-2-methylquinolin-1-ium) chloride
  • 522-51-0
  • C30H40CI2N4
  • C30H40Cl2N4
  • C30H40N42Cl
  • 52757
  • Heterocyclic Ammonium Salts
  • Ion Channels
  • Monovalent Ion Channels
  • Phase Transfer Catalysts